December 2023 in “Frontiers in pharmacology” Progesterone initially worsens but later reduces neuropathic pain in mice, through different mechanisms.
180 citations
,
June 2004 in “Journal of Pharmacology and Experimental Therapeutics” Progesterone's seizure-reducing effects are mainly due to allopregnanolone, not progesterone receptors.
2 citations
,
April 2020 in “Clinical and experimental obstetrics & gynecology” Hair levels of estradiol and progesterone are higher in premenopausal than postmenopausal women, but the difference isn't statistically significant, indicating the need for a better measurement method.
150 citations
,
November 2007 in “The Journal of Clinical Endocrinology and Metabolism” About 2.2% of women with symptoms of high male hormones have a mild form of congenital adrenal hyperplasia, and measuring a specific hormone level can accurately diagnose it.
Low-dose glucocorticoid treatment improves pregnancy and birth rates in women with nonclassical 21-hydroxylase deficiency.
9 citations
,
April 2018 in “Biology of reproduction” Diet changes hormone levels in pregnant ewes by affecting metabolism, not placental synthesis.
60 citations
,
June 2007 in “Pharmacology Biochemistry and Behavior” Blocking progesterone metabolism can cause depression-like behavior in mice.
14 citations
,
December 1998 in “The Journal of Clinical Endocrinology and Metabolism” MENT could be a better option than testosterone for male hormone therapy and birth control because it works well at lower doses and has fewer side effects on the prostate.
186 citations
,
February 1980 in “Clinical Endocrinology” During puberty, hormone levels rise, with early increases in some steroids and most menstrual cycles becoming regular by six years after menarche.
13 citations
,
July 2008 in “Biomedical Chromatography” The methods accurately measured brain androgens, showing most 5α-androstane-3α,17β-diol comes from outside the brain, while androsterone is both transported and made in the brain.
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11 citations
,
March 2008 in “Experimental Dermatology” A substance called compound-1 could help increase hair growth by maintaining prostaglandin levels in hair follicles.
July 2022 in “L Endocrinologo” A 77-year-old woman with hair loss had high testosterone and 17OH-progesterone levels, but no significant findings on imaging.
13 citations
,
May 2007 in “Journal of Endocrinology” Synthetic 19-norprogestins promote bone cell growth and function through their non-phenolic metabolites.
42 citations
,
May 2003 in “Mini-reviews in Medicinal Chemistry” New steroidal compounds could be effective for treating conditions related to 5α-reductase enzyme activity.
1 citations
,
January 2003 in “Chinese Journal of Pharmaceuticals” A new method to make Finasteride is more cost-effective and yields 16%.
2 citations
,
May 2012 in “Indian drugs” Finasteride, a hair loss treatment, works better and is more stable when delivered through specially prepared gels, leading to increased hair growth.
November 2003 in “Journal of Neurochemistry” Allopregnanolone may enhance alcohol's effects on dopamine neurons, influencing addiction risk.
September 2002 in “Fertility and sterility” Metformin can start ovulation and may lower 17P response in PCOS, but six months is too short to improve hair growth or change body fat distribution.
Blocking 11β-HSD1 reduces stress hormone damage in hair growth cells.
186 citations
,
December 2011 in “Molecules” Three specific 4-azasteroid-2-oximes showed strong enzyme inhibition, but less than finasteride.
91 citations
,
March 2021 in “Molecular and Cellular Endocrinology” CYP11A1 is crucial for skin health and disease by producing important steroids.
26 citations
,
November 2013 in “Neuroscience” Progesterone can reduce seizures without relying on the GABAA receptor pathway.
19 citations
,
July 2005 in “Steroids” Testosterone increases 3α-androstanediol levels, which can be blocked by finasteride.
17 citations
,
November 2017 in “Experimental physiology” Breathing in newborn rats is affected differently by hormones based on their sex.
18 citations
,
January 1990 in “Journal of The American Academy of Dermatology” Lower doses of dexamethasone can safely reduce high DHEAS levels in women with androgenic disorders.
12 citations
,
March 2018 in “Analytical chemistry” Researchers created a new method to measure brain steroids, finding higher levels of certain steroids and changes due to a drug.
3 citations
,
January 2017 in “Yonsei Medical Journal” Blocking 11β-HSD1 can lessen the harmful effects of glucocorticoids on hair growth cells.
May 2006 in “Frontiers in Neuroendocrinology” Progesterone and its metabolites affect myelin protein expression differently in male and female rat Schwann cells.
5 citations
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June 2010 in “Universitas Psychologica” Progesterone helps protect against stress-related memory and behavior issues in rats.