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GlossaryAKT signaling pathway

regulates cell growth, survival, and metabolism

The AKT signaling pathway, also known as the Protein Kinase B (PKB) pathway, is a crucial cell signaling system that regulates various cellular processes, including growth, survival, and metabolism. It is activated by growth factors and other extracellular signals, leading to the phosphorylation and activation of AKT, which then influences numerous downstream targets to promote cell proliferation and inhibit apoptosis (cell death). This pathway is significant in many physiological contexts and is often implicated in cancer and other diseases due to its role in cell survival and growth.

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research Epidermal Growth Factor Induces Proliferation of Hair Follicle-Derived Mesenchymal Stem Cells Through Epidermal Growth Factor Receptor-Mediated Activation of ERK and AKT Signaling Pathways Associated with Upregulation of Cyclin D1 and Downregulation of p16

83 citations , October 2016 in “Stem Cells and Development”

Epidermal growth factor helps hair stem cells grow by activating specific cell pathways.

research Monoterpenoid Loliolide Regulates Hair Follicle Inductivity of Human Dermal Papilla Cells by Activating the Akt/ ¥-Catenin Signaling Pathway

37 citations , November 2019 in “Journal of Microbiology and Biotechnology”

Loliolide can boost hair growth by activating specific cell pathways.

research Interaction of the AKT and β-catenin signalling pathways and the influence of photobiomodulation on cellular signalling proteins in diabetic wound healing

19 citations , September 2023 in “Journal of Biomedical Science”

Photobiomodulation may help heal diabetic wounds, but more research is needed.

Lactoferrin Promotes Hair Growth in Mice and Increases Dermal Papilla Cell Proliferation Through Erk/Akt and Wnt Signaling Pathways

research Lactoferrin promotes hair growth in mice and increases dermal papilla cell proliferation through Erk/Akt and Wnt signaling pathways

18 citations , April 2019 in “Archives of Dermatological Research”

Lactoferrin helps mice grow hair by increasing cell growth and hair follicle development.

Bacillus/Trapa Japonica Fruit Extract Ferment Filtrate Enhances Human Hair Follicle Dermal Papilla Cell Proliferation via the Akt/ERK/GSK-3β Signaling Pathway

research Bacillus/Trapa japonica Fruit Extract Ferment Filtrate enhances human hair follicle dermal papilla cell proliferation via the Akt/ERK/GSK-3β signaling pathway

10 citations , May 2019 in “BMC Complementary and Alternative Medicine”

The extract from Bacillus/Trapa japonica fruit helps increase hair growth and could be a potential treatment for hair loss.

Extremely Low-Frequency Electromagnetic Fields Increase the Expression of Anagen-Related Molecules in Human Dermal Papilla Cells via GSK-3β/ERK/Akt Signaling Pathway

research Extremely Low-Frequency Electromagnetic Fields Increase the Expression of Anagen-Related Molecules in Human Dermal Papilla Cells via GSK-3β/ERK/Akt Signaling Pathway

7 citations , January 2020 in “International Journal of Molecular Sciences”

Low-frequency electromagnetic fields can boost molecules related to hair growth in human skin cells.

Ginsenoside Rg4 Enhances the Inductive Effects of Human Dermal Papilla Spheres on Hair Growth Via the AKT/GSK-3β/β-Catenin Signaling Pathway

research Ginsenoside Rg4 Enhances the Inductive Effects of Human Dermal Papilla Spheres on Hair Growth Via the AKT/GSK-3β/β-Catenin Signaling Pathway

4 citations , June 2021 in “Journal of Microbiology and Biotechnology”

Ginsenoside Rg4 from ginseng may help hair growth by activating certain cell signals.

research TAZ enhances the activity of the AKT signaling pathway to promote adipogenesis of gADSCs

September 2025 in “Stem Cell Research & Therapy”

TAZ boosts fat cell formation in goat stem cells by activating a specific signaling pathway.

