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GlossaryHair Shaft Defects

refer to structural abnormalities in hair strands

Hair Shaft Defects refer to abnormalities in the structure of the hair strand that can lead to issues like brittleness, breakage, and an overall unhealthy appearance. These defects can be caused by genetic conditions, environmental damage, or improper hair care practices, and they often require specific treatments or changes in hair care routines to manage effectively.

Related Terms

Research

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research MULTIPLE DEFECTS OF THE HAIR SHAFT IN NETHERTON'S DISEASE.

58 citations , November 1969 in “British Journal of Dermatology”

Netherton's disease causes multiple hair defects.

research Transgenic Kallikrein 14 Mice Display Major Hair Shaft Defects Associated with Desmoglein 3 and 4 Degradation, Abnormal Epidermal Differentiation, and IL-36 Signature

15 citations , June 2020 in “The journal of investigative dermatology/Journal of investigative dermatology”

Mice with extra human KLK14 had hair and skin problems, including weaker cell bonds and inflammation, linked to Netherton syndrome.

research Correction of Hair Shaft Defects through Allele-Specific Silencing of Mutant Krt75

6 citations , September 2015 in “Journal of Investigative Dermatology”

Using special RNA to target a mutant gene fixed hair problems in mice.

research Hair Shaft Defect in a Teenage Girl: Trichoscopy Saves the Day!

December 2020 in “Dermatology practical & conceptual”

Trichoscopy helped diagnose a teenage girl's hair loss as monilethrix.

research Acquired pili torti--a structural hair shaft defect in anorexia nervosa.

15 citations , March 1996 in “PubMed”

Anorexia nervosa may cause a hair defect called pili torti due to malnutrition and high vitamin A levels.

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Community Join

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community [20M] Hair Regrowth with Minoxidil ONLY- Need Opinions

in Minoxidil 244 upvotes 1 year ago

A 20-year-old is using minoxidil for hair regrowth and considering finasteride despite concerns about side effects. Many suggest adding finasteride to maintain gains, with recommendations to start with a low dose or use a topical form to minimize side effects.

community Hair loss research is a money grab

in Chat 227 upvotes 9 months ago

Hair loss is linked to DHT, with treatments like finasteride and minoxidil being common but not definitive. Economic interests influence research, and there is potential for new treatments like PP405 and RU58841.

community Why do we have head hair in first place if we evolved to start losing it in some cases as soon as puberty hits

in Chat 138 upvotes 10 months ago

Hair loss is influenced by genetics and sensitivity to hormones like DHT. Treatments like Minoxidil and finasteride are commonly used, and baldness persists as it doesn't affect reproductive success.

community 6 months into Dutasteride and my hair is way worse than before

in Finasteride/Dutasteride 70 upvotes 2 years ago

After six months on Dutasteride, the user's hair is worse than before, despite previously trying finasteride and RU/Fluridil without success. Some suggest continuing Dutasteride and adding progress photos, while others share their positive experiences or advise sticking to one treatment for at least a year.

community [13-Year Hair Loss Journey – Reached Norwood 7, Trying Again in 2025 (Male, 32, Vietnam)]

in Progress Pictures 246 upvotes 9 months ago

A 32-year-old man from Vietnam, at Norwood 7 hair loss, is using Minoxidil, Finasteride, rosemary oil, NMN, and CoQ10 to regrow hair. Despite minor improvements, alternatives like hair systems or accepting baldness are suggested due to advanced hair loss.

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