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GlossaryFerroptosis

iron-dependent cell death caused by lipid peroxidation

Ferroptosis is a type of cell death that is distinct from other forms like apoptosis or necrosis. It is characterized by the accumulation of iron and the subsequent production of reactive oxygen species, leading to lipid peroxidation and cell membrane damage. This process is significant in various diseases, including cancer and neurodegeneration, and understanding it can help in developing targeted therapies.

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research Hyperandrogenism and insulin resistance modulate gravid uterine and placental ferroptosis in PCOS-like rats

104 citations , June 2020 in “Journal of Endocrinology”

Hyperandrogenism and insulin resistance in PCOS-like rats can lead to pregnancy complications due to increased cell death in the uterus and placenta.

research Suppression of uterine and placental ferroptosis by N-acetylcysteine in a rat model of polycystic ovary syndrome

53 citations , November 2021 in “Molecular Human Reproduction”

N-acetylcysteine may help treat uterine and placental issues in PCOS.

research miR-761-hepcidin/Gpx4 pathway contribute to unexplained liver dysfunction in polycystic ovary syndrome by regulating liver iron overload and ferroptosis

16 citations , January 2023 in “Gynecological Endocrinology”

Liver damage in PCOS is linked to iron overload and cell death due to the miR-761-hepcidin/GPX4 pathway.

research Effect of Sun exposure-induced ferroptosis mechanisms on pathology and potential biological processes of primary melanoma by microarray data analysis

12 citations , September 2022 in “Frontiers in Genetics”

Enhancing CD8+ T cell function to induce ferroptosis in tumor cells may help treat skin melanoma.

research CuATSM Enhances Wound Repair Without Scarring via Hippo/YAP Signalling Pathway to Reduce Ferroptosis and Macrophage Polarisation

3 citations , June 2025 in “Journal of Cellular and Molecular Medicine”

CuATSM speeds up wound healing and reduces scarring.

research S100A8 induces cyclophosphamide-induced alopecia via NCF2/NOX2-mediated ferroptosis

2 citations , February 2025 in “Free Radical Biology and Medicine”

Blocking S100A8 can reduce chemotherapy-induced hair loss.

Induction of Hyperandrogenism and Insulin Resistance Differentially Modulates Ferroptosis in Uterine and Placental Tissues of Pregnant Rats

research Induction of hyperandrogenism and insulin resistance differentially modulates ferroptosis in uterine and placental tissues of pregnant rats

2 citations , March 2020 in “bioRxiv (Cold Spring Harbor Laboratory)”

HAIR may cause fetal loss by triggering different cell death processes in the uterus and placenta.

research 4‐octyl itaconate alleviates cisplatin‐induced ferroptosis possibly via activating the NRF2/HO‐1 signalling pathway

1 citations , March 2024 in “Journal of Cellular and Molecular Medicine”

4-octyl itaconate may prevent hearing loss caused by the drug cisplatin by activating certain cell protection pathways.

research Targeting ferroptosis in photoaging: mechanisms and therapeutic potential of adipose-derived stem cell exosomes

March 2026 in “Plastic and Aesthetic Research”

Adipose-derived stem cell exosomes can help reduce skin aging from UV exposure.

Sinapic Acid and Glabridin Synergistically Mitigate Androgenetic Alopecia by Modulating Ferroptosis Through Stabilization of Beta-Catenin Against Ubiquitin-Dependent Degradation

research Sinapic acid and glabridin synergistically mitigate androgenetic alopecia by modulating ferroptosis through stabilization of β-catenin against ubiquitin-dependent degradation.

July 2025 in “PubMed”

Sinapic acid and glabridin together help hair growth in androgenetic alopecia.

Rapidly Gelling Sprayable Hydrogels Integrating Carbon Quantum Dots and Plant Extracellular Vesicles Enable Multifunctional Wound Care via Photothermal Management, Immunomodulation, and Ferroptosis

research Rapidly Gelling Sprayable Hydrogels Integrating Carbon Quantum Dots and Plant Extracellular Vesicles Enable Multifunctional Wound Care via Photothermal Management, Immunomodulation, and Ferroptosis

July 2025 in “Small”

A new sprayable hydrogel helps heal wounds faster and reduces inflammation.

research Dermal papilla cells-conditioned medium attenuates oxidative stress-induced senescence via ferroptosis inhibition

July 2025 in “Scientific Reports”

Dermal papilla cell-conditioned medium can help reduce skin aging caused by oxidative stress.

Ellagic Acid Inhibits Dihydrotestosterone-Induced Ferroptosis and Promotes Hair Regeneration by Activating the Wnt/Beta-Catenin Signaling Pathway

research Ellagic acid inhibits dihydrotestosterone-induced ferroptosis and promotes hair regeneration by activating the Wnt/β-catenin signaling pathway

April 2024 in “Journal of ethnopharmacology”

Ellagic acid may help regrow hair and prevent hair loss by activating a specific cell growth pathway.

Identification of Ferroptosis-Related Biomarkers in Alopecia Areata Through Machine Learning

research Identification of SLC40A1, LCN2, CREB5, and SLC7A11 as ferroptosis-related biomarkers in alopecia areata through machine learning

February 2024 in “Scientific reports”

Four genes are potential markers for hair loss condition alopecia areata, linked to a specific type of cell death.

