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research 546 Gene expression signatures and ALADIN score correlates with response of alopecia areata patients to treatment with JAK inhibitors

April 2016 in “The journal of investigative dermatology/Journal of investigative dermatology”

The ALADIN score can predict how well patients with alopecia areata will respond to JAK inhibitor treatments.

research Effects of the PI3K/Akt signaling pathway on the hair inductivity of human dermal papilla cells in hair beads

12 citations , April 2022 in “Journal of Bioscience and Bioengineering”

Activating the PI3K/Akt pathway improves hair growth by human dermal papilla cells in hair beads.

research Keratinocyte integrin α3β1 induces expression of the macrophage stimulating factor, CSF-1, through a YAP/TEAD-dependent mechanism.

8 citations , February 2024 in “Matrix Biology”

research JAK1 Signaling Is Involved in the Induction of Mechanical Alloknesis in Atopic Dermatitis

November 2025 in “Biomedicines”

JAK1 inhibitors can help reduce itchiness in atopic dermatitis.

research Bone morphogenetic protein signaling regulates the size of hair follicles and modulates the expression of cell cycle-associated genes

92 citations , November 2006 in “Proceedings of the National Academy of Sciences of the United States of America”

BMP signaling controls hair follicle size and cell growth by affecting cell cycle genes.

research Wnt signaling: the good and the bad

48 citations , July 2008 in “Acta Biochimica et Biophysica Sinica”

Wnt signaling is important for development and cell regulation but can cause diseases like cancer when not working properly.

Epidermal Wnt/Beta-Catenin Signaling Promotes Dermal Adipocyte Differentiation During Hair Follicle Morphogenesis and Regeneration

research Epidermal Wnt/beta-catenin signalling promotes dermal adipocyte differentiation during hair follicle morphogenesis and regeneration

December 2012 in “Journal of Dermatological Science”

Wnt/beta-catenin signaling in the skin helps fat cell development during hair growth and repair.

research Potential relationship between the canonical Wnt signalling pathway and expression of the vitamin D receptor in alopecia

21 citations , March 2014 in “Clinical and experimental dermatology”

Targeting the Wnt pathway might help treat hair loss.

research Inhibition of Bmp signaling affects growth and differentiation in the anagen hair follicle

305 citations , December 2000 in “The EMBO Journal”

Inhibiting Bmp signaling disrupts hair growth and differentiation.

research The Wave complex controls epidermal morphogenesis and proliferation by suppressing Wnt–Sox9 signaling

22 citations , March 2019 in “The Journal of Cell Biology”

The Wave complex controls skin growth by suppressing certain signals.

research Investigating the role of notch ligands regulating epidermal stem cell differentiation

January 2025 in “eScholarship@McGill (McGill)”

research Activation of the Notch pathway in the hair cortex leads to aberrant differentiation of the adjacent hair-shaft layers

109 citations , June 2000 in “Development”

Notch pathway activation causes abnormal hair layer development.

research BMP4 and nuclear laminC orchestrate a expression of AHF/Trichohyalin molecule, a key modulator of keratin intermediate filaments in the hair follicle

January 2007

research β1 Integrin Signaling Maintains Human Epithelial Progenitor Cell Survival In Situ and Controls Proliferation, Apoptosis and Migration of Their Progeny

20 citations , December 2013 in “PLoS ONE”

β1 integrin is essential for the survival, growth, and movement of human epithelial progenitor cells.

research Regulating the Regulators: Routing the Wnt-β-Catenin–Lef Signals

5 citations , July 2004 in “Journal of Investigative Dermatology”

Understanding Wnt-β-catenin signaling is key to hair growth and could impact conditions like baldness.

research Aberrant Wnt Signaling Induces Comedo-Like Changes in the Murine Upper Hair Follicle

4 citations , December 2021 in “The journal of investigative dermatology/Journal of investigative dermatology”

Overactive Wnt signaling in mouse skin stem cells causes acne-like cysts and shrinking oil glands, which some treatments can partially fix.

research Faculty Opinions recommendation of Bone morphogenetic protein antagonist noggin promotes skin tumorigenesis via stimulation of the Wnt and Shh signaling pathways.

