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research Transgenic Kallikrein 14 Mice Display Major Hair Shaft Defects Associated with Desmoglein 3 and 4 Degradation, Abnormal Epidermal Differentiation, and IL-36 Signature

15 citations , June 2020 in “The journal of investigative dermatology/Journal of investigative dermatology”

Mice with extra human KLK14 had hair and skin problems, including weaker cell bonds and inflammation, linked to Netherton syndrome.

research ICP5249 Promotes Hair Growth by Activating the AMPK-Autophagy Signaling Pathway

5 citations , July 2024 in “Journal of Microbiology and Biotechnology”

ICP5249 helps hair grow by activating a specific cell pathway.

research Bidirectional binding property of high glycine–tyrosine keratin-associated protein contributes to the mechanical strength and shape of hair

46 citations , June 2013 in “Journal of structural biology”

High glycine–tyrosine keratin-associated proteins help make hair strong and maintain its shape.

research Keratinocyte integrin α3β1 induces expression of the macrophage stimulating factor, CSF-1, through a YAP/TEAD-dependent mechanism.

8 citations , February 2024 in “Matrix Biology”

research Author response: Intercellular propagation of extracellular signal-regulated kinase activation revealed by in vivo imaging of mouse skin

1 citations , January 2015

ERK activation spreads between cells, influencing cell division and wound healing.

research The epidermal growth factor receptor decreases Stathmin 1 and triggers catagen entry in the mouse

10 citations , December 2015 in “Experimental dermatology”

EGFR helps mouse hair follicles stop growing by reducing certain growth regulators.

research Bone morphogenetic protein-2 (BMP-2) transactivates Dlx3 through Smad1 and Smad4: alternative mode for Dlx3 induction in mouse keratinocytes

79 citations , January 2002 in “Nucleic Acids Research”

BMP-2 activates the Dlx3 gene in mouse skin cells, important for hair and skin development.

research Constitutive activation of Stat3 in mouse epidermis is linked to hair deficiency and cytoskeletal network damage

1 citations , May 2015 in “Experimental Dermatology”

Overactive Stat3 in mouse skin causes hair loss and cell structure damage.

research Constitutive Stat3 activation alters behavior of hair follicle stem and progenitor cell populations

23 citations , September 2013 in “Molecular Carcinogenesis”

Increased Stat3 activity reduces hair follicle stem cells and boosts other stem/progenitor cells.

research DKK3–CKAP4 signaling drives fibroimmune remodeling and hair follicle miniaturization in androgenetic alopecia

May 2026 in “Theranostics”

The study explores the DKK3–CKAP4 signaling axis in androgenetic alopecia (AGA), focusing on its role in hair follicle miniaturization and fibroimmune remodeling. Researchers found that DKK3, expressed in hair follicles, acts as a negative regulator of hair growth, with recombinant DKK3 suppressing hair regrowth in both mouse and human models. Neutralizing DKK3 or CKAP4 restored hair growth and reversed androgen-induced fibroimmune changes, suggesting potential therapeutic benefits. The study highlights that targeting the DKK3–CKAP4 axis could mitigate hair loss in AGA by reversing pathological changes without affecting DKK1-mediated Wnt regulation, offering a novel therapeutic strategy.

research Constitutive Internalization of the Leucine-rich G Protein-coupled Receptor-5 (LGR5) to the Trans-Golgi Network

58 citations , February 2013 in “Journal of Biological Chemistry”

LGR5 mainly stays inside cells, moving to the trans-Golgi network, and this process is important for its role in cell signaling.

research 486 Molecular Mechanisms of Type II Spiral Ganglion Neuron Development

April 2023 in “Journal of clinical and translational science”

research The Mixed Lineage Kinase Leucine-Zipper Protein Kinase Exhibits a Differentiation-Associated Localization in Normal Human Skin and Induces Keratinocyte Differentiation upon Overexpression

17 citations , November 2000 in “Journal of Investigative Dermatology”

ZPK helps skin cells mature and may affect skin health.

research Type II Keratins Are Phosphorylated on a Unique Motif during Stress and Mitosis in Tissues and Cultured Cells

