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GlossaryCXCL9

chemokine that attracts immune cells to inflammation sites

CXCL9, also known as Monokine Induced by Gamma Interferon (MIG), is a type of chemokine—a small signaling protein involved in the immune response. It plays a crucial role in attracting immune cells, particularly T-cells, to sites of inflammation or infection. This chemokine is often studied in the context of autoimmune diseases and inflammatory conditions, including alopecia areata, where it can contribute to the immune system's attack on hair follicles.

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research Polymorphisms in the promoter regions of the CXCL1 and CXCL2 genes contribute to increased risk of alopecia areata in the Korean population

8 citations , January 2015 in “Genetics and Molecular Research”

Certain gene variations increase the risk of alopecia areata in Koreans.

CXCL12 Neutralizing Antibody Promotes Hair Growth in Androgenic Alopecia and Alopecia Areata

research CXCL12 Neutralizing Antibody Promotes Hair Growth in Androgenic Alopecia and Alopecia Areata

January 2024 in “International Journal of Molecular Sciences”

Blocking the protein CXCL12 with a specific antibody can increase hair growth in common hair loss conditions.

CXCL12 Inhibits Hair Growth Through CXCR4

research CXCL12 inhibits hair growth through CXCR4

April 2022 in “Biomedicine & Pharmacotherapy”

CXCL12 protein slows down hair growth through its receptor CXCR4. Blocking this can potentially increase hair growth.

research The chemokine SDF-1/CXCL12 regulates the migration of melanocyte progenitors in mouse hair follicles

57 citations , April 2009 in “Differentiation”

SDF-1/CXCL12 and its receptor CXCR4 are crucial for melanocyte movement in mouse hair follicles.

research CXCL12+ dermal fibroblasts promote neutrophil recruitment and host defense by recognition of IL-17

32 citations , February 2024 in “The Journal of Experimental Medicine”

CXCL12+ fibroblasts help recruit neutrophils to fight skin infections.

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