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GlossaryHair Follicle Involution

process where hair follicles shrink and stop growing hair

Hair follicle involution refers to the process where hair follicles shrink and enter a resting phase, leading to hair shedding. This is a natural part of the hair growth cycle, known as the catagen phase, where the follicle stops producing hair and prepares for a period of dormancy before eventually regenerating and starting a new growth cycle.

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research Thrombospondin-1 Plays a Critical Role in the Induction of Hair Follicle Involution and Vascular Regression During the Catagen Phase

52 citations , January 2003 in “Journal of Investigative Dermatology”

Thrombospondin-1 is crucial for hair follicle regression and reduced blood vessel growth during the catagen phase.

research p75 Neurotrophin Receptor Antagonist Retards Apoptosis-driven Hair Follicle Involution (Catagen)

24 citations , January 2003 in “Journal of Investigative Dermatology”

Blocking a specific receptor slows down hair loss in mice.

research Changes in Different Melanocyte Populations During Hair Follicle Involution (Catagen)

40 citations , November 2005 in “The journal of investigative dermatology/Journal of investigative dermatology”

Different melanocyte types in hair follicles either survive or die during the catagen phase.

research Involvement of the Edar Signaling in the Control of Hair Follicle Involution (Catagen)

43 citations , December 2006 in “The American journal of pathology”

Edar signaling is crucial for controlling hair growth and regression.

research BMP signaling in the control of skin development and hair follicle growth

165 citations , December 2004 in “Differentiation”

BMP signaling is crucial for skin and hair growth.

research Intercellular Adhesion Molecule-1 and Hair Follicle Regression

29 citations , April 2000 in “Journal of histochemistry and cytochemistry/The journal of histochemistry and cytochemistry”

ICAM-1 helps regulate hair growth cycles and skin remodeling.

Human Hair Follicles Can Taste: Stimulation of the Bitter Taste Receptor TAS2R4 Inhibits Hair Growth Ex Vivo by Up-Regulating TGF-β2

research 571 Human Hair Follicles can “Taste”: Stimulation of the Bitter Taste Receptor TAS2R4 Inhibits Hair Growth Ex Vivo by Up-Regulating TGF-β2

November 2022 in “Journal of Investigative Dermatology”

Activating a bitter taste receptor in hair follicles can stop hair growth by increasing a specific growth factor.

research The role of integrin alphavbeta6 in impaired wound healing and hair follicle regeneration

January 2010

Integrin alphavbeta6 is important for wound healing and hair growth, and blocking it may improve these processes.

research The possibilities of correction of premature greying of hair and involutive hair changes

July 2024 in “Medical alphabet”

Premature graying and hair changes can be treated with certain peptides and possibly targeting the endocannabinoid system.

research Considerations on Hair Research and Hair Growth

7 citations , January 1981 in “Springer eBooks”

The document concludes that hair biology is complex and there are still unanswered questions about hair loss and follicle changes.

research DNA determination of human hair bulbs in normal and androgenetic alopecia

1 citations , August 1994 in “Journal of Cutaneous Pathology”

Hair loss happens due to faster cell growth and fewer cells in affected follicles.

research Regulation of the human hair cycle

2 citations , May 2001 in “Current problems in dermatology”

The conclusion is that effectively treating hair disorders is difficult due to the complex factors affecting hair growth and more research is needed to improve treatments.

research Morphological analysis of in vitro human hair growth

13 citations , January 1993 in “Archives of dermatological research”

Human hair follicles can grow and stay healthy for up to 8 days in a lab setting.

research Immunohistochemical analysis of tissue remodelling during the anagen-catagen transition of the human hair follicle

47 citations , July 1997 in “British Journal of Dermatology”

The inner root sheath is crucial for hair follicle stability during the transition from growth to involution.

research Amyloid-Associated Alopecia: A Reappraisal Including Its Pathophysiology

6 citations , March 2019 in “The American Journal of Dermatopathology”

Amyloid deposits linked to a type of protein may cause a unique pattern of hair loss by disrupting hair growth cycles.

research Study regarding the microscopic aspects of pilo-sebaceous units after antiandrogen treatment in hirsute women.

January 2015 in “PubMed”

Antiandrogen treatment helps reduce hair follicles and sebaceous glands in hirsute women.

research Mechanism of Action of Isotretinoin

3 citations , October 2019 in “CRC Press eBooks”

Isotretinoin effectively treats severe acne but can cause significant side effects like dry skin and hair loss.

research Etiology and diagnosis of androgenetic alopecia

9 citations , October 1988 in “Clinics in Dermatology”

Hair loss is caused by genetics and hormones, diagnosed through examination and biopsy, and treated with medications or surgery.

research Alopecia: histologic changes.

3 citations , January 1989 in “PubMed”

The review found that specific changes in scalp tissue can help diagnose different types of hair loss.

research Zwischen Tradition und Innovation Historische Plätze in der Bundesrepublik Deutschland nach 1945

1 citations , January 2004

Understanding hair growth phases and signals can help treat hair disorders.

research Immunohistochemical analysis of tissue remodelling during the anagen—catagen transition of the human hair follicle

23 citations , July 1997 in “British Journal of Dermatology”

The inner root sheath is vital for hair follicle stability during growth changes.

research [Molecular approach of hair biology].

6 citations , January 1994 in “PubMed”

The molecular mechanisms controlling hair growth phases are not fully understood yet.

research Hair Cycle Control by Vanilloid Receptor-1 (TRPV1): Evidence from TRPV1 Knockout Mice

49 citations , April 2006 in “Journal of Investigative Dermatology”

TRPV1 helps regulate hair growth cycles.

research Lifestyle and Adiponectin Level: Four-Year Follow-up of Controlled Trials

5 citations , July 2010 in “Archives of Internal Medicine”

Prostaglandins may protect hair follicles during chemotherapy.

research The causes of age-related alopecia from the point of view of modern morphology

January 2025 in “JOURNAL of SIBERIAN MEDICAL SCIENCES”

Age-related hair loss is linked to changes in blood vessels, stem cells, and aging cells, and understanding these can help keep hair healthy as we age.

research Alopecie acquisite

August 2021 in “EMC - AKOS - Trattato di Medicina”

Acquired alopecia is hair loss that can be reversible or irreversible, depending on whether the hair follicle is destroyed.

research Adipocyte-myofibroblast transition as a possible pathophysiological step in androgenetic alopecia

18 citations , May 2017 in “Experimental Dermatology”

AMT may cause hair loss and changing dWAT activity could help treat it.

research Alopecia na mulher

January 2013 in “Revista brasileira de medicina”

The study concluded that hair loss treatments should be tailored to the specific type of alopecia and individual patient needs.

research Molecular Control of Epithelial–Mesenchymal Interactions During Hair Follicle Cycling

277 citations , June 2003 in “The journal of investigative dermatology. Symposium proceedings/The Journal of investigative dermatology symposium proceedings”

Epithelial-mesenchymal interactions control hair growth cycles through specific molecular signals.

research Keratin 17 modulates hair follicle cycling in a TNFα-dependent fashion

169 citations , May 2006 in “Genes & Development”

Keratin 17 is crucial for normal hair growth by regulating hair cycle transitions with TNFα.