research Identification of Established Drugs for Contemporary Indications: A Hospital Based Study
Drug repurposing can be cost-effective but needs more testing for safety and effectiveness.
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420-450 / 1000+ results research Drug–Drug Coamorphous System of Tadalafil and Finasteride for Enhanced Pharmaceutical Performance
Combining tadalafil and finasteride improves their solubility and effectiveness.
research Monocyclic Aromatic Compounds
Monocyclic aromatic compounds are important for developing various drugs and treatments.
research Template‐directed self‐assembly and growth of insulin amyloid fibrils
A new method speeds up insulin amyloid fibril growth, useful for studying diseases.
research Modulation of neuropeptide Y and Y1 receptor expression in the amygdala by fluctuations in the brain content of neuroactive steroids during ethanol drinking discontinuation in Y1R/LacZ transgenic mice
Stopping alcohol after long-term use causes anxiety and changes brain chemicals.
research In vivo evidence for an increase in 5alpha‐reductase activity in the rat central nervous system following morphine exposure
Morphine increases testosterone breakdown in the rat brain and spinal cord.
research In Vitroandin VivoStructure-Activity Relationships of Novel Androgen Receptor Ligands with Multiple Substituents in the B-Ring
Certain changes to the B-ring of androgen receptor ligands can increase their effectiveness for potential treatments of muscle and bone conditions.
research Double Dosing
Taking the same medication under different brand names caused harmful side effects.
research The Use of Anabolic Steroids by Bodybuilders in the State of Sergipe, Brazil
Many bodybuilders in Sergipe, Brazil use anabolic steroids, facing health risks like acne, irritability, and hypertension.
research Activated Polyamine Catabolism Depletes Acetyl-CoA Pools and Suppresses Prostate Tumor Growth in TRAMP Mice
Overexpressing SSAT enzyme reduces prostate tumor growth in mice.
research Developmental Toxicity of Levo-Alpha-Acetylmethadol (LAAM) in Tolerant Rats
LAAM caused developmental toxicity in tolerant rats without causing birth defects.
research Recent progress of polymeric microneedle-assisted long-acting transdermal drug delivery
Polymeric microneedles offer a less invasive, long-lasting drug delivery method that improves patient compliance and reduces side effects.
research BIO-ANALYTICAL METHOD DEVELOPMENT AND VALIDATION OF FINASTERIDE, TADALAFIL, AND ITS APPLICATION TO PHARMACOKINETIC STUDIES IN RAT PLASMA BY USING LC-MS/MS
A reliable method was developed to measure Finasteride and Tadalafil in rat blood.
research Neurotoxins Acting at Synaptic Sites: A Brief Review on Mechanisms and Clinical Applications
Neurotoxins can affect neurotransmitter release and have potential in treating muscle, pain, and cancer conditions, but more research is needed on how they work.
research Polymorphism
Different crystal forms of drugs can change their effectiveness.
research A Randomized Double-Blind Placebo-Controlled Pilot Trial on the Effects of Testosterone Undecanoate Plus Dutasteride or Placebo on Muscle Strength, Body Composition, and Metabolic Profile in Transmen
Testosterone with dutasteride improves muscle strength and body composition in trans men.
research Locally Synthetized 17-β-Estradiol Reverses Amyloid-β-42-Induced Hippocampal Long-Term Potentiation Deficits
A brain-made hormone can protect against memory-related brain damage caused by harmful proteins.
research Erythematous cutaneous nodules caused by adulterated cocaine
Talc in street cocaine can cause immune-reactive skin nodules where injected.
research Increased levels of prostaglandin-like material in the canine blood during arterial hypotension produced by hydralazine, dihydralazine and minoxidil
These drugs raise prostaglandin-like material in dog blood, possibly causing blood vessel widening.
research Miscellaneous Steroids
The document concludes that scientists created various steroids with different properties, including a more effective semi-synthetic vitamin D.
research Androgen receptor modulators: a review of recent patents and reports (2012-2018)
New androgen receptor modulators show promise for treating diseases like prostate cancer and muscle wasting.
research Relating neurosteroid modulation of inhibitory neurotransmission to behaviour
Neurosteroids can influence behavior by modulating brain inhibition, with potential for treating psychiatric disorders.
research Olanzapine counteracts stress-induced anxiety-like behavior in rats
Olanzapine reduces stress-related anxiety in rats when given acutely.
research Finasteride, a 5α-reductase inhibitor, potentiates antinociceptive effects of morphine, prevents the development of morphine tolerance and attenuates abstinence behavior in the rat
Finasteride boosts morphine's pain relief, stops tolerance, and reduces withdrawal in rats.
research Divergent neuroactive steroid responses to stress and ethanol in rat and mouse strains: relevance for human studies
Different rat and mouse strains respond differently to stress and alcohol, which may help us understand similar human mechanisms.
research State of the Art in Constructing Gas-Propelled Dissolving Microneedles for Significantly Enhanced Drug-Loading and Delivery Efficiency
Gas-propelled dissolving microneedles improve drug loading and delivery efficiency.
research Effect of Carbamates on mRNA Encoding Lipid Enzymes in Hamster Flank Organs
Carbamates may help treat androgen-dependent conditions by changing how certain lipid enzymes are produced.
research Ανάπτυξη καινοτόμων πεπτιδικών φορέων με ιδιότητες αυτοσυναρμογής για τοπική χορήγηση φαρμάκων
Self-assembling peptide hydrogels effectively deliver drugs locally, enhancing treatment and reducing side effects.
research 180 The Efficacy of Amoxapine for Ejaculatory Dysfunction
Amoxapine may be effective for treating ejaculatory dysfunction.
research Groundnut seed production manual.
Arsenic trioxide effectively treats APL, improving survival rates despite its toxicity.