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research Negative Impact of Testosterone Deficiency and 5α-Reductase Inhibitors Therapy on Metabolic and Sexual Function in Men

31 citations , January 2017 in “Advances in Experimental Medicine and Biology”

Low testosterone and 5α-reductase inhibitors can harm men's metabolic and sexual health; testosterone therapy may help, but discussing 5α-RIs' side effects is important.

research Determination of rat 5α-reductase type 1 isozyme activity and its inhibition by novel steroidal oxazolines

4 citations , August 2010 in “Acta Biologica Hungarica”

New steroidal compounds moderately block an enzyme related to testosterone conversion, less effectively than finasteride.

Vitamin D: A Bridging Element for Wellness; A Case Study on Vitamin D Deficiency and Its Association with Alopecia Areata and Other Conditions

research Vitamin D: A Bridging Element for Wellness; A Case Study on Vitamin D Deficiency and its Association with Alopecia Areata and Other Conditions

December 2024 in “International Journal of Health Sciences and Research”

Vitamin D is crucial for health, and deficiency can cause hair loss and other health issues.

research Minimum Structural Requirements for Minoxidil Inhibition of Lysyl Hydroxylase in Cultured Fibroblasts

20 citations , January 1994 in “Archives of Biochemistry and Biophysics”

Minoxidil needs specific structure to block lysyl hydroxylase; exploring alternatives may keep benefits without this effect.

The 5alpha-Reductase Type 1, But Not Type 2, Gene Is Expressed in Anagen Hairs Plucked from the Vertex Area of the Scalp of Hirsute Women and Normal Individuals

research The 5alpha-reductase type 1, but not type 2, gene is expressed in anagen hairs plucked from the vertex area of the scalp of hirsute women and normal individuals

17 citations , October 2003 in “Brazilian Journal of Medical and Biological Research”

The gene SDR5A1 is found in scalp hair of both hirsute and normal individuals, but it does not explain differences in hair growth.

Disruption of the Hedgehog Signaling Pathway Contributes to Hair Follicle Cycling Deficiency in VDR Knockout Mice

research Disruption of the hedgehog signaling pathway contributes to the hair follicle cycling deficiency in Vdr knockout mice

53 citations , May 2010 in “Journal of Cellular Physiology”

Mice without Vitamin D receptors have hair growth problems because of issues in the hedgehog signaling pathway.

Pregnancy in Postpartum Estrus Induces Inflammatory Milk Production and Catagen-Specific Pup Skin Inflammation in Interleukin-10 Deficient Mice

research Pregnancy in postpartum estrus induces inflammatory milk production and catagen specific pup skin inflammation in interleukin-10 deficient mice

4 citations , July 2013 in “Journal of Dermatological Science”

Pregnancy right after giving birth in mice lacking IL-10 causes milk that leads to liver issues and hair loss in their babies.

Network Pharmacology and In Vivo Experimental Analysis for Validating the Antifibrotic Potential of Punica Granatum Leaves Against Skin Scleroderma: The Role of Oxidative Stress, Inflammation and TGF-β1/Snail 1/p-Smad 3 Signaling Pathway

research Network pharmacology and in vivo experimental analysis for validating the antifibrotic potential of Punica granatum leaves against skin scleroderma: the role of oxidative stress, inflammation and TGF-β1/Snail 1/p-Smad 3 signaling pathway

April 2026 in “Inflammopharmacology”

This study explores the antifibrotic potential of Punica granatum ethanolic leaf extract (PGEL) against skin scleroderma, focusing on oxidative stress, inflammation, and the TGF-β1/Snail 1/p-Smad 3 signaling pathway. In a rat model with 24 subjects, PGEL was administered at doses of 200 and 400 mg/kg, resulting in reduced oxidative stress and inflammation markers, such as IL-17 A, TNF-α, and MMP-9. PGEL also downregulated fibrotic markers like COL1A1 and Snail 1, and decreased TGF-β1 and p-Smad 3 levels, leading to improved dermal thickness and collagen fiber arrangement. The study suggests that PGEL, rich in compounds like ellagic acid and catechin-3-O-gallate, may offer therapeutic benefits for skin fibrosis by targeting inflammation, extracellular matrix production, and oxidative stress.

Recommendations for Treatment of Nonclassic Congenital Adrenal Hyperplasia: An Update

research Recommendations for treatment of nonclassic congenital adrenal hyperplasia (NCCAH): An update

56 citations , December 2011 in “Steroids”

The document suggests treating individuals with nonclassic congenital adrenal hyperplasia who show symptoms, especially those related to excess male hormones.

research Topical Calcipotriol versus oral vitamin D in the treatment of alopecia areata

3 citations , March 2019 in “Fayoum University Medical Journal/Fayoum University Medical Journal ”

Rubbing calcipotriol on the skin works better than taking vitamin D pills for treating mild to moderate alopecia areata.

research Vitamin D activates type A natriuretic peptide receptor gene transcription in inner medullary collecting duct cells

17 citations , April 2007 in “Kidney international”

