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GlossaryDrug Absorption

process by which a drug enters the bloodstream from administration

Drug absorption refers to the process by which a drug enters the bloodstream from its site of administration. This can occur through various routes such as oral, intravenous, or topical application. The efficiency and rate of absorption can be influenced by factors like the drug's formulation, the presence of food in the stomach, and the health of the gastrointestinal tract. Understanding drug absorption is crucial for determining the correct dosage and ensuring the drug's effectiveness.

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community Kintor Phase 2 Results released KX-826 (pyrilutamide)

in Research/Science 444 upvotes 3 years ago

Kintor Pharmaceutical's Phase 2 results with the drug Pyrilutamide, a potential alternative to 5-ARI drugs like Finasteride and Dutasteride but without the side effects. It could be used in combination with other topical treatments such as Minoxidil. The safety of the drug has been demonstrated in 6 months of use, however there are still questions about long term efficacy and systemic absorption.

community FIN/DUT with water, milk, coffee? What do you consume it with?

in Finasteride/Dutasteride 4 upvotes 5 years ago

People discuss taking finasteride and dutasteride with various drinks, noting that water is common, while some avoid grapefruit juice. Opinions vary on whether the choice of beverage affects drug absorption.

community Are we underestimating systemic absorption with homemade/generic Topical Fin? (HPCH vs. PG/Ethanol formulations)

in Research/Science 5 upvotes 3 months ago

Topical finasteride may have higher systemic absorption and lower efficacy when using a Propylene Glycol/Ethanol formulation compared to the hydroxypropyl chitosan (HPCH) formulation. The safety profile of topical finasteride relies heavily on the HPCH formulation, and using standard solutions might lead to different pharmacokinetics.

community PP405 Drug in Action: Picture From Official Company Website

in Technology 782 upvotes 1 year ago

PP405 shows promise for hair follicle reactivation with minimal side effects. Users recommend continuing Minoxidil and Finasteride until more results are confirmed.

community Effect of IBS on oral Fin/Min absorbtion. Should i switch to topical

in General 88 upvotes 3 months ago

The user experienced hair regrowth with oral minoxidil and finasteride but faced aggressive hair loss after developing IBS, questioning if the condition affects medication absorption. They are considering switching to topical treatments.

community Dutasteride is a Miracle Drug.

in Finasteride/Dutasteride 250 upvotes 9 months ago

Dutasteride is praised for improving skin and hair regrowth, with fewer side effects than finasteride. Users report mixed results on shedding and regrowth, with some experiencing enhanced libido and skin quality.

community Finasteride really is a miracle drug

in Finasteride/Dutasteride 181 upvotes 3 months ago

Finasteride and minoxidil help maintain hair and slightly improve hairlines but are less effective at regrowing hair in bald areas, often needing a hair transplant for full restoration. Many users report no side effects and wish they had started treatment earlier.

community Tretinoin and Minoxidil effectiveness

in Research/Science 8 upvotes 7 months ago

Tretinoin may enhance minoxidil absorption, potentially improving hair regrowth when combined with microneedling. Users discuss various treatments like minoxidil, finasteride, dutasteride, and microneedling, with mixed results and concerns about side effects and scarring.

community If I put tretinoin on my face and take oral min what happens

in Minoxidil 6 upvotes 1 year ago

Tretinoin boosts the absorption of topical minoxidil but does not affect oral minoxidil. Tretinoin is beneficial for skincare but does not enhance hair growth when used as a face cream.

community Efficacy and Systemic DHT Suppression of Topical Finasteride vs Dutasteride

in General 122 upvotes 1 year ago

Topical dutasteride may have limited absorption due to its higher molecular mass compared to finasteride, potentially affecting its efficacy in suppressing DHT locally. Microneedling might enhance dutasteride absorption, possibly offering stronger local DHT suppression with fewer systemic effects.

community Topical finasteride in liposomal formulation

in Finasteride 5 upvotes 6 years ago

Topical finasteride in a liposomal formulation reduces systemic absorption compared to ethanol solutions. The user is seeking sources for such products, noting that popular options like morr-f are not liposomal.

community Haircafe: Are dutasteride tablets less effective than dutasteride gel capsules?

in Finasteride/Dutasteride 38 upvotes 10 months ago

Dutasteride tablets are less effective than softgel capsules because they require a fat-based environment for proper absorption. Softgel capsules, like Avodart, are designed to maximize bioavailability, while powdered tablets may result in significantly lower DHT suppression.

community Does Apple cider vinegar interfere with oral minoxidil or finasteride?

in Product 3 upvotes 11 months ago

Apple cider vinegar, when taken as 1 tablespoon diluted with water daily, does not interfere with the absorption of oral minoxidil or finasteride.

community How long for RU58841 to absorb?

in Treatment 4 upvotes 1 year ago

The user is concerned about safely using RU58841 around cats and wonders if applying it 2 hours before a shower is as effective as leaving it overnight. The discussion focuses on the absorption time and effectiveness of RU58841.

community Fin/Dut and Metabolism Speeds…

in Finasteride/Dutasteride 8 upvotes 1 year ago

A user speculates that a fast metabolism might affect the effectiveness of dutasteride for hair loss. Another user argues that drug response is unrelated to metabolism speed.

