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GlossaryHypophosphatemia

condition with abnormally low blood phosphate levels

Hypophosphatemia is a condition characterized by abnormally low levels of phosphate in the blood. Phosphate is essential for energy production, bone health, and cell function, so a deficiency can lead to muscle weakness, bone pain, and impaired cellular processes. This condition can result from poor dietary intake, certain medical conditions, or the use of specific medications.

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research P-18 THREE BODY PROBLEM PATIENT: EHLER DANLOS SYNDROME COMBINED WITH HYPOPHOSPHATASIA AND FATTY ACID OXIDATION DEFECT

January 2025 in “JCEM Case Reports”

Enzyme replacement therapy may help alleviate symptoms in complex cases like this.

research Persistent hyperparathyroidism in vitamin D-dependent rickets type 2A does not prevent normalization of hypophosphatemia or healing of the rickets

May 2025 in “Hormone Research in Paediatrics”

Persistent hyperparathyroidism doesn't stop rickets healing or phosphate level normalization in VDDR2A.

research Mechanism of Vitamin D Receptor Action

111 citations , April 2006 in “Annals of the New York Academy of Sciences”

Vitamin D receptor is essential for healthy bones and skin.

research 1,25-dihydroxyvitamin D resistance, rickets, and alopecia

110 citations , November 1984 in “The American Journal of Medicine”

A genetic defect in vitamin D receptors causes severe rickets and hair loss in children, but some heal as they age.

research Vitamin D resistance

45 citations , December 2006 in “Baillière's best practice and research in clinical endocrinology and metabolism/Baillière's best practice & research. Clinical endocrinology & metabolism”

Vitamin D and its receptor are essential for hair growth, cell regulation, immune function, and heart health.

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