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GlossaryNeurosyphilis

infection spreads to nervous system causing severe neurological symptoms

Neurosyphilis is a severe, late-stage manifestation of syphilis, a sexually transmitted infection caused by the bacterium Treponema pallidum. It occurs when the infection spreads to the nervous system, potentially leading to symptoms such as headaches, altered mental status, sensory deficits, and even paralysis. Early diagnosis and treatment with antibiotics are crucial to prevent irreversible damage.

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research Mixed-pattern, essential syphilitic alopecia, uveitis, and papillitis in an immunocompetent patient with neurosyphilis

1 citations , July 2025 in “Dermatology Reports”

Syphilis treatment resolved hair loss and eye symptoms, highlighting its importance in diagnosing unusual alopecia.

research Dilated tonic pupils with tabes dorsalis in neurosyphilis as first manifestation of HIV/AIDS: a video report

1 citations , March 2018 in “BMJ case reports”

Dilated pupils can be an early sign of HIV/AIDS.

research A case of neurosyphilis with inflammation of the oral mucosa

1 citations , January 2017 in “Japanese Journal of Oral & Maxillofacial Surgery”

The woman was cured of neurosyphilis after treatment with penicillin.

research Syphilis: A great imitator

35 citations , January 2019 in “Clinics in Dermatology”

Syphilis has a wide range of symptoms that can look like other diseases, and if not treated, it can progress to a more serious stage, especially in HIV-positive patients.

research 31-Year-Old Woman With Chronic Daily Headache and Alopecia

1 citations , January 2013 in “Mayo Clinic Proceedings”

A woman's chronic headaches and hair loss were cured by treating her syphilis.

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