July 2023 in “Stem Cells Translational Medicine” Mesenchymal Stem/Stromal Cells (MSCs) help in wound healing and tissue regeneration, but can also contribute to tumor growth. They show promise in treating chronic wounds and certain burns, but their full healing mechanisms and potential challenges need further exploration.
31 citations
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August 2015 in “Stem Cells Translational Medicine” Human skin can provide stem cells for tissue repair and regeneration, but there are challenges in obtaining and growing these cells safely.
17 citations
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May 2014 in “Cell transplantation” Genetically modified stem cells from human hair follicles can lower blood sugar and increase survival in diabetic mice.
13 citations
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March 2024 in “Cell Transplantation” Engineered skin tissue is a promising tool for safer cosmetic testing.
October 2025 in “Cell Transplantation” New hair loss treatments like stem cells and gene therapy show promise but need more research for safety and effectiveness.
33 citations
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January 2018 in “Blood” Ruxolitinib helps protect skin stem cells and keeps skin healthy in mice with skin GVHD.
July 2014 in “European Journal of Cancer” p14ARF and p16Ink4a cause hair follicle stem cell aging and dysfunction.
2 citations
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March 2021 in “Cutis” Some breast cancer treatments, like taxanes, can cause long-term hair loss.
99 citations
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April 1998 in “The journal of investigative dermatology/Journal of investigative dermatology” Hair follicles help skin immune recovery after UVB exposure.
54 citations
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July 1994 in “Journal of Dermatological Science” FK506 may stimulate hair growth when applied to the skin.
45 citations
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June 2018 in “Frontiers in immunology” MDSC-Exo can treat autoimmune alopecia areata and promote hair regrowth in mice.
9 citations
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January 2018 in “International Journal of Trichology” A woman's hair loss from graft versus host disease helps understand similar hair loss conditions.
1 citations
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May 2024 in “Journal of Dermatological Science” The study explores the use of keratinocyte-like cells derived from human adipose-derived mesenchymal stromal cells (KC-AD-MSCs) to treat Recessive Dystrophic Epidermolysis Bullosa (RDEB) in mice. By injecting these cells into the skin, researchers observed the deposition of type VII collagen at the dermal-epidermal junction, which is essential for skin integrity. This treatment reduced blister formation and improved skin structure, indicating that KC-AD-MSCs could potentially correct collagen insufficiency and repair anchoring fibrils in RDEB. Although the number of anchoring fibrils was not fully restored, it was adequate to maintain function. The study suggests KC-AD-MSCs as a promising treatment for RDEB, but further research is needed to refine cell dosage and administration.
83 citations
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May 2022 in “Journal of Advanced Research” Enhancing glycolysis in mesenchymal stromal/stem cells boosts their immune functions and therapy potential.
13 citations
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October 2021 in “International Journal of Molecular Sciences” The HATMSC1 cell line from fat tissue can produce helpful factors for regenerative and immune therapies.
August 1993 in “Journal of Dermatological Science” Cyclosporin and minoxidil promote hair growth.
49 citations
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March 2014 in “Journal of Investigative Dermatology” Using the drugs AMD3100 and Tacrolimus together greatly improves skin healing and hair growth after a deep skin cut by increasing stem cells in the wound.
116 citations
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April 2020 in “Stem Cell Research & Therapy” Wharton's jelly stem cells show diverse traits and functions.
44 citations
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April 2023 in “Genes & Diseases” Mesenchymal stem cells release substances that help tissue repair, and their effectiveness can be improved by understanding environmental influences.
15 citations
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November 2017 in “JAAD Case Reports” Brentuximab may cause hair to regain color.
13 citations
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August 2024 in “iScience” 3D spheroid culture makes stem cells better at reducing inflammation.
12 citations
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February 2023 in “Stem Cell Research & Therapy” HGF-modified hair follicle stem cells help brain recovery after injury in rats.
1036 citations
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August 2019 in “Cells” Mesenchymal stem cells can help repair body tissues with low risk of rejection.
169 citations
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February 2018 in “Immunity” Inactive stem cells in hair follicles and muscles can avoid detection by the immune system.
90 citations
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May 2019 in “Drugs” Long-term use of azole antifungals can cause hair loss, hormonal imbalances, and severe skin reactions.
August 2024 in “Frontiers in Pharmacology” Cyclosporine may cause hair loss, so patients need monitoring.
294 citations
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January 2016 in “Stem Cells International” Adipose-derived stem cells are promising for tissue and organ repair due to their easy access and versatility.
5 citations
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November 2025 in “Cells” Advancements in wound healing aim to improve personalized treatments and enhance healing outcomes.
4 citations
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May 2025 in “Stem Cell Research & Therapy” Extracellular vesicles may help prevent and repair spine disc degeneration.
3 citations
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May 2025 in “Stem Cell Research & Therapy” This study explores the use of human umbilical cord mesenchymal stem cells (hUC-MSCs) and their conditioned medium (hUC-MSC-CM) for treating atopic dermatitis (AD) in mouse models. Both treatments significantly alleviate AD-like symptoms, such as erythema and epidermal thickening, by inhibiting neutrophil chemotaxis and regulating chemokine expression through the STAT3 signaling pathway. The hUC-MSC-CM offers a promising cell-free alternative to whole-cell therapy, suggesting a new strategy for AD treatment. The study supports further research and potential clinical trials for using hUC-MSCs in managing moderate-to-severe AD.