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GlossaryProliferation Index

measure of cell division rate in a given tissue

The Proliferation Index is a measure used to determine the rate at which cells are dividing and multiplying. In the context of hair and alopecia, it can help assess the growth activity of hair follicle cells, providing insights into hair health and potential treatments for hair loss. For professionals, it is often quantified using markers like Ki-67 in tissue samples to evaluate cellular activity.

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Research

5 / 1000+ results

research [Proliferation behavior of the anagen hair bulb in androgenetic alopecia before and after local administration of 17 alpha- propylmesterolone–DNA flow cytophotometry studies].

December 1990 in “PubMed”

Topical 17 alpha-propylmesterolone increases hair cell growth in androgenetic alopecia.

research Solitary, subcutaneous, fixed, firm, and fast-growing nodule

March 2022 in “JAAD case reports”

A man had a non-cancerous, fast-growing skin lump on his arm that was removed with surgery.

research Herbal Extracts Induce Dermal Papilla Cell Proliferation of Human Hair Follicles

24 citations , January 2015 in “Annals of Dermatology”

Herbal extracts may help hair grow and could be an alternative to synthetic hair loss treatments.

research Modulation of AR-FGF-2-TGF beta Axis by Cosmos caudatus Suppresses Prostatic Epithelial Proliferation in a BPH Rat Model: A Comparative Study with Finasteride

March 2026 in “Journal of Multidisciplinary Applied Natural Science”

Cosmos caudatus extract is as effective as finasteride for treating benign prostatic hyperplasia without its side effects.

Dermal β-Catenin Activity in Response to Epidermal Wnt Ligands Is Required for Fibroblast Proliferation and Hair Follicle Initiation

research Dermal β-catenin activity in response to epidermal Wnt ligands is required for fibroblast proliferation and hair follicle initiation

207 citations , March 2012 in “Development”

Skin needs dermal β-catenin activity for hair growth and skin cell multiplication.

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Community Join

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community Will PP405 need to be used indefinitely, like minoxidil?

in Research/Science 31 upvotes 9 months ago

PP405 may not need daily use like minoxidil, but finasteride might still be needed to maintain hair regrowth. PP405 reawakens dormant hair follicles, potentially offering a long-term solution, though not a permanent cure.

community Does melatonin dissolve in isopropyl alcohol

in Technology 7 upvotes 3 years ago

The conversation discusses making a topical melatonin solution for hair loss treatment, questioning if isopropyl alcohol can dissolve melatonin. Melatonin is soluble in lipids and alcohol, but it's unstable and should be mixed fresh regularly; it may help hair growth by affecting certain cellular signaling pathways and has anti-androgenic effects.

community The Cure isn't 5 years away; it's already here.

in Research/Science 1005 upvotes 1 year ago

PP405 is a new topical treatment for hair loss, showing promise in trials but still requires finasteride for maintenance. There is skepticism about its effectiveness and safety, with concerns about needing finasteride to maintain results.

community Hair theory Scar tissue and Verteporfin

in Chat 25 upvotes 2 years ago

A user suggests that deeper microneedling with Verteporfin injections might help regrow hair in areas with scar tissue, alongside a DHT blocker. Another user explains that hair loss might be due to reduced Wnt/β-Catenin signaling and suggests that treatments like Minoxidil, Finasteride, and microneedling could potentially reverse it.

community Finasteride and Eye Problems: You’re Not Going Crazy

in Finasteride/Dutasteride 503 upvotes 1 year ago

Finasteride can cause dry eyes and vision issues due to its impact on the meibomian glands. Users have mixed experiences, with some experiencing eye discomfort and others having no side effects.

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Learn

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learn Vascular Endothelial Growth Factor

learn sh-Polypeptide-7

learn Thymosin Beta 4

learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

learn Stem Cell Factor

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