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The wavy coat in NCT mice is caused by multiple genes, including a mutation in the Prss53 gene.

Enzyme replacement therapy improved multiple symptoms of homocystinuria in mice.

Scientists successfully created and analyzed the structure of a part of the human androgen receptor with specific modulators and a peptide to understand how it binds differently in various tissues.

Rapamycin treatment helps with mitochondrial disease by reducing PKC levels.

Enobosarm significantly increased muscle mass and improved physical function in elderly men and postmenopausal women without serious side effects.

Non-immune factors play a significant role in alopecia areata.

Retinoids increase steroid sulfatase activity in leukemia cells through RARα/RXR and involves certain pathways like phosphoinositide 3-kinase and ERK-MAP kinase.

Targeting ACE2 and TMPRSS2 may help prevent or treat COVID-19 in cancer patients.

A unique enzyme in guinea pig hair follicles helps form protein cross-links in hair.

Caspases affect many cell functions and could help treat various diseases.

Pantethine may boost the immune system's ability to fight sarcoma.

Accurate protein modeling can help develop new treatments for prostate cancer and other diseases.

ZDHHC13 is important for normal liver function and metabolism, affecting mitochondrial activity.

The study mapped keratin 15 and 19 genes, aiding future genetic disorder research.

Caspases do more than kill cells; they also help in cell growth and disease, and targeting them could lead to new treatments.

A new mRNA variant of the SCF gene in sheep skin produces a shorter, different protein.

KRTAP28-1 gene can help breed sheep with finer wool.

PLIN2 affects hair growth in cashmere goats, potentially improving cashmere quality.

The KRTAP22-2 gene in sheep does not significantly affect wool traits.

Compound 7p shows strong potential as an anticancer agent.

The document concludes that understanding sulfation biology is crucial for creating treatments due to its importance in biological functions and disease.

Cathepsin L is essential for normal hair growth and development.

Overexpression of PKCepsilon leads to increased TNFalpha, promoting metastatic squamous cell carcinoma in mice.

ATP-dependent chromatin remodeling is crucial for skin development and stem cell function.

Lysosomal proteases and cytoplasmic enzymes help hair follicle cells develop and differentiate.

A new compound slows cancer cell growth and causes cell death by blocking cell cycle progression and increasing cell-damaging molecules.

The compound GD-23 may reduce anxiety like diazepam by targeting the TSPO receptor.