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GlossaryInfundibulum

funnel-shaped upper part of a hair follicle

The infundibulum is the funnel-shaped upper part of a hair follicle, located just below the opening of the follicle at the skin's surface. It plays a crucial role in guiding the hair shaft as it grows and emerges from the skin, and it also serves as a pathway for sebum and other substances to reach the skin's surface.

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Research

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research Upregulation of interfollicular epidermal and hair infundibulum β-catenin expression in Gsdma3 mutant mice

11 citations , June 2012 in “Acta histochemica”

Mice with a Gsdma3 gene mutation have thicker skin and longer hair follicle openings due to increased β-catenin levels.

research THE PRESENCE OF ANTIOXIDANTS IN THE HAIR INFUNDIBULUM IMPLICATIONS IN HAIR DISEASES SUCH AS ALOPECIA

June 2022 in “International Journal of Research -GRANTHAALAYAH”

Antioxidants like catalase are important for preventing hair loss conditions like alopecia.

research Pilomatricoma can differentiate not only towards hair matrix and hair cortex, but also follicular infundibulum, outer root sheath and hair bulge

18 citations , March 2009 in “Experimental Dermatology”

Pilomatricoma can develop into various hair-related structures.

research Deciphering the functions of the hair follicle infundibulum in skin physiology and disease

38 citations , September 2014 in “Cell and Tissue Research”

The hair follicle infundibulum plays a key role in skin health and disease, and understanding it better could lead to new skin disease treatments.

research Early stage alopecia areata is associated with inflammation in the upper dermis and damage to the hair follicle infundibulum

22 citations , June 2013 in “Australasian Journal of Dermatology”

Early stage bald spots are linked to skin inflammation and damage to the upper part of the hair follicle.

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Community Join

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community I think I’ve finally found the reason for my hair loss

in Chat 98 upvotes 1 year ago

The user experienced hair loss since 2019 and tried finasteride, dutasteride, RU58841, and ketoconazole shampoo without success. A scalp biopsy showed scarring and inflammation from folliculitis, indicating chronic inflammation was affecting treatment effectiveness.

community The MPB itch aka DHT itch is very real.

in Chat 9 upvotes 3 years ago

Hair loss itch is caused by DHT attacking follicles and stimulating nerves. Finasteride users who respond well don't experience this itch.

community Fibrosing alopecia in a pattern distribution

in Research/Science 14 upvotes 2 years ago

A user has been experiencing hair loss for 4 years, with treatments like minoxidil, finasteride, and various supplements proving ineffective. They were diagnosed with fibrosing alopecia in a pattern distribution, a condition that may require a combination of anti-inflammatory and hair growth treatments.

community Quote from Pelage (PP-405) Spokesperson...

in Research/Science 122 upvotes 9 months ago

Pelage is developing a topical hair follicle stem cell therapy, PP405, for non-scarring alopecias like androgenetic alopecia, with Phase III trials planned and a potential market launch by 2027. The treatment may not require continuous use after initial regrowth.

community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

in Research 830 upvotes 1 year ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

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