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GlossaryDifferentially Expressed Genes

genes showing varied activity levels under different conditions

Differentially Expressed Genes (DEGs) are genes that show different levels of expression in different conditions, such as between healthy and diseased tissues. For example, in the context of alopecia, DEGs might be identified by comparing gene activity in hair follicles from individuals with alopecia to those without, helping researchers understand the molecular mechanisms underlying the condition.

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research 139 Identification of long noncoding RNAs in mouse hair follicle stem cells using computational methods

June 2020 in “The journal of investigative dermatology/Journal of investigative dermatology”

Scientists found new and known long non-coding RNAs in mouse hair follicle stem cells that may be important for stem cell function and could be targets for cancer treatment.

research H3K4me3 regulates the transcription of RSPO3 in dermal papilla cells to influence hair follicle morphogenesis and development

1 citations , August 2025 in “Epigenetics & Chromatin”

H3K4me3 helps control RSPO3 to influence hair growth and development.

Construction of Regulatory Network for Alopecia Areata Progression and Identification of Immune Monitoring Genes Based on Multiple Machine-Learning Algorithms

research Construction of regulatory network for alopecia areata progression and identification of immune monitoring genes based on multiple machine-learning algorithms

3 citations , May 2023 in “Precision clinical medicine”

Researchers found four genes that could help diagnose severe alopecia areata early.

Comparative Transcriptome Analysis of Fetal Skin Reveals Key Genes Related to Hair Follicle Morphogenesis in Cashmere Goats

research Comparative Transcriptome Analysis of Fetal Skin Reveals Key Genes Related to Hair Follicle Morphogenesis in Cashmere Goats

127 citations , March 2016 in “PLoS ONE”

Key genes and pathways crucial for hair follicle development in cashmere goats were identified, aiding fleece production improvement.

Morpho-Regulation in Diverse Chicken Feather Formation: Integrating Branching Modules and Sex Hormone-Dependent Morpho-Regulatory Modules

research Morpho‐regulation in diverse chicken feather formation: Integrating branching modules and sex hormone‐dependent morpho‐regulatory modules

13 citations , December 2018 in “Development, Growth & Differentiation”

Sex hormones, especially estradiol, can change chicken feather shapes and colors.

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