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GlossaryGorlin Syndrome

genetic disorder causing multiple skin cancers and jaw cysts

Gorlin Syndrome, also known as Nevoid Basal Cell Carcinoma Syndrome (NBCCS), is a genetic disorder characterized by the development of multiple basal cell carcinomas (a type of skin cancer), jaw cysts, and skeletal abnormalities. It is caused by mutations in the PTCH1 gene, which plays a role in cell growth and development. This syndrome can also lead to other health issues, such as developmental delays and an increased risk of other types of tumors.

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community Try to find picture of Justin Bieber without a hat in the last two years - challenge impossible

in Chat 164 upvotes 2 years ago

The conversation discusses Justin Bieber's apparent hair loss and the public's reaction to it, with some speculating he's had a hair transplant or is avoiding hair loss medications due to side effects or medical conditions. There's also mention of his past comments on Prince William's balding and the irony of his current situation.

community Male pattern baldness, and mental health

in Finasteride/Dutasteride 332 upvotes 2 years ago

A 48-year-old man has been using minoxidil for 15 years and considered finasteride but stopped due to potential side effects. He is concerned about his mental health and the impact of hair loss on self-image, and he encourages support among men experiencing hair loss.

community I accepted my hair loss and shaved it. Hair loss controls me no more

in Satire 330 upvotes 2 years ago

User accepted hair loss, shaved head, and feels free. Others joke about confusing photo angles.

community Pyrilutamide is literally my only hope

in Chat 91 upvotes 3 years ago

Considering treatments for hair loss, including Minoxidil, Finasteride, RU58841, Fluridil and Pyrilutamide. The user is weighing the risks of taking unapproved medication before it has been mass produced.

community 36m Is there any hope left? Fin hasn’t been working

in Satire 368 upvotes 2 years ago

The post discusses a user's struggle with hair loss and the ineffectiveness of finasteride. Suggestions from the conversation include trying oral minoxidil and considering a 3200 graft hair transplant.

community A one year treatment journey - a trip back to confidence land

in Progress Pictures 228 upvotes 4 months ago

A man used finasteride, minoxidil, and a derma pen for a year to improve hair growth with no significant side effects. He plans to continue the treatment and explore new options.

community Why so much hate for PP405 all of a sudden?

in Technology 48 upvotes 8 months ago

PP405 is a new hair loss treatment facing mixed reactions due to initial hype and insufficient data. Some are hopeful, but many doubt its effectiveness compared to minoxidil and finasteride.

community Selfmade. I hope you like it 😅

in Satire 629 upvotes 1 year ago

The conversation humorously discusses hair loss treatments, including minoxidil, finasteride, and dutasteride, with mixed results and experiences. Some users express concerns about side effects, while others share their regrowth stories or consider alternative solutions like hair transplants or shaving.

community The "I just want hair until im 30" cope.

in Chat 220 upvotes 1 year ago

Participants want to maintain hair until at least age 30, using treatments like finasteride, dutasteride, and minoxidil. Hair loss remains a concern, with some considering hair transplants.

community I think we all hop on estrogen. It's the only angle

in Satire 83 upvotes 1 year ago

The conversation humorously discusses hair loss treatments, including Minoxidil, finasteride, RU58841, and topical 17 alpha estradiol, with some users joking about transitioning to female to avoid baldness. The overall tone is satirical, emphasizing self-acceptance and the lengths people might consider for hair restoration.

community Minoxidil Eye Bags and Dark Circles

in Minoxidil 22 upvotes 2 years ago

Minoxidil users report dark circles and eye bags. Solutions include water pills, caffeine serum, retinol, and collagen peptides.

community 6 month results on topical min, oral fin, and microneedling

in Progress Pictures 707 upvotes 3 years ago

A user (Majestic-Head3874) who has had successful hair regrowth with the combination of topical minoxidil, oral finasteride and microneedling treatments. People are asking for details about these treatments and Majestic-Head3874 is sharing the regimen they used.

community (Updated) 9month hair gains on fin,min,niz

in Progress Pictures 711 upvotes 3 years ago

A user's nine-month journey of hair growth with treatments including finasteride, minoxidil, and nizoral; some participants thought the user had a hair transplant while others disagreed.

community Spiro for AGA in Europe

7 upvotes 6 years ago

Treatment options for female alopecia androgenetica, discussing the availability of spironolactone online in The Netherlands and other potential treatments like finasteride, minoxidil and RU58841.

community Female male-pattern AGA- seeking help

in Female 1 upvotes 2 years ago

A female with male-pattern hair loss (AGA) is seeking help after unsuccessful treatments with spironolactone and supplements, and is considering oral minoxidil and finasteride despite concerns about medication side effects. She has ruled out hormonal birth control and PRP/PRFM, and is looking into further medical advice due to abnormal lab results.

community Dont know what the hell is going on.