80 citations , June 2002 in “Molecular Biology of the Cell”

Type II keratins are uniquely phosphorylated during stress and mitosis, affecting their structure and function.

research In‐silico Screening of ATP‐competitive Inhibitory Activities of Phytochemicals against Janus Kinase 3 and Its In‐vitro Evaluation

April 2020 in “The FASEB journal”

Poncirin is a promising inhibitor of Janus Kinase 3, potentially better than tofacitinib.

research Synaptic processes and immune-related pathways implicated in Tourette syndrome

29 citations , January 2021 in “Translational Psychiatry”

The research suggests that Tourette syndrome is linked to both brain signaling and immune system pathways.

research Image1.TIF

December 2021

GPC1 is important for blood vessel growth in hair follicles and could help treat hair loss.

research Glutamic acid promotes hair growth in mice

12 citations , July 2021 in “Scientific Reports”

Glutamic acid helps increase hair growth in mice.

research Retardation of Hair Follicle Development by the Deletion of TrkC, High-Affinity Neurotrophin-3 Receptor

14 citations , September 1999 in “Journal of Investigative Dermatology”

Lack of TrkC receptor delays hair follicle development.

Demethylation of ITGAV Accelerates Osteogenic Differentiation in a Blast-Induced Heterotopic Ossification In Vitro Cell Culture Model

research Demethylation of ITGAV accelerates osteogenic differentiation in a blast-induced heterotopic ossification in vitro cell culture model

11 citations , December 2018 in “Bone”

Removing a methyl group from the ITGAV gene speeds up bone formation in a specific type of bone disease model.

research Selective Modulation of Hedgehog/GLI Target Gene Expression by Epidermal Growth Factor Signaling in Human Keratinocytes

226 citations , August 2006 in “Molecular and Cellular Biology”

EGF signaling affects gene expression in skin cells, influencing hair growth and potentially cancer.

research Ku80 as a Novel Receptor for Thymosin β4 That Mediates Its Intracellular Activity Different from G-actin Sequestering

37 citations , November 2007 in “Journal of Biological Chemistry”

Ku80 is a key receptor for Thymosin β4, affecting cell migration and wound healing.

research Protein Kinase Cε, which Sensitizes Skin to Sun's UV Radiation–Induced Cutaneous Damage and Development of Squamous Cell Carcinomas, Associates with Stat3

76 citations , February 2007 in “Cancer Research”

Protein Kinase Cε increases skin sensitivity to UV damage and skin cancer risk.

research Abstracts

7 citations , March 2023 in “Lasers in Surgery and Medicine”

Ablative fractional laser treatment nearly matches the gene reduction effects of topical vismodegib in skin cancer.

research 880 Gasdermin A3-mediated cell death causes niche collapse and precocious activation of hair follicle stem cells

2 citations , April 2019 in “Journal of Investigative Dermatology”

Gasdermin A3 causes hair follicle stem cells to activate too early, leading to hair loss.

research Isoginkgetin, a natural biflavonoid from Ginkgo biloba, inhibits inflammatory response in endothelial cells via suppressing NF-κB activation

2 citations , July 2025 in “Acta Pharmacologica Sinica”

Isoginkgetin reduces inflammation in cells by blocking NF-κB activation.

[4-t-Butylphenyl]-N-(4-imidazol-1-yl phenyl)sulfonamide (ISCK03) Inhibits SCF/c-kit Signaling in 501mel Human Melanoma Cells and Abolishes Melanin Production in Mice and Brownish Guinea Pigs

research [4-t-Butylphenyl]-N-(4-imidazol-1-yl phenyl)sulfonamide (ISCK03) inhibits SCF/c-kit signaling in 501mel human melanoma cells and abolishes melanin production in mice and brownish guinea pigs

26 citations , July 2007 in “Biochemical Pharmacology”

ISCK03 stops melanin production in human melanoma cells and lightens skin color in mice and guinea pigs.

Protein Kinase Akt2/PKBβ Is Involved in Blastomere Proliferation of Preimplantation Mouse Embryos

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