Vitamin D boosts a specific gene activity in kidney cells that could improve heart and kidney function.

research Helpful diagnostic markers of steroidogenesis for defining hyperandrogenemia in hirsute women

14 citations , September 2007 in “Steroids”

The study concluded that androstendione and DHEA are important for diagnosing high male hormone levels in women with excessive hair growth.

research Genetic, hormonal and metabolic aspects of PCOS: an update

258 citations , July 2016 in “Reproductive Biology and Endocrinology”

The document concludes that insulin resistance is key in PCOS development and early treatment is crucial to prevent complications.

research Integrating multi-omics analyses of Nonomuraea dietziae to reveal the role of soybean oil in [(4′-OH)MeLeu]4-CsA overproduction

1 citations , July 2017 in “Microbial Cell Factories”

Adding soybean oil to Nonomuraea dietziae increases production of a beneficial compound by improving metabolism and enzyme systems.

research Vitamin D-dependent Rickets Type II

July 2023 in “Journal of medical and health studies”

A 3-year-old with vitamin D-resistant rickets and severe hair loss died despite treatment, highlighting the need for improved management of the condition.

research Vitamin D and the skin: Physiology and pathophysiology

158 citations , August 2011 in “Reviews in endocrine and metabolic disorders”

Vitamin D and its receptor regulate skin functions like cell growth, immunity, hair cycle, and tumor prevention.

research Lean Women with Polycystic Ovary Syndrome

1 citations , February 2018 in “InTech eBooks”

PCOS in lean women is a serious health condition with implications beyond fertility, affecting metabolism and increasing cardiovascular disease risk.

research Acne

4 citations , January 2019

Acne is a common skin condition that can be influenced by diet, lifestyle, and hormones, and requires a treatment approach that includes psychological considerations.

research Novel Vitamin D Receptor Mutations in Hereditary Vitamin D Resistant Rickets in Chinese

10 citations , September 2015 in “PLoS ONE”

New mutations in the VDR gene cause vitamin D-resistant rickets without hair loss.

Clinical Exome Sequencing Unveils the Genetic Landscape of Polycystic Ovarian Syndrome Focusing on Lean and Obese Phenotypes: Implications for Cost-Effective Diagnosis and Personalized Treatment

research Clinical-Exome Sequencing Unveils the Genetic Landscape of Polycystic Ovarian Syndrome (PCOS) Focusing on Lean and Obese Phenotypes: Implications for Cost-Effective Diagnosis and Personalized Treatment

June 2024 in “Research Square (Research Square)”

Young women in West Bengal, India, with PCOS often have estrogen resistance, leptin receptor issues, folate deficiency, T2DM, and acanthosis, commonly linked to obesity.

research Vitamin D receptor: molecular signaling and actions of nutritional ligands in disease prevention

271 citations , September 2008 in “Nutrition reviews”

Vitamin D receptor interacts with certain dietary components to help prevent diseases and regulate hair growth.

research The role of anemia and vitamin D levels in acute and chronic telogen effluvium

11 citations , January 2011 in “Turkish Journal of Medical Sciences”

Low iron levels are a significant risk factor for hair loss, while high vitamin D levels might be a response to hair loss, not a cause.

research Urinary steroid metabolome shows adrenal, gonadal, and neuroactive steroid dysregulation in adolescents with depression

1 citations , July 2025

Depressed teens have different steroid levels in urine, which may help identify and treat them.

Effect of Sinapic Acid on Hair Growth Promotion in Human Hair Follicle Dermal Papilla Cells via Akt Activation

research Effect of sinapic acid on hair growth promoting in human hair follicle dermal papilla cells via Akt activation

25 citations , March 2017 in “Archives of Dermatological Research”

Sinapic acid may help hair growth by activating a specific cell pathway.

research Molecular Genetic and Endocrine Mechanisms of Hair Growth

51 citations , January 2003 in “Hormone Research in Paediatrics”

Hormones and their receptors, especially androgens, play a key role in hair growth and disorders like baldness.

research Studying the genetic predisposing factors in the pathogenesis of acne vulgaris

39 citations , May 2011 in “Human Immunology”

Genetics play a role in acne, but how exactly they contribute is not fully understood.

research Acne-Associated Syndromes

January 2019 in “Springer eBooks”

Acne is linked to inflammation and insulin resistance, and is associated with various syndromes that require different treatments.

Nutrition and Hair Health: The Impact of Nutritional Deficiencies

research Nutrition and hair

70 citations , June 2010 in “Clinics in Dermatology”

Certain groups may need vitamin supplements to improve hair health and prevent other health problems.

research Oral Manifestations of Hematologic and Nutritional Diseases

50 citations , November 2010 in “Otolaryngologic Clinics of North America”

Recognizing oral symptoms can help diagnose and treat blood and nutritional diseases early.

research Oxygen, Metabolism, and Regeneration: Lessons from Mice

35 citations , October 2017 in “Trends in Molecular Medicine”

Mice with enhanced regeneration abilities may help develop new regenerative medicine therapies.

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