community What’s your views on clascoterone 5% topical solution by cosmo

in Research/Science 23 upvotes 5 months ago

Clascoterone 5% topical solution shows promise for treating male-pattern hair loss by blocking DHT at the follicle without systemic absorption, potentially offering fewer side effects than oral treatments like finasteride. While results are promising, long-term safety and effectiveness need further study, and it may serve as a starting point for developing more effective treatments.

community Reasons why Topical worked but Oral Minoxidil didn’t?

in Minoxidil 16 upvotes 2 years ago

Some people find topical minoxidil effective for hair loss, but oral minoxidil doesn't work for them, possibly due to absorption issues. Others have had better results with oral minoxidil, suggesting individual responses vary.

community Binding affinity of pyrilutamide!

in Update 172 upvotes 4 years ago

Pyrilutamide, a nonsteroidal antiandrogen drug under development for the potential treatment of androgenic alopecia. The conversation discusses its binding affinity to the androgen receptor and the timeline for possible availability after trials are completed in the United States and China.

community discouraged about pyrilutamide

in Research/Science 11 upvotes 3 years ago

Discouragement regarding Pyrilutamide, a drug in development for hair loss, and the potential side effects of Finasteride. People discussed anecdotal experiences with Pyrilutamide as well as suggestions to wait out Phase 3 trials before making any conclusions.

community Mixing minoxidil with oil to prevent dry scalp

in Minoxidil 1 year ago

Mixing minoxidil with castor oil (and possibly rosemary oil) to prevent dry scalp. Concerns about whether this affects the potency or absorption of minoxidil.

community Clascoterone 12 months phase 3 result out

in Treatment 42 upvotes 1 month ago

Clascoterone is promising for hair loss, showing 24.5% improvement in satisfaction compared to placebo. Users consider it an alternative to finasteride, with concerns about absorption and side effects.

community Targeted Follicular Finasteride Delivery: A Low-Systemic Strategy

in Research/Science 14 upvotes 1 month ago

A peptide-based delivery system for finasteride shows promise in reducing systemic side effects while maintaining hair growth effectiveness. Combining this with other treatments like minoxidil and RU58841 could enhance results with lower systemic absorption.

community The expected timeline for PP405 - Next update at AAD Annual Meeting in March 2026 ?

in Treatment 30 upvotes 4 months ago

A new hair loss treatment, PP405, showed promising Phase 2a results with 31% of patients experiencing over 20% hair density increase without systemic absorption, avoiding hormonal side effects. The treatment is expected to be expensive, with Phase 3 trials starting mid-2026, and there is skepticism about the data's strength.

community Why is scalp DHT suppression lower than systemic?

in Finasteride/Dutasteride 11 upvotes 8 months ago

Dutasteride reduces DHT more effectively in hair follicles than finasteride, but some individuals still experience hair loss despite treatment. Combining oral and topical finasteride may improve results, and some users experiment with topical dutasteride despite uncertainties about its absorption.

community My DHT levels while being on DUT for a year

in Finasteride/Dutasteride 31 upvotes 10 months ago

The conversation discusses the ineffectiveness of tablet forms of dutasteride for hair loss due to poor absorption compared to soft gel capsules. It suggests switching to FDA-approved soft gel capsules for better results, as tablets may not adequately suppress DHT levels.

community What happened to topical dutasteride??

in Finasteride/Dutasteride 28 upvotes 1 year ago

Topical dutasteride is considered for hair loss, but concerns about systemic absorption and side effects like reduced libido are common. Users have mixed results, with some preferring oral finasteride or dutasteride despite side effects, while others find topical treatments beneficial but challenging.

community Can’t deal with minoxidil face bloating and I’m 6 months into treatment. Why’s the closest topical to replace it with?

in Minoxidil 7 upvotes 1 year ago

Minoxidil can cause face bloating, especially when combined with microneedling, as it may increase systemic absorption. Alternatives like Stemoxidine or Aminexil are considered, and some users find relief by adjusting application timing or switching brands.

community My Pyrilutamide Experience Update 2, Part 1

in Update 64 upvotes 3 years ago

The user's experience taking Pyrilutamide, a drug for hair loss treatment, and their use of it in combination with other treatments such as Minoxidil, Finasteride and RU58841. They have experienced positive results so far with no major side effects.

community Oral Minoxidil and Grapefruit Juice

in Research/Science 96 upvotes 2 years ago

The conversation is about the potential dangers of taking oral minoxidil and grapefruit juice together. Some users express concern about dangerous drug interactions, while others argue that grapefruit juice may inhibit the metabolism of finasteride. The conclusion is that grapefruit juice may make finasteride less effective, but it won't affect minoxidil.

community Phase II topical dut study - outperforms oral fin with a minor DHT reduction

in Research/Science 61 upvotes 3 months ago

Topical dutasteride 0.05% is more effective for hair growth than oral finasteride 1mg, with minimal DHT reduction. The formulation uses castor oil and MCTs for better absorption but is not widely available until 2028.