research Highly Upregulated Lhx2 in the Foxn1−/− Nude Mouse Phenotype Reflects a Dysregulated and Expanded Epidermal Stem Cell Niche
The Foxn1(-/-) nude mouse shows disrupted and expanded skin stem cell areas due to high Lhx2 levels.
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research Effects of ultraviolet B radiation on physicochemical properties of human hair shaft
UVB radiation changes the chemical makeup and dries out human hair but doesn't alter its appearance or texture.
research Finasteride-related Leydig cell tumour: report of a case and literature review
Finasteride use may be linked to rare testicular tumor, but more research needed.
research Beneficial uses of Breadfruit (Artocarpus altilis)
Breadfruit is nutritious and has potential health and medicinal benefits, but is currently underused.
research Extraordinary claims without extraordinary evidence: controversy on anti‐androgen therapy for COVID‐19
The letter is skeptical about the effectiveness of anti-androgen therapy for COVID-19 and calls for strong evidence from clinical trials.
research Hair whitening in a patient with psoriasis on adalimumab reversed after switching to ixekizumab
Switching from adalimumab to ixekizumab improved a patient's psoriasis and reversed hair whitening.
research Development of a Liquid Chromatography/Mass Spectrometry-Based Inhibition Assay for the Screening of Steroid 5-α Reductase in Human and Fish Cell Lines
A new method was created to test the effectiveness of Dihydrotestosterone (DHT) inhibitors, like finasteride and dutasteride, in human and fish cells. The results showed fish cells are more sensitive to these treatments, and dutasteride works better than finasteride in all tested cells.
research Blockade of Androgen Markers Using a Novel Betasitosterol, Thioctic Acid and Carnitine-containing Compound in Prostate and Hair Follicle Cell-based Assays
The new compound was more effective than finasteride in reducing markers of hair loss and prostate issues in cell tests.
research Steroid Hormones
Steroid hormones are crucial for body functions and have various medical uses, but their misuse can lead to dependence.
research A Hair Growth-Promoting Effect of Chinese Black Tea Extract in Mice
Chinese black tea extract helped mice grow hair, especially when combined with capsaicin.
research Hairless or fertile? Finasteride leads to epididymal changes and infertility in rats
Finasteride may cause infertility in rats by affecting epididymis and sperm function.
research Is the “Comb Over” Dying? A Mouse Model for Male Pattern Baldness (Androgenic Alopecia)
The mouse model suggests male pattern baldness may be due to an enzyme increasing DHT and higher androgen receptor levels in hair follicles.
research Effects of finasteride on the morphology of polycystic ovaries
Finasteride doesn't change polycystic ovary size or cyst number, suggesting testosterone's role in their appearance.
research Effect of dose reduction of dutasteride in combination with alpha-blockers in patients with lower urinary tract symptoms/benign prostatic enlargement
Taking dutasteride every other day works as well as daily and better preserves sexual function.
research Discriminating in favour of or against men with increased risk of finasteride-related side effects?
Finasteride treats baldness but may cause lasting sexual side effects.
research The role of 5-alpha-reductase inhibitors in active surveillance
5-alpha-reductase inhibitors might help slow down low-risk prostate cancer, but their use should be cautious.
research Reply
The document concludes that doctors should monitor children's brain development when treating hemangiomas with interferon alfa and consider stopping the treatment if problems arise, while also exploring drugs that might counteract side effects.
research Letter to the Editor on “COVID-19 Infection in Men on Testosterone Replacement Therapy”
The letter suggests testosterone replacement therapy might worsen COVID-19 outcomes.
research Unknown safety profile of ingredients in hair supplements: A call to action for improved patient safety
The conclusion is that hair supplement ingredients may be unsafe and should be disclosed and proven safe before use.
research Effect of ethanol extract of Zapoteca portoricensis stem on liver, kidney and prostatic biomarkers of testosterone-induced benign prostate hyperplasia (BPH) in male albino rats
Zapoteca portoricensis extract may help protect against prostate issues and support liver and kidney health in rats.
research Minoxidil Use in Alopecia
Minoxidil helps stimulate hair growth and enlarge small follicles in common hair loss, but doesn't stop it, and its effects can be boosted when combined with finasteride.
research Genetic analysis of 5 α reductase type 2 enzyme in relation to oxidative stress in cases of androgenetic alopecia in a sample of egyptian population
5α reductase type 2 enzyme mutation and oxidative stress may increase androgenetic alopecia risk in Egyptians.
research Cutaneous drug reactions
Any drug can cause skin reactions, but antibiotics, NSAIDs, and psychotropic drugs are more common, with some reactions being life-threatening.
research In Silico Structure-Based Drug Design Approach To Evaluate Quercetin And Kaempferol As Dual Inhibitors Of Jak3 Kinase And 5-Alpha Reductase Type II with ADMET Profiling
Quercetin and kaempferol may be effective and safe natural treatments for hair loss.
research In Silico Structure-Based Drug Design Approach To Evaluate Quercetin And Kaempferol As Dual Inhibitors Of Jak3 Kinase And 5-Alpha Reductase Type II with ADMET Profiling
Quercetin and kaempferol may be effective and safe natural treatments for hair loss.
research An exploratory analysis of 5‐alpha reductase inhibitors and risk of opioid use disorder among male Medicare beneficiaries receiving prescription opioid medications
Using 5-alpha reductase inhibitors may lower the risk of opioid addiction in men taking opioids.
research Preparation, Characterization and Molecular Docking Study of some New Pyrazole Derivatives Derived from 2-Mercaptobenzothiazole.
New pyrazole derivatives may help treat hair loss, but more testing is needed.
research African Journal of Biomedical Research
Olive leaves extract may help treat benign prostatic hyperplasia (BPH).
research 5-Alpha-Reductase Inhibitors in the Treatment of Male Androgenetic Alopecia: Clinical Experience
Low-dose dutasteride effectively and safely promotes hair growth in men with androgenetic alopecia.
research (291) The Effect of Administration and Discontinuation of Finasteride in Male Rats
Finasteride's negative effects on brain tissue in male rats may be reversible after stopping the drug.