169 citations
,
May 2006 in “Genes & Development” This study found that keratin 17 and TNFα play interdependent roles in regulating hair follicle cycling, with TNFα required for the anagen–catagen transition and its ablation partially rescuing hair cycling defects in K17-null mice.
169 citations
,
August 2004 in “Baillière's best practice & research. Clinical obstetrics & gynaecology/Baillière's best practice and research in clinical obstetrics and gynaecology” This article discusses treatments for hirsutism and acne in women with polycystic ovary syndrome, suggesting that lower doses of current medications maintain efficacy while reducing cost and side effects, but reports no new clinical results.
169 citations
,
September 2002 in “British journal of dermatology/British journal of dermatology, Supplement” This study reports that ZD1839 (Iressa), an anticancer drug, was associated with acneiform eruptions and hair growth abnormalities due to its inhibition of epidermal growth factor receptor signaling in the skin.
169 citations
,
June 1998 in “Journal of Investigative Dermatology” This study found no significant genetic association between the 5α-reductase enzyme genes and male pattern baldness, suggesting a polygenic etiology rather than simple inheritance.
169 citations
,
August 1981 in “BMJ” This study found that while sodium valproate improved seizure control in children with epilepsy, it often led to increased weight gain, with no severe side effects like liver disease or pancreatitis reported.
168 citations
,
August 2009 in “EMBO molecular medicine” This review discusses epidermal stem cell diversity, revealing previously unrecognized differences in stem cell populations, but reports no new experimental results; it highlights the need for further exploration of stem cell interactions and quiescence.
168 citations
,
January 2005 in “Journal of Investigative Dermatology” Male and female mice have different skin thickness, and hormones affect their skin and hair growth differently.
168 citations
,
August 2000 in “American Journal of Pathology” This study suggests that fibromodulin may regulate transforming growth factor-β activity during scar formation, influencing the transition from fetal scarless repair to adult scar-forming repair in rats.
168 citations
,
December 1986 in “Cancer Chemotherapy and Pharmacology” Epirubicin is as effective as doxorubicin for cancer treatment with less heart damage, but doesn't work on doxorubicin-resistant cancers.
167 citations
,
January 2006 in “Gynecological Endocrinology” This study found that women with polycystic ovary syndrome reported a poorer health-related quality of life compared to women in the general population and patients with other medical conditions.
166 citations
,
February 2020 in “Advanced Functional Materials” This study reports that a novel programmable device delivering VEGF through miniaturized needles significantly improved healing outcomes in diabetic mice's chronic wounds compared to traditional topical treatments.
166 citations
,
April 2019 in “International Journal of Molecular Sciences” The researchers reported that they predicted associations between certain components of MSC-conditioned medium and its ability to stimulate cell migration in vitro, identifying factors affecting its biological activity.
166 citations
,
October 2018 in “Endocrine Reviews” This review discusses the effects of hormonal treatments on the physical and mental health of transgender individuals, reporting significant reductions in mental health issues following treatment, but calls for more research on long-term and nonbinary outcomes.
166 citations
,
April 2012 in “Journal of The American Academy of Dermatology” This study reviewed clinical data from 60 patients with frontal fibrosing alopecia and found increasing prevalence and generally poor response to treatment, with the cause remaining unclear.
166 citations
,
September 2011 in “The Journal of Cell Biology” This study found that the p63 transcription factor plays a role in epidermal morphogenesis by regulating Satb1 expression, impacting chromatin architecture and gene expression in epidermal progenitor cells.
166 citations
,
August 2011 in “Dermatologic Surgery” This study found that PRP combined with dalteparin and protamine microparticles may enhance hair growth by increasing hair thickness compared to PRP alone.
166 citations
,
August 2010 in “Proceedings of the National Academy of Sciences of the United States of America” This study reports a less invasive method for detecting human clock gene expression using hair follicle cells, which accurately reflects individual behavioral rhythms and suggests a time lag issue for rotating shift workers.
166 citations
,
November 2008 in “Expert Review of Endocrinology & Metabolism” This review discusses biotin and biotinidase deficiencies, their symptoms, and methods of medical management, without presenting new clinical findings.
166 citations
,
March 2007 in “Hypertension” In this study, hyperandrogenemia in young women with polycystic ovary syndrome was linked to higher blood pressure, independent of factors like age, insulin resistance, obesity, or dyslipidemia.
166 citations
,
February 2005 in “Behavioural brain research” This study found that VDR knockout mice exhibited muscle and motor impairments affecting locomotor behavior, while cognitive functions such as exploration, working memory, and anxiety appeared unaffected.
166 citations
,
July 1999 in “American Journal Of Pathology” This study found that the loss of a functional hr gene in mice leads to premature and abnormal hair follicle regression, disrupting normal hair cycling and architecture.
165 citations
,
May 2023 in “Science Advances” In this study, the researchers developed a living microecological hydrogel containing Chlorella and Bacillus subtilis that showed potential in promoting the healing of infected diabetic wounds by providing continuous oxygen delivery and anti-infective properties.
165 citations
,
February 2014 in “Phytotherapy Research” Myrtle has various health benefits and potential for medicine development.
165 citations
,
January 2014 in “Dermatology Research and Practice” This review discusses the various dermatological applications of zinc, including its use in treating infections, inflammatory dermatoses, pigmentary disorders, and neoplasias, and reports no new clinical findings.
165 citations
,
October 2013 in “Nature Communications” This study demonstrates that bioengineered salivary gland transplants can fully regenerate gland function, producing saliva and restoring normal swallowing in salivary gland-defective mice, offering potential for xerostomia treatment.
165 citations
,
September 2013 in “Contemporary Clinical Trials” 165 citations
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August 2013 in “Lasers in Surgery and Medicine” This review discusses the potential mechanisms and evidence supporting low-level laser therapy for stimulating hair growth in men and women, while noting its safety and effectiveness but needing further study on specific parameters.
165 citations
,
September 2011 in “Journal of Public Policy & Marketing” This study found that transformation expectations mediate the link between materialism and credit overuse, suggesting that materialism fosters favorable attitudes toward debt and beliefs in life changes through acquisition.
165 citations
,
January 2008 in “Journal of biomaterials science. Polymer ed.” This review outlines the various processes activated by the peptide GHK-Cu in tissue remodeling and reports improvements in skin and wound healing but notes a need for further study to fully understand these mechanisms.
165 citations
,
June 2007 in “European Journal of Cell Biology” This review discusses the various stem cell populations associated with hair follicles and their potential in regenerative medicine, highlighting differences between murine and human hair follicles but reports no new clinical results.