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research Isotretinoin-Based Treatment in Patients with Acne: Main Physiological and Psychological Effects

December 2025 in “International Journal of Research in Dermatology”

Isotretinoin is highly effective for treating moderate to severe acne, offering potential long-term remission, but its use is limited by significant adverse effects. Physiological side effects include teratogenic risk, cheilitis, xerosis, ocular changes, dyslipidemia, musculoskeletal pain, and hepatic function alterations. The psychological impact is debated, with some studies indicating increased depression and suicidality, while others report improved psychosocial well-being due to acne resolution. These mixed findings may be influenced by the psychological burden of acne itself. Isotretinoin remains essential in acne management, necessitating careful monitoring and patient education. Future research should focus on distinguishing the psychiatric effects of the drug from those related to severe acne and improving strategies to reduce physiological toxicity.

research Physiologic Skin Changes in Pregnancy

141 citations , January 1984 in “Journal of The American Academy of Dermatology”

Pregnancy can cause skin darkening, varicose veins, more sweating, hair growth, hair loss after birth, nail changes, and gum inflammation.

research Idiopathic Hirsutism: Androgen Role and Treatment Options

47 citations , August 2000 in “Endocrine Reviews”

The document concludes that more research is needed to understand excessive hair growth in women with normal hormone levels and regular ovulation.

research Steroids And Steroid-Like Compounds

55 citations , July 1999 in “Clinics in Sports Medicine”

Athletes use steroids to enhance performance despite health risks and legal issues, and education on their dangers is needed.

research Endocrine Care of Transpeople Part I: A Review of Cross-Sex Hormonal Treatments, Outcomes, and Adverse Effects in Transmen

45 citations , March 2015 in “Clinical Endocrinology”

Testosterone therapy is generally safe for transmen, improves sexual function, and has manageable health risks with proper monitoring.

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community 1 year of 1mg finasteride a day

in Progress Pictures 305 upvotes 5 months ago

The user has been taking 1mg of finasteride daily for a year, maintaining hair density without regrowth. They are considering oral minoxidil for regrowth, avoiding topical minoxidil due to its toxicity to cats, despite concerns about heart side effects.

community A warning to those using or thinking about using Dutasteride – Follow-up

in Finasteride/Dutasteride 18 upvotes 5 years ago

The post and conversation are about the long-term side effects of using Dutasteride and Finasteride for hair loss, including issues like raised liver enzymes, high cholesterol, and loss of libido. The user advises regular blood work and careful monitoring for those using these treatments.

community Finasteride/dut. causes NAFLD,IR,diabetes,kidney dysfunction is it correct.

in Finasteride/Dutasteride 139 upvotes 2 years ago

Hair loss discussion mentions treatments like Finasteride, Dutasteride, and Minoxidil. Users share experiences, side effects, and advice on using these treatments.

community How is dht not beneficial to you?

in Finasteride/Dutasteride 111 upvotes 1 month ago

DHT is important for sexual function and mood, but finasteride and dutasteride can reduce DHT, causing side effects like reduced libido and erectile dysfunction. These treatments are effective for hair loss, but their impact on DHT leads to debate.

community Study: There is 70x Higher Unconjugated DHT in Feces Compared To Blood Levels in Young Adults - Gut Microbiota Manages DHT Recycling and Metabolism

in Research/Science 194 upvotes 9 months ago

Gut microbiota significantly influences androgen metabolism, impacting hair loss treatments like finasteride. Probiotics, dietary changes, and fecal microbiota transplants may help manage DHT levels and improve hair health.

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