Transcriptome Analysis of Frontal Fibrosing Alopecia Revealed Involvement of Immune Cells and Ferroptosis

research Transcriptome analysis of frontal fibrosis alopecia revealed involvement of immune cells and ferroptosis

February 2024 in “Skin research and technology”

The research suggests that immune cells and a specific type of cell death called ferroptosis are involved in Frontal fibrosis alopecia.

Schizochytrium Sp. Extracted Lipids Prevent Alopecia by Enhancing Antioxidation and Inhibiting Ferroptosis of Dermal Papilla Cells

research Schizochytrium sp. Extracted Lipids Prevent Alopecia by Enhancing Antioxidation and Inhibiting Ferroptosis of Dermal Papilla Cells

June 2023 in “Antioxidants”

Lipids from Schizochytrium sp. help prevent hair loss by protecting hair cells from damage and promoting hair growth.

Recent Progress in the Effect of Ferroptosis of Hepatic Stellate Cells on the Development of Liver Fibrosis

research Recent progress in the effect of ferroptosis of HSCs on the development of liver fibrosis

2 citations , September 2023 in “Frontiers in molecular biosciences”

Inducing ferroptosis in hepatic stellate cells is crucial for treating liver fibrosis.

research Induction of ferroptosis by natural products in non-small cell lung cancer: a comprehensive systematic review

6 citations , May 2024 in “Frontiers in Pharmacology”

Natural products may help treat Non-Small Cell Lung Cancer by causing cancer cell death through ferroptosis.

research NRF2 coordinates ferroptosis and disulfidptosis in dermal papilla cells via redox metabolic reprogramming in androgenetic alopecia

May 2026 in “Free Radical Biology and Medicine”

research Exploring the relationship between anastasis and mitochondrial ROS-mediated ferroptosis in metastatic chemoresistant cancers: a call for investigation

18 citations , July 2024 in “Frontiers in Immunology”

Targeting specific molecular pathways may improve treatments for chemoresistant cancers.

Docosahexaenoic Acid-Acylated Astaxanthin Esters Alleviate Cisplatin-Induced Acute Kidney Injury by Modulating the Ferroptosis-Related GPX4/xCT Signaling Pathway and Reducing Oxidative Stress

research Docosahexaenoic acid-acylated astaxanthin esters alleviate cisplatin- induced acute kidney injury by modulating the ferroptosis-related GPX4/xCT signaling pathway and reducing oxidative stress

January 2026 in “Food Science and Human Wellness”

Krill oil may help reduce prostate enlargement and growth.

Mechanism of Traditional Chinese Medicine in the Treatment of Ischemic Stroke by Intervening Ferroptosis Pathway Based on Molecular Target Prediction and Bioinformatics

research Mechanism of traditional Chinese medicine in the treatment of ischemic stroke by intervening ferroptosis pathway based on molecular target prediction and bioinformatics

January 2024 in “Research Square (Research Square)”

Traditional Chinese medicine may help treat ischemic stroke by targeting specific genes and pathways.

research Cell death in skin function, inflammation, and disease

12 citations , August 2022 in “Biochemical Journal”

Different types of cell death affect skin health and inflammation, and understanding them could improve treatments for skin diseases.

research Human hair follicle-derived mesenchymal stem cells improve ovarian function in cyclophosphamide-induced POF mice

7 citations , February 2025 in “Stem Cell Research & Therapy”

Human hair follicle stem cells improve ovarian function in mice with damaged ovaries.

research Dissecting hair breakage in alopecia areata: the central role of dysregulated cysteine homeostasis

3 citations , May 2024 in “Amino Acids”

Disrupted cysteine metabolism may cause hair breakage in Alopecia Areata, suggesting potential treatments like N-acetylcysteine.

research Discovery and Functional Analysis of Secondary Hair Follicle miRNAs during Annual Cashmere Growth

3 citations , January 2023 in “International journal of molecular sciences”

Certain miRNAs play a key role in the growth of cashmere by affecting hair follicle development and regeneration.

research Whole blood transcriptome profiling identifies candidate genes associated with alopecia in male giant pandas (Ailuropoda melanoleuca)

1 citations , April 2022 in “BMC Genomics”

Researchers found genes linked to hair loss in male giant pandas.

research Iron–Skin Axis: Exploring the Interplay between Iron Homeostasis and Skin Disorders

October 2025 in “Journal of Investigative Dermatology”

Iron balance is crucial for skin health, affecting conditions like psoriasis and hair loss.

Integrated Meta-Analysis of Scalp Transcriptomics and Serum Proteomics Defines Alopecia Areata Subtypes and Core Disease Pathways

research Integrated Meta-Analysis of Scalp Transcriptomics and Serum Proteomics Defines Alopecia Areata Subtypes and Core Disease Pathways

October 2025 in “International Journal of Molecular Sciences”

Early intervention in patch-type alopecia may prevent progression to more severe forms by targeting immune pathways and preserving keratin.

research The Retinoic-Acid-Related Orphan Receptor Alpha May Be Highly Involved in the Regulation of Seasonal Hair Molting

February 2025 in “International Journal of Molecular Sciences”

RORA plays a key role in controlling seasonal hair molting by affecting hair follicle cell activity.