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GlossaryOverexpression

production of a gene's product in unusually high amounts

Overexpression refers to the process where a gene is produced in higher-than-normal amounts within a cell. This can happen naturally or be induced artificially in a lab setting. In the context of hair and alopecia, overexpression of certain genes might lead to excessive hair growth or, conversely, contribute to hair loss if the overexpressed gene disrupts normal hair follicle function.

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research Targeted overexpression of parathyroid hormone-related peptide in chondrocytes causes chondrodysplasia and delayed endochondral bone formation.

478 citations , September 1996 in “Proceedings of the National Academy of Sciences”

Overexpression of PTHrP in chondrocytes causes short-limbed dwarfism and delayed bone formation in mice.

research Induction of basal cell carcinomas and trichoepitheliomas in mice overexpressing GLI-1

380 citations , March 2000 in “Proceedings of the National Academy of Sciences”

Overexpressing GLI-1 in mice skin can cause tumors like human basal cell carcinomas.

research Induction of basal cell carcinomas and trichoepitheliomas in mice overexpressing GLI-1

333 citations , March 2000 in “Proceedings of the National Academy of Sciences”

Overexpressing GLI-1 in mice skin can cause tumors like human basal cell carcinomas.

research Overexpression of parathyroid hormone-related protein in the skin of transgenic mice interferes with hair follicle development.

211 citations , February 1994 in “Proceedings of the National Academy of Sciences”

Too much parathyroid hormone-related protein in skin disrupts hair growth in mice.

research Impaired wound healing in transgenic mice overexpressing the activin antagonist follistatin in the epidermis

163 citations , October 2001 in “EMBO journal”

Overexpressing follistatin in mice delays wound healing and reduces scar size.

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