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Retinoids increase steroid sulfatase activity in leukemia cells through RARα/RXR and involves certain pathways like phosphoinositide 3-kinase and ERK-MAP kinase.

Gene variant linked to prostate cancer, hormone levels, and hair loss.

Human skin can make serotonin and melatonin.

A brominated phenoxy compound effectively inhibits a human enzyme and shows potential for clinical use.

Mutations in the SRD5A3 gene cause a new type of glycosylation disorder by blocking the production of a molecule necessary for protein glycosylation.

New compounds were made and tested, with compound 6 showing potential for treating prostate-related diseases.

CYP154C7 enzyme can effectively modify steroids and is promising for commercial use.

Monocyclic aromatic compounds are important for developing various drugs and treatments.

Researchers made two new compounds that could be used for medicine.

The compound 4c showed strong potential as an anticancer agent.

Mouse skin can produce and process serotonin, with variations depending on hair cycle, body location, and mouse strain.

Finasteride was successfully synthesized from Pregnadienolone acetate.

Higher SRD5A2 expression predicts better response to finasteride in treating urinary symptoms.

Prostate cells have proteins that bind to specific hormones, which can increase protein production when activated by these hormones.

PEA boosts allopregnanolone production and reduces oxidative stress in brain cells.

A new method efficiently creates biaryl N-oxides with potential for cancer treatment and drug development.

Dihydrotestosterone can be made from dehydroepiandrosterone in skin cells without needing testosterone.

This enzyme helps metabolize fatty acids and isoleucine, and could be key in treating neurological diseases and certain cancers.

5α-reductase enzyme affects hormone levels, influencing conditions like acne and hair loss.

Lack or blocking of SRD5a, a key component in hormone creation, can lead to conditions like pseudohermaphrodism and affect hair growth, bone mass, muscle strength, and reproductive health. More research is needed on its regulation from fertilization to adulthood.

The development of breeding tubercles in male zebrafish relies on a specific enzyme that processes hormones.

Poly(ADP-ribose) synthesis is linked to skin cell differentiation.

The research found that compound 6, a newly created steroid, is more effective at inhibiting 5α-reductase (an enzyme) than current treatments, suggesting it could be a better option for treating urinary tract symptoms in men.

A new enzyme in rats may help regulate hair growth.

The PTGER2 gene is highly active in Cashmere goat skin and its activity changes with the hair growth cycle.

Some prostate cancers have gene changes that may affect treatment with certain drugs.

Overexpressing COX-2 in mice skin reduces skin tumor development.

The study found ways to create important compounds for male health from olive waste.

A protein made in a plant stopped hair growth in mice.