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GlossaryOlfactory Receptor

specialized protein in the nose that detects odors

An olfactory receptor (OR) is a specialized protein found in the sensory neurons of the nose that detects odor molecules. When an odor molecule binds to an olfactory receptor, it triggers a signal that is sent to the brain, allowing us to perceive and identify different smells. These receptors are part of a large family of G-protein-coupled receptors and are crucial for the sense of smell.

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Activation of Olfactory Receptor 2A4/7 by Cyclohexyl Salicylate Promotes Human Hair Follicle Growth

research 572 Olfactory Receptor 2A4/7 Activation by the Fragrance, Cyclohexyl Salicylate, Promotes Human Hair Follicle Growth and Stem Cell Progeny Expansion

November 2022 in “Journal of Investigative Dermatology”

The fragrance cyclohexyl salicylate helps promote hair growth and increase hair stem cell numbers.

Treatment With Cyclohexyl Salicylate, an Olfactory Receptor 2A4/7 Agonist, Promotes Human Hair Follicle Growth and Bulge Stem Cell Progeny Expansion

research 732 Treatment with cyclohexyl salicylate, an olfactory receptor 2A4/7 agonist, promotes human hair follicle growth and bulge stem cell progeny expansion

July 2022 in “Journal of Investigative Dermatology”

Cyclohexyl salicylate promotes human hair growth and increases certain hair follicle stem cell progeny.

STAT5 Activation in the Dermal Papilla Is Important for Hair Follicle Growth Phase Induction, Hair Follicle Regeneration, and Wound Healing

research 219 STAT5 activation in the dermal papilla is important for hair follicle growth phase induction, hair follicle regeneration and wound healing

1 citations , August 2016 in “Journal of Investigative Dermatology”

Activating STAT5 in the skin's dermal papilla is key for starting hair growth, regenerating hair follicles, and healing wounds.

Topical Odorant Application of the Specific Olfactory Receptor OR2AT4 Agonist, Sandalore, Improves Telogen Effluvium-Associated Parameters

research Topical odorant application of the specific olfactory receptor OR2AT4 agonist, Sandalore^®, improves telogen effluvium‐associated parameters

11 citations , July 2020 in “Journal of Cosmetic Dermatology”

Sandalore® improves hair growth and quality in people with hair loss.

research Olfactory receptor OR2AT4 regulates human hair growth

82 citations , September 2018 in “Nature Communications”

A certain smell receptor in hair follicles can affect hair growth when activated by a synthetic sandalwood scent.

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community Sandalore: a scientific homemade approch

18 upvotes 7 years ago

The post discusses using Sandalore as a potential hair loss treatment, emphasizing precise measurements and safe handling. The user compares Sandalore's effects to Minoxidil and mentions preparing a solution with ethanol and DMSO.

community Sandalore experiment

17 upvotes 7 years ago

A user added sandalore to minoxidil for hair loss, observing some vellus hair growth and less scalp inflammation. Others tried sandalore with mixed results, discussing dosage and effectiveness compared to minoxidil and finasteride.

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