community The MPB itch aka DHT itch is very real.
Hair loss itch is caused by DHT attacking follicles and stimulating nerves. Finasteride users who respond well don't experience this itch.
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30 / 1000+ resultscommunity Quote from Pelage (PP-405) Spokesperson...
Pelage is developing a topical hair follicle stem cell therapy, PP405, for non-scarring alopecias like androgenetic alopecia, with Phase III trials planned and a potential market launch by 2027. The treatment may not require continuous use after initial regrowth.
community Fibrosing alopecia in a pattern distribution
A user has been experiencing hair loss for 4 years, with treatments like minoxidil, finasteride, and various supplements proving ineffective. They were diagnosed with fibrosing alopecia in a pattern distribution, a condition that may require a combination of anti-inflammatory and hair growth treatments.
community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied
Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.
community Is Finasteride the only way to reduce scalp DHT?
A 24-year-old male experienced side effects like low libido and ED after starting finasteride post-hair transplant and is seeking alternatives to reduce scalp DHT. Suggestions include topical finasteride, Xpecia, DHT-reducing shampoos, and switching to dutasteride, with some users reporting fewer side effects with these alternatives.
community Anyone here have a lot of knowledge on hair follicle stem cells and progenitor cells for PP405?
Hair follicle stem cells remain in bald individuals, but progenitor cells do not, raising questions about hair regrowth claims by Pelage. PP405 is discussed as a potential treatment, with skepticism about its effectiveness compared to existing treatments like Minoxidil and Finasteride.
community "Hair Follicle Stem Cells are quiescent 99% of the time and permanently reside in the hair follicle"
Hair follicles are mostly dormant but can be reactivated with treatments like minoxidil, finasteride, and microneedling. A new drug, PP405, shows promise for hair regrowth but may not be available until 2027-2028.
community Hair follicle dermal papilla exosomes
The conversation discusses using hair follicle dermal papilla exosomes for hair loss treatment. It inquires about purchasing options for this treatment.
community Hair follicle cloning is already possible
Hair follicle cloning is claimed to be possible but not widely available due to potential safety issues, such as cancer risks. Current treatments like finasteride and dutasteride are not effective for everyone, and there is frustration over limited access to these medications.
community Hair follicle neogenesis
A user plans to experiment with creating new hair follicles using methods like derma rolling, applying lithium chloride, tannic acid, and various other substances including caffeine, ketoconazole, and raspberry ketones. They also consider using anti-inflammatories, immunosuppressants, and DHT inhibitors to potentially improve results.
community Do hair follicles dies or are dormant ?
Hair follicles can be dormant and potentially revived with treatments like finasteride and minoxidil, but irreversible loss occurs if certain structures are destroyed. Early intervention is more effective, and additional methods like microneedling may help.
community Do hair follicles ever really "die"? Or does all your front, mid, and crown hair just become vellus?
Hair follicles don't truly die but become severely miniaturized. Treatments like finasteride, dutasteride, and minoxidil can help restore hair by providing nutrients and reducing harmful effects on hair roots.
community How likely is it to reverse the hair count for each hair follicle?
Hair follicles can potentially produce more hair strands with treatments like Minoxidil and finasteride. Notable improvements in hair density are possible, but achieving multiple strands per follicle is uncertain.
community Hair follicles do die - my „hair“ is the proof of that statement.
The user discusses their experience with hair loss despite taking estrogen and cyproterone, and estimates needing around 3000 grafts for a feminine hairline. They are considering getting the procedure done in Turkey due to high European costs.
community Hair follicles comparison around mole in hairline - Effects of 1 month of treatment
After one month of treatment for hair loss, which included Dutasteride, oral Minoxidil, PRP with Dutasteride mesotherapy, microneedling, supplements, and a shampoo with finasteride and minoxidil, the user observed thicker hair and signs of new hair growth with no bad side effects. They plan to provide another update at the three-month mark.
community if hair follicle miniaturization happens slowly and gradually over a few hair cycles then wouldn't that mean that to regain maximum or top thickness from treatment you would at least need 5-10 years?
