Induced Mammary Epithelial Cell-Derived Extracellular Vesicles Promote the Repair of Skin Trauma

    October 2025 in “ International Journal of Molecular Sciences ”
    Shufen Pan, Dandan Zhang, Guodong Wang, Longfei Sun, Mengzhen Wei, Shan Deng, Jianwei Chen, Prasanna Kallingappa, Xiang Yuan, Ben Huang
    This study demonstrates that extracellular vesicles from chemically induced mammary epithelial cells (CiMECs-EVs) can effectively promote skin wound repair. By combining CiMECs-EVs with a chitosan hydrogel to create a composite repair system (CMECG), researchers observed significant improvements in wound healing in a rat model. The CMECG system enhanced wound closure efficiency to 90% compared to 70% in the control group by day 14. The system facilitated fibroblast and mammary epithelial cell proliferation and migration, restored skin layer continuity, and promoted collagen synthesis and remodeling. The healing effects are linked to miRNAs within CiMECs-EVs, which regulate cell proliferation, migration, angiogenesis, and inflammation, involving pathways like MAPK, PI3K-Akt, and TGF-β. This novel EV-chitosan hydrogel system offers a promising therapeutic strategy for clinical skin wound repair.
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