in Chat 6 upvotes 1 year ago

The user experienced rapid diffuse hair thinning for five years despite no signs of AGA or miniaturization. They tried finasteride and oral minoxidil without success and have checked thyroid, iron, and vitamin D levels.

community Proposed new pathogenesis model for androgenetic alopecia (AGA)

in Research/Science 6 upvotes 2 years ago

The conversation discusses a new model for understanding androgenetic alopecia (AGA), linking it to dietary and lifestyle factors similar to PCOS, and highlighting the role of DHT, vascular damage, and inflammation. Treatments mentioned include Minoxidil, finasteride, and RU58841.

community Anagenic is trying to compound Gt20029

in Treatment 58 upvotes 3 years ago

The conversation discusses concerns that Anagenic's version of GT20029 might not be as effective or safe as Kintor's, with comparisons to issues faced by pyrilutamide. The chemical structure of the drug has been published.

community May have been mis-diagnosed for 10 years, self-investigation into AGA + AA Incognita (Defused Shedding)

in Treatment 1 upvotes 1 year ago

A 27-year-old male with AGA and diffused thinning has been using oral Minoxidil, Finasteride, Vitamin D, B12, Iron, and Ketoconazole shampoo. Despite a hair transplant and improved blood levels, he continues to experience hair loss and suspects a possible misdiagnosis of Alopecia Areata Incognita.

community GT20029. Kintor Pharma’s Product

in Research/Science 12 upvotes 3 years ago

The conversation discusses GT20029, a compound by Kintor Pharma that degrades androgen receptors and is in trials, with potential as a hair loss cure. Another promising treatment mentioned is an antibody that blocks prolactin and has shown positive results in macaques.

community Spanish dermatologist suggests sulforaphane for AGA

in Research/Science 13 upvotes 2 years ago

A Spanish dermatologist suggests sulforaphane for androgenetic alopecia (AGA) due to its potential to remove DHT metabolites, though high dosages are needed. A topical formulation might be possible.

community CRISPR treatment for AGA on the horizon after approval for blood disorders

in Treatment 9 upvotes 2 years ago

CRISPR treatments for blood disorders have been approved, leading to discussions about its potential for treating hair loss (AGA). A study showed that editing a gene related to DHT sensitivity could lead to hair regrowth, suggesting CRISPR may eventually be used for AGA, but it's expected to be expensive and not soon available.

community Best Treatment In The Pipeline?

in Chat 15 upvotes 1 year ago

New treatments for AGA are emerging, including pyrilutumide, gt0029, scube3, kx-826, and pp405. Verteporfin is mentioned as a promising option.

community Where can I find the results of GT20029 phase 1 study in the US/China. The actual data

in Technology 6 upvotes 2 years ago

The conversation is about someone looking for specific side effects reported in clinical trials for GT20029, a hair loss treatment. No results or data were found on the clinical trials site.

community The Hormonal Profile of MPB/AGA

in Research/Science 9 upvotes 4 years ago

Men with early male pattern baldness (MPB) may have hormonal abnormalities similar to those in women with PCOS. Specific treatments mentioned include Minoxidil, Finasteride, and RU58841.

community What is preventing GT20029 from being the cure to androgenetic hair loss?

in Research/Science 10 upvotes 8 months ago

GT20029 is discussed as a potential treatment for androgenetic hair loss by targeting androgen receptors, unlike finasteride which reduces DHT broadly. Concerns include its effectiveness, genetic variations in androgen receptors, and availability, with some skepticism about its potential as a true alternative.

community GT20029 China Phase II Trial For AGA Reached Primary Endpoint

in Research/Science 134 upvotes 1 year ago

The GT20029 tincture, a topical androgen receptor degrader, showed significant hair growth and good safety in a China Phase II trial for male androgenetic alopecia (AGA), with the 1% dose twice weekly identified as optimal. The company plans to initiate Phase III trials in China and Phase II in the U.S., and the treatment also shows promise for acne.

community Chromosome 20’s balding effects and why fin likely isn’t working for some.

in Treatment 96 upvotes 7 months ago

Finasteride is effective for DHT/AR-driven hair loss but not for chromosome 20-driven cases, where treatments like minoxidil, prostaglandin analogs, and low-level laser therapy may be more beneficial. Genetic testing can help determine the underlying cause of hair loss to tailor treatment effectively.

community Having AGA as a girl makes me depressed

in Female 66 upvotes 2 months ago

A 20-year-old woman with androgenetic alopecia feels depressed about her hair loss, despite using topical minoxidil, spironolactone, and saw palmetto. Suggestions include trying oral minoxidil, higher doses of finasteride or dutasteride, and checking for vitamin deficiencies and heavy metal exposure.

community A concern regarding the upcoming androgen degrader drug GT20029

in Chat 12 upvotes 1 year ago

GT20029 is a topical treatment that degrades androgen receptors to prevent hair thinning and loss, potentially offering fewer side effects than systemic treatments like finasteride. Concerns include its impact on hair texture and potential systemic effects, with market availability speculated in 3 to 5 years.