Hair regrowth from treatments like finasteride, dutasteride, and minoxidil can take several years, with most visible results appearing within 1-2 years and potential improvements continuing up to 10 years. Consistency and patience are crucial for achieving maximum hair thickness, as hair miniaturization and regrowth are gradual processes.
community "Unlimited" hair follicles for HT?
Hair loss discussion mentions Verterporfin for scar-free healing and hair follicle regeneration. Human study expected within 2 years.
community Has anyone here actually undergone experimental (grey market) hair cell therapy/follicle cloning?
Hair cell therapy and follicle cloning are still in experimental stages, with treatments like hair multiplication and regenerative hair therapy being marketed but not yet proven to create unlimited new follicles. There is skepticism about the effectiveness and legitimacy of these treatments, with some considering them scams.
community Realistic timeline for hair regeneration and follicle cloning?
Hair regeneration and follicle cloning are considered far from being feasible, with current treatments like finasteride, minoxidil, and hair transplants expected to remain dominant for the next 15-20 years. Some are hopeful that AI advancements might accelerate progress, but many remain skeptical about significant breakthroughs in the near future.
community If people technically have hair follicles all over their body with baby hairs, why is regrowing hair so difficult to do?
Hair loss treatments are difficult because hair follicles react differently to hormones and have varying growth cycles. Treatments mentioned include Minoxidil, finasteride, and RU58841.
community DHT to my hair follicles the day I turned 14
Hair loss, Minoxidil, finasteride, and RU58841 as potential treatments for it.
community Functional hair follicles grown from stem cells: Scientists have created natural-looking hair that grows through the skin using human induced pluripotent stem cells (iPSCs), a major scientific achievement that could revolutionize the hair growth industry.
Scientists have grown natural-looking hair from stem cells, potentially revolutionizing hair growth treatments. Concerns include cost, DHT resistance, and the need for future procedures.
community How far away are we from scalp/hair follicle cloning for an essentially unlimited transplant supply? And would prior transplants affect eligibility?
Hair/scalp cloning for unlimited transplants is likely a decade away, with prior transplants not significantly affecting future options. Advances in AI and research in wound-induced hair neogenesis are promising, but infrastructure and technology constraints remain challenges.
community Update: A New Therapeutic Channel - Hair Follicle Glucose Metabolism
Hair loss can be treated by correcting glucose metabolism in hair follicles and using equol as a safer DHT blocker. Production of these treatments is starting soon, and a Discord channel is available for more information.
community A New Therapeutic Channel to Come Soon: Hair Follicle Sugar Metabolism and Aldose Reductase
Hair loss therapies focusing on hair follicle sugar metabolism and aldose reductase. Potential treatments include magnesium supplements, avoiding high glycemic index foods, and antioxidants.
community Our Follicles, who art in hairven, hallowed be thy name; thy hairdom come; thy will be done; on earth as it is in hairven. Give us this day our daily regrowth. And forgive us our hat usage, as we forgive those who own hair against us. And lead us not into transplantation; but deliver us from balding
A 21-year-old with accelerated hair loss due to stress and weight loss is using minoxidil, finasteride, and microneedling to combat balding, despite experiencing a significant initial hair shed. They are committed to continuing treatment for at least three months and are considering switching to topical finasteride if necessary.
community Intermittent fasting triggers hair loss in study (suppresses hair follicle regeneration)
Intermittent fasting may suppress hair follicle regeneration, but opinions vary on its impact on hair loss. Some users report no negative effects or even hair improvement while using treatments like finasteride and minoxidil.
community PP405 Won't Work Long Term: Hair Follicle Damage Due to Abuse of the ISR System
PP405 may damage hair follicles if used long-term, suggesting cycling might be necessary. Combining it with finasteride could help maintain hair growth.
community Minoxidil experiment on single hair follicle
Minoxidil was applied to a single miniaturized hair follicle over four months, resulting in less miniaturization but not yet terminal growth. The user used a 5% minoxidil solution, specifically the Regaine brand, and observed changes using a handheld WiFi microscope.
community Rhamnose-Mediated Modulation of Hair Follicle Growth: Insights from Chemical Genomics
Rhamnose may promote hair growth and pigmentation, suggesting it as a potential hair loss treatment. The conversation discusses its potential alongside known treatments like Minoxidil, finasteride, and RU58841.