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research 17-Oximino-5-androsten-3β-yl esters: synthesis, antiproliferative activity, acute toxicity, and effect on serum androgen level

7 citations , August 2010 in “Medicinal Chemistry Research”

Some synthesized compounds were more effective than Finasteride in reducing prostate cancer cell growth and androgen levels.

research Is Dihydrotestosterone a Classic Hormone?

4 citations , June 2017 in “Endocrine Reviews”

Dihydrotestosterone (DHT) mainly affects nearby cells, doesn't significantly change prostate hormonal environment or cancer risk, and doesn't play a main role in causing hair loss or acne. More research is needed on its effects on heart health, sexual function, and bone health.

research Evaluation of dihydrotestosterone levels and total testosterone to dihydrotestosterone ratio with clinical symptoms and metabolic parameters in patients with polycystic ovary syndrome

November 2025 in “BMC Endocrine Disorders”

The TT/DHT ratio may help identify PCOS patients with severe metabolic issues.

research Exogenous Alpha-Ketoglutaric Acid Alleviates the Rabbit Dermal Papilla Cell Oxidative Damage Caused by Hydrogen Peroxide Through the ERK/Nrf2 Signaling Pathway

4 citations , April 2025 in “Antioxidants”

Alpha-ketoglutarate protects rabbit skin cells from oxidative damage by activating a specific cell pathway.

A Randomized, Active- and Placebo-Controlled Study of the Efficacy and Safety of Different Doses of Dutasteride Versus Placebo and Finasteride in the Treatment of Male Subjects with Androgenetic Alopecia

research A randomized, active- and placebo-controlled study of the efficacy and safety of different doses of dutasteride versus placebo and finasteride in the treatment of male subjects with androgenetic alopecia

97 citations , January 2014 in “Journal of The American Academy of Dermatology”

Dutasteride 0.5 mg works better than finasteride and placebo for increasing hair in men with hair loss.

research Differential expression of steroid 5α-reductase isozymes and association with disease severity and angiogenic genes predict their biological role in prostate cancer

30 citations , June 2010 in “Endocrine Related Cancer”

SRD5A1 is crucial in advanced prostate cancer, and blocking both SRD5A1 and SRD5A2 is more effective than targeting SRD5A2 alone.

research The expression of inducible nitric oxide synthase (iNOS) in the testis and epididymis of rats with a dihydrotestosterone (DHT) deficiency

28 citations , January 2009 in “Cellular & Molecular Biology Letters”

DHT deficiency increases iNOS expression in rat testis and epididymis.

research Role of 5α-reductase inhibitors in androgen-stimulated skin disorders.

3 citations , February 2013 in “PubMed”

5α-reductase inhibitors like finasteride and dutasteride can help treat skin disorders stimulated by androgens, such as hair loss and acne.

research In vitro 5α-reductase inhibition by selected Ayurvedic herbs for androgenic disorders

October 2024 in “International Journal of Ayurveda Research”

Emblica officinalis and Eclipta alba may help treat hair loss naturally.

research IMPROVEMENT OF ALOPECIA AND DECREASES IN HAIR CORTISOL AND DIHYDROTESTOSTERONE CONCENTRATIONS AFTER THE TOPICAL USE OF PLANT EXTRACTS IN MEN WITH ANDROGENETIC ALOPECIA

August 2021 in “Asian Journal of Pharmaceutical and Clinical Research”

Plant extracts in shampoo improved hair thickness and density in men with hair loss.

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