Effect of Scenedesmus Deserticola JD052 Extracts on Hair Inductivity by Regulating the AKT and GSK3β/β-Catenin Signaling Pathways in Human Dermal Papilla Cells

research Effect of Scenedesmus deserticola JD052 Extracts on Hair Inductivity by Regulating the AKT and GSK3β/β-Catenin Signaling Pathways in Human Dermal Papilla Cells

February 2025 in “Applied Sciences”

Scenedesmus deserticola JD052 extracts may help hair growth and could be a natural treatment for hair loss.

Peer Review of Melatonin Increases Growth Properties in Human Dermal Papilla Spheroids by Activating AKT/GSK3β/β-Catenin Signaling Pathway

research Peer Review #2 of "Melatonin increases growth properties in human dermal papilla spheroids by activating AKT/GSK3β/β-Catenin signaling pathway (v0.2)"

May 2022

Melatonin improves hair growth-related cell properties by activating a certain cell signaling pathway.

research Peer Review #2 of "Melatonin increases growth properties in human dermal papilla spheroids by activating AKT/GSK3β/β-Catenin signaling pathway (v0.1)"

May 2022

Melatonin may improve hair growth by affecting certain cell signaling pathways.

research Peer Review #1 of "Melatonin increases growth properties in human dermal papilla spheroids by activating AKT/GSK3β/β-Catenin signaling pathway (v0.1)"

May 2022

Melatonin may help hair growth by affecting certain cell signals, and the paper improved after revisions.

Bioactive Small Molecule Enhances Skin Burn Wound Healing and Hair Follicle Regeneration by Activating PI3K/AKT Signaling Pathway: A Preclinical Evaluation in Animal Model

research Bioactive Small Molecule Enhances Skin Burn Wound Healing and Hair Follicle Regeneration by Activating PI3K/AKT Signaling Pathway: A Preclinical Evaluation in Animal Model

February 2022 in “Journal of Biomedical Nanotechnology”

Shikonin, a small molecule, speeds up burn wound healing and hair growth by activating the PI3K/Akt pathway.

research Exercise activates the PI3K-AKT signal pathway by decreasing the expression of 5α-reductase type 1 in PCOS rats

28 citations , May 2018 in “Scientific reports”

Exercise improves insulin sensitivity and hormone regulation in PCOS rats.

research Pyridoxine regulates hair follicle development via the PI3K/Akt, Wnt and Notch signalling pathways in rex rabbits

10 citations , October 2021 in “Animal nutrition”

Vitamin B6 helps increase hair growth and density in rabbits by affecting certain cell signaling pathways.

research Effects of the PI3K/Akt signaling pathway on the hair inductivity of human dermal papilla cells in hair beads

12 citations , April 2022 in “Journal of Bioscience and Bioengineering”

Activating the PI3K/Akt pathway improves hair growth by human dermal papilla cells in hair beads.

research Melatonin increases growth properties in human dermal papilla spheroids by activating AKT/GSK3β/β-Catenin signaling pathway

4 citations , May 2022 in “PeerJ”

Melatonin may help hair growth by affecting cell growth and hair-related signaling pathways.

research Cepharanthine Suppresses Herpes Simplex Virus Type 1 Replication Through the Downregulation of the PI3K/Akt and p38 MAPK Signaling Pathways

30 citations , December 2021 in “Frontiers in Microbiology”

Cepharanthine effectively reduces Herpes Simplex Virus Type 1 by blocking certain cell pathways and promoting cell death.

research Bioassay-guided isolation of two antiproliferative metabolites from Pterocarpus indicus Willd. against TGF-β-induced prostate stromal cells (WPMY-1) proliferation via PI3K/AKT signaling pathway

3 citations , October 2024 in “Frontiers in Pharmacology”

Compounds from Pterocarpus indicus may help treat benign prostatic hyperplasia by stopping cell growth.

research Vitamin B6 promotes the activation of primordial follicles through the PI3K/Akt signaling pathway

December 2025 in “Journal of Ovarian Research”

Vitamin B6 may help activate dormant follicles.

