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GlossaryHistone Deacetylases

enzymes that remove acetyl groups from histone proteins

Histone Deacetylases (HDACs) are enzymes that remove acetyl groups from histone proteins, leading to a more compact and less accessible form of DNA. This process can suppress gene expression by making it harder for transcription factors to access the DNA. HDACs play a crucial role in regulating gene activity and are involved in various biological processes, including cell cycle progression and differentiation.

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Disrupted Ectodermal Organ Morphogenesis in Mice with a Conditional Histone Deacetylase 1, 2 Deletion in the Epidermis

research Disrupted Ectodermal Organ Morphogenesis in Mice with a Conditional Histone Deacetylase 1, 2 Deletion in the Epidermis

32 citations , June 2013 in “Journal of Investigative Dermatology”

Mice without certain skin proteins had abnormal skin and hair development.

research Sodium Valproate Improves Skin Flap Survival via Gamma-Aminobutyric Acid and Histone Deacetylase Inhibitory System

8 citations , October 2019 in “The Journal of surgical research/Journal of surgical research”

Sodium valproate helps skin healing by affecting GABA and histone deacetylase.

research Histone deacetylase 1 in patients with alopecia areata and acne vulgaris: An epigenetic alteration

4 citations , January 2022 in “Australasian Journal of Dermatology”

Higher HDAC1 levels in alopecia areata suggest HDAC inhibitors might help treat it and acne.

research Histone deacetylase inhibitors promote neurosteroid‐mediated cell differentiation and enhance serotonin‐stimulated brain‐derived neurotrophic factor gene expression in rat C6 glioma cells

35 citations , April 2009 in “Journal of Neuroscience Research”

HDAC inhibitors help brain cells grow and improve brain function.

research Nerve-mediated expression of histone deacetylases regulates limb regeneration in axolotls

12 citations , February 2019 in “Developmental Biology”

Nerve signals are essential for axolotl limb regeneration by regulating HDAC1.

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learn Valproic acid

an anticonvulsant repurposed for hair loss via histone inhibition

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