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Glossaryoncogene

gene that can cause cancer when mutated or overexpressed

An oncogene is a type of gene that, when mutated or expressed at high levels, can transform a normal cell into a cancerous one. In simpler terms, it's like a switch that, when turned on incorrectly, can lead to uncontrolled cell growth and potentially cancer. For professionals, oncogenes are often derived from proto-oncogenes, which are normal genes involved in cell growth and division, but become harmful when altered.

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research Conditional expression of the ErbB2 oncogene elicits reversible hyperplasia in stratified epithelia and up-regulation of TGFα expression in transgenic mice

150 citations , June 1999 in “Oncogene”

Molecular Mechanisms of Viral Oncogenesis in Humans

research Molecular mechanisms of viral oncogenesis in humans

141 citations , August 2018 in “Nature Reviews Microbiology”

Some viruses can cause cancer by changing cell processes and avoiding the immune system; vaccines and targeted treatments help reduce these cancers.

A Novel Mouse Model Demonstrates That Oncogenic Melanocyte Stem Cells Engender Melanoma Resembling Human Disease

research A novel mouse model demonstrates that oncogenic melanocyte stem cells engender melanoma resembling human disease

67 citations , November 2019 in “Nature Communications”

Oncogenic melanocyte stem cells can develop into melanoma similar to human cases.

Oncogenic Senescence: A Multi-Functional Perspective

research Oncogenic senescence: a multi-functional perspective

32 citations , February 2017 in “Oncotarget”

Cellular senescence has both cancer-blocking and cancer-promoting effects, and targeting senescent cells may improve health and lifespan.

Hair Follicle Regeneration Suppresses Ras-Driven Oncogenic Growth

research Hair follicle regeneration suppresses Ras-driven oncogenic growth

17 citations , September 2019 in “Journal of Cell Biology”

Hair follicle regeneration may slow tumor growth.

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