December 2009 in “Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature”

Noggin promotes skin tumors by activating Wnt and Shh pathways.

Regulatory Effect of Beta-Catenin on Proliferation of Hair Follicle Stem Cells Involves PI3K/Akt Pathway

research Regulatory effect of β-catenin on proliferation of hair follicle stem cells involves PI3K/Akt pathway

11 citations , March 2013 in “Journal of Applied Biomedicine”

β-catenin helps hair follicle stem cells grow by activating a specific cell pathway.

research The CLE40 and CRN/CLV2 Signaling Pathways Antagonistically Control Root Meristem Growth in Arabidopsis

43 citations , September 2014 in “Molecular Plant”

CLE40 and CRN/CLV2 pathways have opposite effects on root growth in Arabidopsis.

research Canonical WNT signaling promotes mammary placode development and is essential for initiation of mammary gland morphogenesis

293 citations , September 2004 in “Development”

WNT signaling is crucial for starting mammary gland development.

research Insights into male androgenetic alopecia using comparative transcriptome profiling: hypoxia-inducible factor-1 and Wnt/β-catenin signalling pathways

1 citations , July 2022 in “British Journal of Dermatology”

Targeting specific genes in certain pathways may help treat male pattern baldness.

research A Wnt5a-Cdc42 axis controls aging and rejuvenation of hair-follicle stem cells

5 citations , October 2020 in “bioRxiv (Cold Spring Harbor Laboratory)”

Aging hair follicle stem cells can be rejuvenated by inhibiting Cdc42.

research Defining BMP functions in the hair follicle by conditional ablation of BMP receptor IA

250 citations , November 2003 in “The Journal of Cell Biology”

BMP receptor IA is essential for proper hair cell differentiation in mice.

research ACE2 Inhibits Dermal Regeneration Through Ang II in Tissue Expansion

1 citations , January 2025 in “Journal of Cosmetic Dermatology”

Inhibiting ACE2 improves skin regeneration during tissue expansion.

research Faculty Opinions recommendation of Competitive balance of intrabulge BMP/Wnt signaling reveals a robust gene network ruling stem cell homeostasis and cyclic activation.

May 2013 in “Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature”

A balance between BMP and Wnt signals is crucial for hair follicle stem cell function and hair growth.

research Transcriptome analysis to identify the downstream genes of androgen receptor in dermal papilla cells

1 citations , January 2022 in “BMC Genomic Data”

The study found that androgen receptors in skin cells mainly affect the focal adhesion pathway and control the caveolin-1 gene, with implications for new treatments for related diseases.

research An inductive signalling network regulates mammalian tooth morphogenesis with implications for tooth regeneration

27 citations , August 2013 in “Cell Proliferation”

Understanding tooth development pathways may help regenerate teeth and treat dental issues.

research Activation of β-catenin signaling programs embryonic epidermis to hair follicle fate

193 citations , May 2008 in “Development”

Activating β-catenin can turn skin cells into hair follicles.

research Wnt/β-catenin signaling pathway activates melanocyte stem cells in vitro and in vivo

45 citations , April 2016 in “Journal of Dermatological Science”

The Wnt/β-catenin pathway can activate melanocyte stem cells and may help regenerate hair follicles.

Adult Epidermal Notch Activity Induces Dermal Accumulation of T Cells and Neural Crest Derivatives Through Upregulation of Jagged 1

research Adult epidermal Notch activity induces dermal accumulation of T cells and neural crest derivatives through upregulation of jagged 1

34 citations , November 2010 in “Development”

Activating Notch in adult skin causes T cells and neural crest cells to gather, leading to skin issues.

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