Therapeutic Potential of Isoproterenol in Androgenetic Alopecia: Activation of Hair Follicle Stem Cells via the PI3K/AKT/β-Catenin Signaling Pathway

research Therapeutic potential of isoproterenol in androgenetic alopecia: activation of hair follicle stem cells via the PI3K/AKT/β-Catenin signaling pathway

June 2025 in “Stem Cell Research & Therapy”

Isoproterenol may help treat hair loss by activating hair follicle stem cells.

research Reductive Stress Selectively Disrupts Collagen Homeostasis and Modifies Growth Factor-independent Signaling Through the MAPK/Akt Pathway in Human Dermal Fibroblasts

9 citations , March 2019 in “Molecular & cellular proteomics”

Reductive stress messes up collagen balance and alters cell signaling in human skin cells, which could help treat certain skin diseases.

research Water extract of cacumen platycladi promotes hair growth through the Akt/GSK3β/β-catenin signaling pathway

February 2023 in “Frontiers in Pharmacology”

Water extract of Cacumen Platycladi helps hair growth by activating specific cell pathways.

research Corrigendum: Water extract of cacumen platycladi promotes hair growth through the Akt/GSK3β/β-catenin signaling pathway

May 2023 in “Frontiers in Pharmacology”

Water extract of cacumen platycladi helps hair growth by affecting specific cell pathways.

research Ginsenoside Rb1 promotes the growth of mink hair follicle via PI3K/AKT/GSK-3β signaling pathway

28 citations , May 2019 in “Life Sciences”

Ginsenoside Rb1 from Panax ginseng helps mink hair grow by activating certain cell signals.

research The PI3K-Akt-mTOR and Associated Signaling Pathways as Molecular Drivers of Immune-Mediated Inflammatory Skin Diseases: Update on Therapeutic Strategy Using Natural and Synthetic Compounds

9 citations , June 2023 in “Cells”

Certain natural and synthetic compounds may help treat inflammatory skin diseases by targeting a specific signaling pathway.

Stimulation by Exosomes from Hypoxia-Preconditioned Hair Follicle Mesenchymal Stem Cells Facilitates Mitophagy by Inhibiting the PI3K/AKT/mTOR Signaling Pathway to Alleviate Ulcerative Colitis

research Stimulation by exosomes from hypoxia-preconditioned hair follicle mesenchymal stem cells facilitates mitophagy by inhibiting the PI3K/AKT/mTOR signaling pathway to alleviate ulcerative colitis

January 2024 in “Theranostics”

Exosomes from special stem cells help treat ulcerative colitis by reducing inflammation and stress.

research Vanillic Acid Stimulates Anagen Signaling via the PI3K/Akt/ β-Catenin Pathway in Dermal Papilla Cells

14 citations , May 2020 in “Biomolecules & Therapeutics”

Vanillic acid from wheat bran may promote hair growth by activating certain cell pathways and reversing hormone-related hair loss.

The Extract of Periplaneta Americana Promotes Hair Regrowth in Mice with Alopecia by Regulating the FOXO/PI3K/AKT Signaling Pathway and Skin Microbiota

research The Extract of Periplaneta americana (L.) Promotes Hair Regrowth in Mice with Alopecia by Regulating the FOXO/PI3K/AKT Signaling Pathway and Skin Microbiota

August 2025 in “Current Issues in Molecular Biology”

Periplaneta americana extract helps hair regrowth in mice with alopecia.

PBX Homeobox 1 Enhances Hair Follicle Mesenchymal Stem Cell Proliferation and Reprogramming Through Activation of the AKT/Glycogen Synthase Kinase Signaling Pathway and Suppression of Apoptosis

research PBX homeobox 1 enhances hair follicle mesenchymal stem cell proliferation and reprogramming through activation of the AKT/glycogen synthase kinase signaling pathway and suppression of apoptosis

26 citations , August 2019 in “Stem Cell Research & Therapy”

PBX1 helps hair stem cells grow and change by turning on certain cell signals and preventing cell death, which may be useful for hair regrowth treatments.