29 citations
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March 2010 in “Journal of Endocrinological Investigation” Lipocalin-2 levels are higher in women with PCOS and may indicate insulin resistance.
21 citations
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July 2016 in “Gynecological Endocrinology” Obese and non-obese women with PCOS have higher heart risk markers, especially if they are obese.
Fetuin-A levels are higher in PCOS patients, suggesting it may play a role in the condition.
1 citations
,
October 2014 in “Skin Pharmacology and Physiology” People with alopecia areata have higher levels of osteopontin, which might be important in the disease's development, but this doesn't relate to how severe the disease is.
4 citations
,
May 2023 in “Cells” Baricitinib and its combination with lonafarnib improve fat cell formation in certain genetic disorders.
The conclusion is that there's a link between high testosterone levels, insulin resistance, and certain skin conditions, regardless of obesity.
4 citations
,
January 2007 in “Gynecological endocrinology” Low leptin levels in obese women with high testosterone may indicate a tumor that secretes male hormones.
October 2023 in “Benha Journal of Applied Sciences” Men with male pattern baldness have lower levels of the antioxidant PON1.
2 citations
,
September 2002 in “Journal of Endocrinological Investigation” The GH-IGF-I axis is likely involved in the hormonal imbalances seen in non-obese women with functional hyperandrogenism.
February 2022 in “International journal of reproduction, contraception, obstetrics and gynecology” Acanthosis nigricans in teenage girls with PCOS is a sign of obesity, not insulin resistance or glucose intolerance.
6 citations
,
January 2018 in “Dermato-endocrinology” Darkened knuckles can be an early sign of insulin resistance.
January 2024 in “International Journal of Dermatology Venereology and Leprosy Sciences” Patients with acne vulgaris have lower serum irisin levels.
29 citations
,
January 2020 in “BioMed Research International” Sinapic acid may help fight obesity and promote hair growth.
March 2022 in “Benha Journal of Applied Sciences” AGA patients have lower serum vaspin levels, which might help detect the condition early.
November 2021 in “International Journal of Trichology” Low PON1 levels may indicate and predict the severity of hair loss.
13 citations
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August 2021 in “Frontiers in Bioengineering and Biotechnology” Exosomes from fat stem cells can reduce fat cell formation.
9 citations
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October 2014 in “Experimental and Clinical Endocrinology & Diabetes” Knuckle Acanthosis Nigricans is common in Latin American youth and may indicate early insulin resistance, especially in those with normal weight.
2 citations
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January 2021 in “The Scientific Journal of Al-Azhar Medical Faculty Girls” Alopecia areata patients have higher osteopontin levels and more eye changes, but their vision remains unaffected.
2 citations
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June 2024 in “Journal of the Pakistan Medical Association” Higher SFRP-4 levels were found in people without a diabetic family history.
February 2025 in “Clinical Cosmetic and Investigational Dermatology” Higher fasting insulin levels increase the risk of androgenetic alopecia.
September 2008 in “Fertility and Sterility” Exposure to fatty acids significantly increased androgen levels in female dogs, suggesting a link to conditions like insulin resistance and PCOS.
37 citations
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June 1996 in “Journal of cellular physiology” Retinoic acid, glucocorticoids, and IGF1 increase IGFBP-3 production in human dermal papilla cells, affecting hair growth.
7 citations
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February 2018 in “Journal of Investigative Dermatology” Fat tissue and a specific protein are crucial for healthy hair growth and maintenance.
January 2026 in “International Journal of Dermatology Venereology and Leprosy Sciences” Metformin may improve acanthosis nigricans by reducing insulin resistance.
April 2019 in “Journal of Investigative Dermatology” Removing REDD1 in mice increases skin fat by making fat cells larger and more numerous.
April 2018 in “Journal of Investigative Dermatology” People with alopecia areata have higher levels of a heart disease marker in their blood.
7 citations
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April 1992 in “Journal of steroid biochemistry and molecular biology/The Journal of steroid biochemistry and molecular biology” Women with non-classical congenital adrenal hyperplasia have higher levels of certain steroids, which can be reduced by treatment.
13 citations
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June 2015 in “International Journal of Dermatology” Non-obese women with hair loss have higher heart disease risk.
29 citations
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January 2009 in “Gynecological Endocrinology” Women with PCOS have higher levels of certain blood clotting factors, suggesting a greater risk of cardiovascular issues.
January 2023 in “ALEXMED ePosters (Online)” Alopecia patients have a higher risk of heart disease.