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GlossaryProtein Stability

ability of a protein to maintain its functional shape

Protein stability refers to the ability of a protein to maintain its three-dimensional structure under various conditions, such as changes in temperature, pH, or the presence of chemicals. For a layperson, think of it like a puzzle that needs to stay together to work properly; if the pieces fall apart, the puzzle is useless. For professionals, protein stability is crucial because it affects the protein's functionality and its potential use in medical or industrial applications.

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Research

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research In Silico Characterization and Analysis of Clinically Significant Variants of Lipase-H (LIPH Gene) Protein Associated with Hypotrichosis

May 2023 in “Pharmaceuticals”

Three specific mutations in the LIPH gene can cause hair loss by damaging the protein's structure and function.

research Mechanism of Laccase-assisted Tyrosine Grafting on Keratin using BSA as a Model Protein

October 2021 in “Authorea (Authorea)”

New hair perming method using tyrosine is gentler and can be done with a blow-dryer.

research CosmeticPotential of a Structural Protein CopolymerBased on Silk, Elastin, and Keratin

September 2025 in “OPAL (Open@LaTrobe) (La Trobe University)”

SELP::KP improves hair strength, elasticity, and health, making it a promising hair cosmetic.

Crystallization and Preliminary X-Ray Analysis of the Human Androgen Receptor Ligand-Binding Domain with a Coactivator-Like Peptide and Selective Androgen Receptor Modulators

research Crystallization and preliminary X-ray analysis of the human androgen receptor ligand-binding domain with a coactivator-like peptide and selective androgen receptor modulators

1 citations , November 2008 in “Acta crystallographica”

Scientists successfully created and analyzed the structure of a part of the human androgen receptor with specific modulators and a peptide to understand how it binds differently in various tissues.

research Advances of Non-Ionic Surfactant Vesicles (Niosomes) and Their Application in Drug Delivery

260 citations , January 2019 in “Pharmaceutics”

Niosomes are a promising, stable, and cost-effective drug delivery system with potential for improved targeting and safety.

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Community Join

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community Creatine / Whey Protein / Finasteride Hair Loss?

in Finasteride/Dutasteride 6 upvotes 2 years ago

A 37-year-old with a receding hairline started using finasteride and plans to add minoxidil, concerned that creatine and whey protein might accelerate hair loss. Another user suggests these supplements likely don't increase testosterone or cause hair loss, advising to monitor personal experience.

community 1+ year oral dut and oral min. 2023 → 2025. No regrowth or stability, loss continues. I'm completely cooked and demoralized.

in Progress Pictures 76 upvotes 1 year ago

The user has been using oral dutasteride and minoxidil for over a year without regrowth or stability, and hair loss continues. Suggestions include checking for inflammation, considering a scalp biopsy, and trying microneedling, topical anti-androgens, or a hair transplant.

community Don't use PP405 from everychem. it is likely fake.

in Research/Science 66 upvotes 1 year ago

PP405 from Everychem is likely fake and potentially harmful, with concerns about its stability and the risk of using the wrong MPC inhibitor, which could damage hair follicles. The real PP405 was studied under strict conditions, and DIY attempts are discouraged due to unknown formulation and quality control.

community My Telogen Effluvium journey after a bad Keratin Treatment

in Female 5 upvotes 3 years ago

A user shared their experience with telogen effluvium triggered by a keratin treatment, leading to significant hair loss. They found improvement using aloe vera with rosemary, a protein and iron-rich diet, and patience.

community 5 months on Fin + RCP + Alpecin + Vitamins

in Is this regrowth? 84 upvotes 1 year ago

The conversation discusses hair regrowth using Finasteride, Alpecin shampoo, vitamins, RCP serums, and Redensyl, with noticeable improvement in the fifth month. The user experienced some shedding initially but found stability without using Minoxidil, as advised by their dermatologist.

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