Formulation And Evaluation Of Controlled-Release Minoxidil Nanogels For Topical Application

This study focused on creating a chitosan-based minoxidil nanogel to enhance the topical treatment of alopecia by improving drug retention and targeting. The optimized nanogel, developed using the ionic gelation method and Box–Behnken design, had a particle size of 135.4 nm, a low polydispersity index, a high positive zeta potential, and an entrapment efficiency of 89.7%. It demonstrated skin-compatible pH, pseudoplastic rheological behavior, good spreadability, and physical stability. In vitro studies showed sustained drug release over 48 hours and better drug deposition compared to conventional solutions, indicating its potential as an effective treatment for alopecia.