research In Vivo Imaging of Mammary Epithelial Cell Dynamics in Response to Lineage-Biased Wnt/β-Catenin Activation
Activating β-catenin in mammary cells leads to changes that cause early-stage abnormal growths similar to skin structures.
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5 / 1000+ results research Induced Mammary Epithelial Cell-Derived Extracellular Vesicles Promote the Repair of Skin Trauma
This study demonstrates that extracellular vesicles from chemically induced mammary epithelial cells (CiMECs-EVs) can effectively promote skin wound repair. By combining CiMECs-EVs with a chitosan hydrogel to create a composite repair system (CMECG), researchers observed significant improvements in wound healing in a rat model. The CMECG system enhanced wound closure efficiency to 90% compared to 70% in the control group by day 14. The system facilitated fibroblast and mammary epithelial cell proliferation and migration, restored skin layer continuity, and promoted collagen synthesis and remodeling. The healing effects are linked to miRNAs within CiMECs-EVs, which regulate cell proliferation, migration, angiogenesis, and inflammation, involving pathways like MAPK, PI3K-Akt, and TGF-β. This novel EV-chitosan hydrogel system offers a promising therapeutic strategy for clinical skin wound repair.
research Stabilization of Epithelial Beta-Catenin Compromises Mammary Cell Fate Acquisition and Branching Morphogenesis
Keeping β-catenin levels high in mammary cells disrupts their development and branching.
research Mammary Cells with Active Wnt Signaling Resist ErbB2-Induced Tumorigenesis
Cells with active Wnt signaling are less likely to turn into cancer when exposed to a cancer-causing gene.
research Distinct Stem Cells Contribute to Mammary Gland Development and Maintenance
Different types of long-lasting stem cells are responsible for the growth and upkeep of the mammary gland.
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5 / 13 resultscommunity My strong recommendation for those shedding hair
A user with aggressive male pattern baldness found that topical melatonin significantly reduced their hair shedding to 1 or 2 hairs per day and noticed some thickening of side hair. They tried many treatments like finasteride and minoxidil with little success, but topical melatonin showed immediate results in reducing hair loss.
community Finasteride caused HPS for me. A cautionary tale
User warns about finasteride causing Huge Penis Syndrome (HPS) with 2cm/year growth. Others joke about the side effect and share their experiences.
community My Progress - 56 y/o with NW7 hairloss
A 57-year-old man with severe hair loss since age 14 tried various hair loss treatments over two years, including finasteride, dutasteride, minoxidil, and supplements, with some minor regrowth. He also experimented with topical treatments and microneedling, but results were not cosmetically significant.
community Does RU58841 potentially cause cancer?
RU58841 may pose cancer risks due to its antiandrogen properties and lack of long-term safety data. Using it is considered a high-risk experiment with unknown potential for harm.
community 22M Seeking Advice: Gyno, Insulin Resistance and Hair Loss Solutions
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serrodna
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6 months ago A 22-year-old is experiencing hair loss and anxiety, trying treatments like topical finasteride, rosemary oil, caffeine, microneedling, low-level laser therapy, scalp massages, ketoconazole shampoo, and various vitamins. They are concerned about potential gynecomastia and are considering using minoxidil if current treatments don't stop hair loss or promote regrowth.