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GlossaryAnagen Phase

active period of hair growth in the hair cycle

The Anagen Phase, also known as the growth phase, is the active period of hair growth in the hair cycle. During this phase, hair follicles are actively producing new hair cells, leading to the elongation of the hair shaft. This phase can last anywhere from 2 to 7 years, depending on genetic factors, and determines the maximum length of the hair.

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Adenosine Stimulates Growth of Dermal Papilla and Lengthens the Anagen Phase by Increasing the Cysteine Level via Fibroblast Growth Factors 2 and 7 in an Organ Culture of Mouse Vibrissae Hair Follicles

research Adenosine stimulates growth of dermal papilla and lengthens the anagen phase by increasing the cysteine level via fibroblast growth factors 2 and 7 in an organ culture of mouse vibrissae hair follicles

28 citations , October 2011 in “International Journal of Molecular Medicine”

Adenosine helps hair grow longer and stronger by boosting certain growth factors and signaling pathways.

research The mouse hairy ears mutation exhibits an extended growth (anagen) phase in hair follicles and altered Hoxc gene expression in the ears

10 citations , November 2008 in “Veterinary Dermatology”

The mouse hairy ears mutation causes longer ear hair due to changes in gene expression.

research Effect of Plantago asiatica L. extract on the anagen phase in human hair follicle dermal papilla cells

5 citations , March 2023 in “Journal of Cosmetic Dermatology”

Plantago asiatica L. extract can promote hair growth by enhancing the anagen phase.

research Leptin of dermal adipose tissue is differentially expressed during the hair cycle and contributes to adipocyte‐mediated growth inhibition of anagen‐phase vibrissa hair

30 citations , October 2014 in “Experimental Dermatology”

Leptin from skin fat can slow hair growth during certain phases.

A Spermidine-Based Nutritional Supplement Prolongs the Anagen Phase of Hair Follicles in Humans: A Randomized, Placebo-Controlled, Double-Blind Study

research A spermidine-based nutritional supplement prolongs the anagen phase of hair follicles in humans: a randomized, placebo-controlled, double-blind study

8 citations , October 2017 in “Dermatology practical & conceptual”

A spermidine-based supplement may help hair grow longer by keeping it in the growth phase.

research Effect of Escin in Human Hair Follicular Organ Culture: Prolonged Anagen Phase

January 2026 in “Chonnam Medical Journal”

Escin helps keep hair follicles in the growth phase longer.

research Exposure to gamma-rays at the telogen phase of the hair cycle inhibits hair follicle regeneration at the anagen phase in mice

6 citations , November 2013 in “International Journal of Radiation Biology”

Gamma-rays exposure during the resting phase of hair growth can damage hair regeneration and color in mice.

research ESDR586 - Interest of Silybum marianum extract, Manganese PCA and Lespedeza capitata extract in a new anti-hair loss serum to stimulate hair growth and prolong anagen phase

September 2022

The serum with these ingredients may help reduce hair loss and promote growth.

research Exposure to gamma-rays at the telogen phase of the hair cycle inhibits hair follicle regeneration at the anagen phase in mice

November 2013 in “Institutional Repositories DataBase (IRDB)”

Gamma-ray exposure during hair rest phase harms hair growth and color in mice.

18-β-Glycyrrhetinic Acid Promotes Hair Growth by Stimulating the Proliferation of Dermal Papilla Cells and Outer Root Sheath Cells, and Extends the Anagen Phase by Inhibiting 5α-Reductase

research 18-β-Glycyrrhetinic Acid Promotes Hair Growth by Stimulating the Proliferation of Dermal Papilla Cells and Outer Root Sheath Cells, and Extends the Anagen Phase by Inhibiting 5α-Reductase

July 2024 in “Biological and Pharmaceutical Bulletin”

Licorice extract helps hair growth and may treat hair loss.

research 1103 Derinat extends hair cycle at anagen phase by decreasing the level of TRPCs-mediated intracellular ROS accumulation in skin

April 2023 in “The journal of investigative dermatology/Journal of investigative dermatology”

Derinat helps extend hair growth by reducing harmful molecules in skin cells.

Interest of Silybum Marianum Extract, Manganese PCA, and Lespedeza Capitata Extract in a New Anti-Hair Loss Serum to Stimulate Hair Growth and Prolong Anagen Phase

research 586 Interest of Silybum marianum extract, Manganese PCA and Lespedeza capitata extract in a new anti-hair loss serum to stimulate hair growth and prolong anagen phase

November 2022 in “Journal of Investigative Dermatology”

The extract of Silybum marianum, Manganese PCA, and Lespedeza capitata can boost hair growth and extend the growth phase when combined in a serum.

research Histochemistry of the human hair follicle with consideration of anagen phases I to VI

18 citations , June 1992 in “Acta Histochemica”

Human hair follicles have a unique cell distribution and differentiation pattern during growth.

research PDGF isoforms induce and maintain anagen phase of murine hair follicles

136 citations , June 2006 in “Journal of Dermatological Science”

PDGF isoforms can promote and sustain hair growth.

