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GlossaryOncogenic Mutations

changes in DNA that can lead to cancer

Oncogenic mutations, also known as cancer-causing mutations, are changes in the DNA that can transform a normal cell into a cancerous one. These mutations often occur in genes that regulate cell growth, division, and death, such as oncogenes and tumor suppressor genes, leading to uncontrolled cell proliferation and tumor formation.

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Oncogenic Ras Mutation Induces Spatiotemporally Specific Tissue Deformation Through Converting Fluctuated Into Sustained ERK Activation

research LB1011 Oncogenic ras mutation induces spatiotemporally specific tissue deformation through converting fluctuated into sustained ERK activation

July 2022 in “Journal of Investigative Dermatology”

A specific mutation in Kras causes abnormal tissue changes by making a cell signal continuously active, which disrupts normal cell coordination.

Oncogenic Kras Induces Spatiotemporally Specific Tissue Deformation Through Converting Pulsatile Into Sustained ERK Activation

research Oncogenic Kras induces spatiotemporally specific tissue deformation through converting pulsatile into sustained ERK activation

September 2022 in “bioRxiv (Cold Spring Harbor Laboratory)”

The Kras mutation changes normal cell signals, leading to disrupted tissue structure and potential cancer.

research The genetic evolution of skin squamous cell carcinoma: tumor suppressor identity matters

6 citations , May 2016 in “Experimental Dermatology”

The type of tumor suppressor gene lost affects the behavior of skin cancer.

Development of a New Therapeutic Approach Based on Peptide Nanoparticles Delivering CRISPR-Cas9 for the Specific Targeting of KRAS Mutations

research Development of a new therapeutic approach based on peptide nanoparticles delivering CRISPR-Cas9 for the specific targeting of KRAS mutations

September 2023 in “HAL (Le Centre pour la Communication Scientifique Directe)”

Peptide nanoparticles can effectively deliver CRISPR-Cas9 to target KRAS mutations in cancer.

Acute Sensitivity of the Oral Mucosa to Oncogenic K-ras

research Acute sensitivity of the oral mucosa to oncogenic K‐ras

12 citations , March 2011 in “Journal of pathology”

Oncogenic K-ras causes rapid cancerous changes in the mouth's lining.

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