research Oral Testosterone in Oil: Pharmacokinetic Effects of 5 Reduction by Finasteride or Dutasteride and Food Intake in Men
Taking oral testosterone with finasteride or dutasteride doubles testosterone levels, and food slightly affects it.
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research Effect of ethanol extract of plant mixture on hair regeneration in human dermal papilla cells and C57BL/6J mice
A plant mixture extract helped grow hair by boosting cell growth and growth factors while blocking a hair loss-related enzyme.
research Extensive Challenges and Pending Advances in the Study of 5-Alpha-Reductase Isoenzymes. A Literature Review
5α-reductase enzymes are crucial in certain disorders, and while treatment advances exist, more research on SRD5A3 is needed.
research The Implication of Neuroactive Steroids in Tourette's Syndrome Pathogenesis: A Role for 5α‐Reductase?
Neuroactive steroids and the enzyme 5α-reductase might be involved in the development of Tourette's syndrome.
research Null Mutation of 5α-Reductase Type I Gene Alters Ethanol Consumption Patterns in a Sex-Dependent Manner
research Testosterone Metabolism in Human Skin Cells in vitro and Its Interaction with Estradiol and Dutasteride
Different skin cells process testosterone differently, and certain drugs can change this process, possibly helping treat acne and hair loss.
research Ficus benghalensis as Potential Inhibitor of 5α-Reductase for Hair Growth Promotion: In Vitro, In Silico, and In Vivo Evaluation
Ficus benghalensis leaf extracts can effectively promote hair growth and inhibit hair loss.
research Skin Manifestations of Insulin Resistance: From a Biochemical Stance to a Clinical Diagnosis and Management
Certain skin conditions can indicate insulin resistance and should prompt lifestyle changes and medical treatment to manage underlying health issues.
research Lipidomics Combined with Network Pharmacology to Explore Differences in the Mechanisms of Grey Hair Development Between Type 2 Diabetes Mellitus and Normal Populations (Female)
Altered lipid pathways in diabetic women may cause premature greying.
research Molecular Interactions of New Pregnenedione Derivatives
The new progesterone derivatives effectively inhibit 5α-reductase and bind to the androgen receptor.
research Saw palmetto and finasteride in the treatment of category-iii prostatitis/chronic pelvic pain syndrome
Saw palmetto helps with nighttime urination and urine flow, similar to finasteride.
research 6 Peripheral androgens and the role of androstanediol glucuronide
Androstanediol glucuronide is a reliable marker for hirsutism in women.
research Polycystic ovary syndrome
The document concludes that managing PCOS involves treating symptoms and reducing long-term metabolic risks, with lifestyle changes being important.
research 5α-Reductase Isoenzymes: From Neurosteroid Biosynthesis to Neuropsychiatric Outcomes
Finasteride and dutasteride may cause depression and anxiety, especially in younger men.
research In Vitro and In Vivo Regulation of SRD5A mRNA Expression of Supercritical Carbon Dioxide Extract from Asparagus racemosus Willd. Root as Anti-Sebum and Pore-Minimizing Active Ingredients
Asparagus racemosus root extract reduced sebum and pore size in men but not in women.
research RE-ORGA, a Korean Herb Extract, Can Prevent Hair Loss Induced by Dihydrotestosterone in Human Dermal Papilla Cells
RE-ORGA, a Korean herb extract, may help prevent hair loss.
research Overexpression of aldo-keto reductase 1C3 (AKR1C3) in LNCaP cells diverts androgen metabolism towards testosterone resulting in resistance to the 5α-reductase inhibitor finasteride
Too much AKR1C3 enzyme causes resistance to finasteride by increasing testosterone.
research Effect of Fenugreek Extract on Testosterone Propionate-Induced Benign Prostatic Hyperplasia
Fenugreek extract may help treat benign prostatic hyperplasia.
research The Impact of 5α-Reductase Inhibitor Use for Male Pattern Hair Loss on Men’s Health
Hair loss drugs may cause sexual issues and infertility in men.
research Kyoh® Rocket Leaf Extract Regulates Proliferation and VEGF and FGF7 Expression in Human Dermal Follicle Papilla Cells
Kyoh® rocket leaf extract may promote hair growth naturally with fewer side effects.
research Systematic review: interventions in sickle cell disease-related priapism in reducing overall morbidity, recurrence, and side effects
More research is needed to find effective treatments for sickle cell disease-related priapism.
research Associations between semen quality and lower urinary tract symptoms in ageing male
The conclusion is that doctors should be careful when prescribing 5α-reductase inhibitors due to possible serious side effects, and they should discuss these risks with patients.
research The 5α-reductase inhibitor finasteride is not associated with alterations in sleep spindles in men referred for polysomnography
Finasteride doesn't affect sleep spindles in men.
research Efficacy and Side Effects of Drugs Commonly Used for the Treatment of Lower Urinary Tract Symptoms Associated With Benign Prostatic Hyperplasia
Different drugs for prostate-related urinary symptoms work but have various side effects, and treatment should be tailored to the individual.
research Trazodone by epigenetic mechanism can reverse the post finasteride syndrome
Trazodone might help reverse post finasteride syndrome.
research Finasteride treatment and neuroactive steroid formation.
Finasteride treatment can decrease certain steroids and increase others, possibly leading to depression symptoms in some cases.
research Pharmacological Approaches in Managing Symptomatic Relief of Benign Prostatic Hyperplasia: A Comprehensive Review
Tadalafil is effective for treating urinary symptoms in men with BPH.
research Adverse Effects of 5-Alpha Reductase Inhibitor Therapy in Men With Androgenetic Alopecia: Is There Cause for Concern?
5-alpha reductase inhibitors may cause sexual side effects, breast complications, and other health risks in men with hair loss.
research Formulation and Evaluation of Herbal Cream for the Management of Androgenetic Alopecia
The herbal hair cream could help treat male pattern baldness by blocking a baldness-related enzyme and might be worth further investigation.
research Serenoa repens and N‐acetyl glucosamine/milk proteins complex differentially affect the paracrine communication between endothelial and follicle dermal papilla cells
Serenoa repens and N-acetyl glucosamine/milk proteins complex may help with hair growth and prevent hair loss.