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      Formulation And Evaluation Of Controlled-Release Minoxidil Nanogels For Topical Application

      research Formulation And Evaluation of Controlled-Release Minoxidil Nanogels for Topical Application

      May 2026 in “Zenodo (CERN European Organization for Nuclear Research)”
      This study focused on creating a chitosan-based minoxidil nanogel to enhance the topical treatment of alopecia by improving drug retention and targeting. The optimized nanogel, developed using the ionic gelation method and Box–Behnken design, had a particle size of 135.4 nm, a low polydispersity index, a high positive zeta potential, and an entrapment efficiency of 89.7%. It demonstrated skin-compatible pH, pseudoplastic rheological behavior, good spreadability, and physical stability. In vitro studies showed sustained drug release over 48 hours and better drug deposition compared to conventional solutions, indicating its potential as an effective treatment for alopecia.
      Formulation And Evaluation Of Controlled-Release Minoxidil Nanogels For Topical Application

      research Formulation And Evaluation of Controlled-Release Minoxidil Nanogels for Topical Application

      May 2026 in “Zenodo (CERN European Organization for Nuclear Research)”
      This study developed a chitosan-based minoxidil nanogel for improved topical delivery in treating alopecia. The optimized nanogel, created using ionic gelation and a Box–Behnken design, had a particle size of 135.4 nm, low polydispersity, high positive zeta potential, and 89.7% entrapment efficiency. It demonstrated skin-compatible pH, pseudoplastic rheological behavior, good spreadability, and physical stability. In vitro studies showed sustained drug release over 48 hours and better drug deposition compared to conventional minoxidil solutions, indicating its potential as an effective treatment for alopecia.

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      community Does anyone know the chemical formula for pelage pp405?

      in Research/Science  14 upvotes 1 year ago
      The conversation discusses the lack of public information on the chemical structure of PP405, a hair loss treatment, and the challenges of synthesizing it without a patent. It also explores a patent related to hydrogen-based topical formulations for reducing oxidative stress and inflammation.

      community Any chemists want to manufacture PP405 / JXL069? (Steps inside)

      in Research/Science  89 upvotes 6 months ago
      The conversation discusses the synthesis and potential use of JXL069 and PP405 for hair loss treatment, with skepticism about their effectiveness and concerns about safety. Users mention that JXL069 has shown no results in hair growth, and there is confusion about its identity and effectiveness compared to PP405.

      community PP405 2a study was a safety study. Some rational explaining.

      in Research/Science  22 upvotes 8 months ago
      The conversation discusses the safety study of PP405, emphasizing that early trials focus on safety rather than efficacy, and that any efficacy data from such a short study should be viewed skeptically. It also highlights that the information released is primarily for securing funding, and that meaningful efficacy results are expected in later phases.