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TGF-β1 increases androgen receptor activity in hair loss, but Hic-5/ARA55 can counter this effect.

A 5-year-old girl's scalp scarring and hair loss from lupus improved with specific medications.

The enzymes 5α-reductase and 3α/β-hydroxysteroid oxidoreductase help create brain-active substances from progesterone and testosterone, which could be used for treatment, but more research is needed to ensure their safety and effectiveness.

New treatments for enlarged prostate are being developed, some of which may be more effective than current medications.

Minoxidil 5% caused skin discoloration in a man using it for hair loss.

Researchers developed a new method to find substances in herbs that can block a specific enzyme linked to hair loss.

A chimeric keratin partially improved skin structure in mice lacking keratin 5, but didn't fully restore normal skin.

Finasteride helps protect brain in old male rats.

Adding low-level light therapy to minoxidil improves hair growth and patient satisfaction.

The equine epididymis mainly uses type 1 5α-reductase, and both finasteride and dutasteride can inhibit its activity.

Imiquimod 5% cream may not work for treating scrotal extramammary Paget disease.

Blocking 5α-reductase can harm memory and brain structure, and increase harmful brain changes in male mice used for Alzheimer's disease research.

All five human steroid 5α-reductase enzymes are found in the endoplasmic reticulum.

Minoxidil 5% solution significantly improved hair density in a girl with loose anagen hair syndrome over 28 months, with no side effects.

A new method was developed to measure and assess the activity and inhibition of the enzyme steroid 5α-reductase.

The activity of a specific rat enzyme in the prostate and epididymis is highly dependent on the acidity level.

Finasteride raises suicide-linked aggression and stops clozapine's positive effects in schizophrenia animals.

Some curcumin-like compounds can effectively and safely block the enzyme linked to hair loss and other conditions related to male hormones.

A new mouse mutation causes skin and hair defects due to a gene change.

Dutasteride reduces DHT more effectively than finasteride.

Finasteride 5-mg oral disintegrating tablets and standard tablets are bioequivalent in healthy adult male Han Chinese volunteers.

The 5% minoxidil solution effectively treated hair loss with good tolerability.

Finasteride doesn't affect antipyrine metabolism, so interactions with cytochrome P-450 enzyme drugs are unlikely.

Finasteride reduces opioid use and withdrawal symptoms in animals.

11α-Hydroxyprogesterone is changed into different substances by certain enzymes and may play a role in prostate cancer.

Eclipta prostrata helps hair growth and maintains the growth phase by affecting certain growth factors.

Inhibiting 5α-reductase increases progesterone levels in late pregnant mares.

Taking 5 mg/day finasteride can cause side effects in women with hair loss, but these are usually mild and fade over time, making the treatment beneficial in the long run.

Finasteride negatively affects fish reproduction and gonadal development.

Steroid 5α-reductase evolved from protists and diversified in eukaryotes, with specific roles in mammals and plants.