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GlossaryDifferentially Methylated Regions

areas of DNA with varying methylation patterns between samples

Differentially Methylated Regions (DMRs) are specific areas of DNA where the pattern of methylation—a chemical modification that can regulate gene expression—differs between two or more samples, such as between healthy and diseased tissues. These regions are important in studying conditions like alopecia, as changes in methylation can influence the activity of genes involved in hair growth and loss.

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research Badanie roli zmienności genetycznej i epigenetycznej w starzeniu się skóry twarzy i włosów głowy oraz genetyczna predykcja związanych z wiekiem cech wyglądu człowieka

March 2024 in “Jagiellonian University Repository (Jagiellonian University)”

Genetic and lifestyle factors influence skin and hair aging, and prediction models can help assess aging and cosmetic treatments.

research Independent Genomewide Screens Identify the Tumor Suppressor VTRNA2-1 as a Human Epiallele Responsive to Periconceptional Environment

153 citations , June 2015 in “GenomeBiology.com”

The environment around the time of conception can change the VTRNA2-1 gene in a way that lasts for years and may affect disease risk.

research Integrated Analysis of Methylome and Transcriptome Changes Reveals the Underlying Regulatory Signatures Driving Curly Wool Transformation in Chinese Zhongwei Goats

39 citations , January 2020 in “Frontiers in Genetics”

PDGFC gene may help select goats with desirable curly wool traits.

research Specialized Ribosomes in Human Dermal Fibroblast Senescence

September 2019 in “Journal of Investigative Dermatology”

Specialized ribosomes affect aging in human skin cells.

research Transcriptional Regulation of the Thymus Master Regulator Foxn1

6 citations , August 2022 in “Science immunology”

Foxn1 gene regulation is crucial for thymus development but not for hair growth.

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community How to increase Pyri concentration from 0.5% to 1% wihout using more volume ( 2ml x 2 per say for example )

in Chat 6 upvotes 1 year ago

OP wants to increase pyrilutamide concentration from 0.5% to 1% while already using finasteride. Users suggest waiting for a commercial 1% solution and caution against using grey market products.

community New Research- Creatine Increasing Scalp DHT Without Corresponding Serum DHT Increase

in Research/Science 124 upvotes 1 year ago

Creatine may increase scalp DHT without affecting serum DHT, potentially speeding up male pattern baldness (MPB) for those genetically prone. Treatments mentioned include Minoxidil, finasteride, and RU58841.

community Why is nobody studying the difference between donor and balding hair?

in Chat 89 upvotes 1 year ago

The conversation discusses why the difference between donor and balding hair isn't studied more to find a cure for hair loss. Treatments mentioned include Minoxidil, finasteride, and RU58841.

community I got my bloodwork done... What now?

in Update 6 upvotes 2 months ago

The user has been experiencing hair thinning despite taking finasteride and minoxidil for six months. Bloodwork suggests a vitamin D deficiency, and users recommend consulting a doctor and possibly supplementing vitamin D.

community Research Backed Dutasteride Simulator (Serum/scalp DHT included for all doses)

Fuzzasteride in Research 489 upvotes 1 year ago

A Dutasteride Simulator predicts serum dutasteride, serum DHT, and scalp DHT levels using models from research papers. It simulates various dosing schedules to determine steady-state effects and visualizes outcomes, including hair growth-related scalp DHT suppression.

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