Oral Spermidine Supplementation Prolongs Hair Follicle Anagen Phase with Sustained Effects: A Randomized, Double-Blind, Placebo-Controlled Trial

research Oral Spermidine Supplementation Prolongs Hair Follicle Anagen Phase with Sustained Effects: A Randomized, Double-Blind, Placebo-Controlled Trial

January 2025 in “MEDS Public Health and Preventive Medicine”

Spermidine supplements can help extend the hair growth phase and may be useful for treating hair loss.

research De Novo Production of Dermal Papilla Cells during the Anagen Phase of the Hair Cycle

41 citations , June 2010 in “Journal of Investigative Dermatology”

New cells are added to the hair's dermal papilla during the active growth phase.

Novel ALK5 Inhibitor TP0427736 Reduces TGF-β Induced Growth Inhibition in Human Outer Root Sheath Cells and Elongates Anagen Phase in Mouse Hair Follicles

research Novel ALK5 inhibitor TP0427736 reduces TGF-β induced growth inhibition in human outer root sheath cells and elongates anagen phase in mouse hair follicles

14 citations , January 2017 in “Pharmacological Reports”

TP0427736 may help treat hair loss by blocking a specific protein and promoting hair growth.

research Interleukin 6 induces the hair follicle growth phase (anagen)

12 citations , June 2006 in “Journal of Dermatological Science”

Interleukin 6 helps hair grow.

Scientific Opinion on the Substantiation of a Health Claim Related to Spermidine and Prolongation of the Growing Phase (Anagen) of the Hair Cycle Pursuant to Article 13(5) of Regulation (EC) No 1924/2006

research Scientific Opinion on the substantiation of a health claim related to spermidine and prolongation of the growing phase (anagen) of the hair cycle pursuant to Article 13(5) of Regulation (EC) No 1924/2006

1 citations , December 2011 in “EFSA Journal”

Spermidine may help extend the growth phase of hair.

research Hair growth-promoting effects of Stellera chamaejasme L. extract on C57BL/6 mice via induction of anagen phase genes

May 2025 in “Journal of Traditional Chinese Medical Sciences”

Stellera chamaejasme L. extract promotes hair growth by activating hair growth genes.

research Pilose antler extract promotes hair growth in androgenic alopecia mice by promoting the initial anagen phase

April 2024 in “Biomedicine & pharmacotherapy”

Pilose antler extract helps hair grow in mice with a type of hair loss by speeding up the growth phase.

CARI ONE Induces Anagen Phase of Telogenic Hair Follicles Through Regulation of β-Catenin, Stimulation of Dermal Papilla Cell Proliferation, and Melanogenesis

research CARI ONE Induces Anagen Phase of Telogenic Hair Follicles Through Regulation of β-Catenin, Stimulation of Dermal Papilla Cell Proliferation, and Melanogenesis

3 citations , April 2014 in “Journal of Dietary Supplements”

CARI ONE helps start hair growth and makes hair follicles bigger and more numerous.

research 575 An extract of Leontopodium alpinum prolongs anagen phase in human hair follicles ex vivo

April 2021 in “Journal of Investigative Dermatology”

Leontopodium alpinum extract may help reduce hair shedding by keeping hair in the growth phase longer.

Response to Comments on the Scientific Opinion on the Substantiation of a Health Claim Related to Spermidine and Prolongation of the Growing Phase (Anagen) of the Hair Cycle Pursuant to Article 13(5) of Regulation (EC) No 1924/2006

research Response to comments on the Scientific Opinion on the substantiation of a health claim related to spermidine and prolongation of the growing phase (anagen) of the hair cycle pursuant to Article 13(5) of Regulation (EC) No 1924/2006

July 2012 in “EFSA supporting publications”

The EFSA maintained its view that spermidine's effect on hair growth is related to disease treatment and does not meet the health claim criteria.

research Faculty Opinions recommendation of De novo production of dermal papilla cells during the anagen phase of the hair cycle.

December 2010 in “Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature”

New cells join the hair's dermal papilla during the growth phase, possibly affecting hair thickness.

research Epidermal growth factor induced apoptosis in the outer root sheath cells of anagen hair and changed the hair cycle to the catagen phase

September 2004 in “Kitasato medical journal”

Epidermal growth factor causes hair loss by triggering cell death and changing the hair cycle.

Pea Sprout Extract Promotes Hair Follicle Regeneration Via Anagen Phase Prolongation And Dual Modulation Of Oxidative And Inflammatory Signaling

research Pea Sprout Extract Promotes Hair Follicle Regeneration via Anagen Phase Prolongation and Dual Modulation of Oxidative and Inflammatory Signaling

November 2025 in “Journal of Microbiology and Biotechnology”

Pea sprout extract may help hair regrow by reducing stress and inflammation.

research Comparative Studies of the Diameters of Hairshafts in Anagen and in Telogen Phases in Male Adults Without Alopecia and in Male Adults With Androgenetic Alopecia

6 citations , January 1981

research A case of loose anagen hair syndrome associated with trichotillomania in a 14-year-old girl

May 2024 in “Cosmoderma”

A 14-year-old girl with a condition that makes her hair easy to pull out also has a hair-pulling disorder, and treatment helped but she relapsed after a year.

research Loose Anagen Hair Syndrome in a Saudi Girl

October 2021 in “Dermatology practical & conceptual”

A Saudi girl was diagnosed with Loose Anagen Hair Syndrome, a rare condition causing easy hair loss without scarring.