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GlossaryHair Follicle Involution

process where hair follicles shrink and stop growing hair

Hair follicle involution refers to the process where hair follicles shrink and enter a resting phase, leading to hair shedding. This is a natural part of the hair growth cycle, known as the catagen phase, where the follicle stops producing hair and prepares for a period of dormancy before eventually regenerating and starting a new growth cycle.

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Research

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research Thrombospondin-1 Plays a Critical Role in the Induction of Hair Follicle Involution and Vascular Regression During the Catagen Phase

52 citations , January 2003 in “Journal of Investigative Dermatology”

Thrombospondin-1 is crucial for hair follicle regression and reduced blood vessel growth during the catagen phase.

research p75 Neurotrophin Receptor Antagonist Retards Apoptosis-driven Hair Follicle Involution (Catagen)

24 citations , January 2003 in “Journal of Investigative Dermatology”

Blocking a specific receptor slows down hair loss in mice.

research Changes in Different Melanocyte Populations During Hair Follicle Involution (Catagen)

40 citations , November 2005 in “The journal of investigative dermatology/Journal of investigative dermatology”

Different melanocyte types in hair follicles either survive or die during the catagen phase.

research Involvement of the Edar Signaling in the Control of Hair Follicle Involution (Catagen)

43 citations , December 2006 in “The American journal of pathology”

Edar signaling is crucial for controlling hair growth and regression.

research BMP signaling in the control of skin development and hair follicle growth

165 citations , December 2004 in “Differentiation”

BMP signaling is crucial for skin and hair growth.

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Community Join

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community Is this broscience? From More Plates, More Dates

in Research/Science 21 upvotes 2 years ago

The conversation discusses whether finasteride's reduction of DHT and increase in scalp testosterone contribute to hair follicle miniaturization. Some participants argue testosterone does not cause miniaturization, while others suggest that even with reduced DHT, other androgens like testosterone may still contribute to hair loss.

community Taking Charge of Your Hair: The "Big 3 Stack" Explained for 2023

in Research/Science 129 upvotes 2 years ago

The "Big 3 Stack" for hair loss treatment, which includes Minoxidil for hair density improvement, Ketoconazole shampoo for enhancing hair volume and thickness, and Finasteride for blocking hair loss causing hormones. Microneedling can boost Minoxidil's effects.

community Perifollicular Fibrosis and its role in androgenetic alopecia. Is Aminexil/Kopexil a must for anyone with AGA?

in Research/Science 4 upvotes 4 years ago

Aminexil/Kopexil may help reduce hair loss by addressing perifollicular fibrosis in androgenetic alopecia, but it lacks the extensive clinical backing of finasteride and minoxidil. Some users find it effective, but availability and cost are issues, especially in the US where it's not FDA-approved.

community Anyone here have a lot of knowledge on hair follicle stem cells and progenitor cells for PP405?

in Chat 4 upvotes 6 months ago

Hair follicle stem cells remain in bald individuals, but progenitor cells do not, raising questions about hair regrowth claims by Pelage. PP405 is discussed as a potential treatment, with skepticism about its effectiveness compared to existing treatments like Minoxidil and Finasteride.

community "Hair Follicle Stem Cells are quiescent 99% of the time and permanently reside in the hair follicle"

in Research/Science 1391 upvotes 10 months ago

Hair follicles are mostly dormant but can be reactivated with treatments like minoxidil, finasteride, and microneedling. A new drug, PP405, shows promise for hair regrowth but may not be available until 2027-2028.

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Clinics

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Learn

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learn Latanoprost

glaucoma medication with hair follicle stimulant effects

learn Verteporfin

chemical that might completely regrow follicles from hair transplant extractions

learn Hair Multiplication

extract, clone, and reinsert your own hair cells

learn Exosomes

Microscopic delivery system that sends growth-promoting signals to hair follicles

learn Baricitinib

JAK inhibitor that reduces inflammation and immune attacks on hair follicles, leading to potential hair regrowth, especially in alopecia areata cases

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Experts

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