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GlossaryTUNEL assay

detects DNA fragmentation in cells undergoing apoptosis

The TUNEL assay, or Terminal deoxynucleotidyl transferase dUTP nick end labeling, is a laboratory technique used to detect DNA fragmentation resulting from apoptotic signaling. It works by labeling the ends of broken DNA strands, allowing researchers to identify and quantify cells undergoing programmed cell death, which can be important in studies of diseases like cancer or conditions affecting hair follicles, such as alopecia.