learn Cyproterone
a synthetic anti-androgen and weak progestogen that inhibits DHT binding to androgen receptor
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5 / 801 resultslearn Bicalutamide
a nonsteroidal anti-androgen, most commonly used orally for women
learn Clascoterone
a novel topical treatment that inhibits DHT on androgen receptors
learn Spironolactone
powerful topical and oral anti-androgen used mostly by women
learn Fluridil
a topical anti-androgen with less systemic involvement
Research
5 / 127 resultsresearch Effect of testosterone on chests and abdomens of transgender men
Testosterone increases hair growth and acne in transgender men.
research The Impact of Gender Affirming Hormone Therapy on Physical Performance
Gender-affirming hormone therapy improves physical performance in trans men to the level of cisgender men, while in trans women, it increases fat mass and decreases muscle mass, with no advantage in physical performance after 2 years.
research Body composition and physical fitness in transgender versus cisgender individuals: a systematic review with meta-analysis
This systematic review and meta-analysis, involving 52 studies with 6,485 participants, compared body composition and physical fitness between transgender and cisgender individuals. The findings reveal that transgender women have similar physical fitness levels to cisgender women, with comparable fat mass and strength, although they possess higher lean mass. Transgender men, however, have higher fat mass and lower lean mass and strength compared to cisgender men. Gender-affirming hormone therapy (GAHT) in transgender women leads to increased fat mass and decreased lean mass and strength over 1-3 years, while transgender men experience reduced fat mass and increased lean mass and strength. The study challenges the assumption of inherent athletic advantages for transgender women over cisgender women and suggests that policies regarding transgender athletes should be evidence-based and nuanced, rather than imposing blanket bans.
research SAT645 Cardiac Autonomic Modulation In Transgender Men Under Gender-affirming Hormone Therapy
Testosterone treatment may affect heart response to stress in transgender men.
research Social rejection in minority groups and its impact on current and future mental health: a study in transgender people
Social rejection can harm long-term mental health in transgender individuals.
Community Join
5 / 17 resultscommunity (MTF 35) 20 Months Feminizing HRT
A 35-year-old transgender woman experienced hair regrowth with feminizing HRT, adding dutasteride and bicalutamide, and plans a hair transplant for further improvement. Estrogen also improved skin appearance, and the user advises against cisgender men using feminizing HRT for hair regrowth.
community (MTF 35) Results of 18 Months of HRT
A transgender woman experienced significant hair regrowth after 18 months of hormone replacement therapy (HRT) with estrogen and bicalutamide. The discussion notes HRT's effectiveness for hair regrowth but warns against its use for cisgender men due to feminizing effects.
community Well… I Did It. Estrogen Saved My Hairline
OP transitioned and used Spironolactone, Estradiol Valerate, Minoxidil, and dermarolling, resulting in significant hair regrowth. They advise this method may not be suitable for cis men.
community I don’t understand this, is he equating taking Fin with being on HRT?
The conversation is about using finasteride and testosterone replacement therapy (TRT) for hair loss and their role in gender-affirming care. It debates whether these treatments are considered hormone replacement therapy (HRT) and their implications for both cisgender and transgender individuals.
community HRT is literal black magic. Fin 1 mg/day @ 4 years, min 2x/day @ 3 years, Estradiol 4mg/day @ 3.5 months, and Spironolactone 100mg/day @ 3.5 months (estra & spiro are medicines you should likely not take if you are a cis man)
User shared progress on hair regrowth using Fin 1 mg/day for 4 years, Min 2x/day for 3 years, Estradiol 4mg/day, and Spironolactone 100mg/day for 3.5 months. They noted significant hairline recovery and advised against HRT for cis men due to feminizing effects.