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GlossaryAnakinra

medication that inhibits interleukin-1 to reduce inflammation

Anakinra is a medication that blocks the activity of interleukin-1 (IL-1), a protein involved in inflammatory responses. It is commonly used to treat conditions like rheumatoid arthritis and certain types of autoinflammatory diseases by reducing inflammation and pain.

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research Successful rapid subcutaneous desensitization to anakinra in a case of delayed‐type hypersensitivity reaction

6 citations , February 2016 in “British Journal of Dermatology”

A woman with a drug allergy to anakinra was successfully desensitized, allowing her to continue treatment without allergic reactions.

research North American clinical management guidelines for hidradenitis suppurativa: A publication from the United States and Canadian Hidradenitis Suppurativa Foundations

256 citations , March 2019 in “Journal of the American Academy of Dermatology”

There is no standardized treatment for hidradenitis suppurativa, and individualized plans are needed.

research Skin toxicity caused by EGFR antagonists—An autoinflammatory condition triggered by deregulated IL‐1 signaling?

19 citations , September 2008 in “Journal of Cellular Physiology”

Blocking EGFR can cause skin inflammation by disrupting IL-1 signaling.

research Commonalities Between COVID-19 and Radiation Injury

18 citations , October 2020 in “Radiation Research”

Some drugs may help treat both COVID-19 and radiation injury.

research Erlotinib-Induced Skin Inflammation Is IL-1 Mediated in KC-Tie2 Mice and Human Skin Organ Culture

15 citations , October 2014 in “The journal of investigative dermatology/Journal of investigative dermatology”

Erlotinib causes skin inflammation through IL-1, which can be reduced by anakinra.

research Current systemic treatment strategies for hidradenitis suppurativa

1 citations , January 2017 in “Expert opinion on orphan drugs”

Adalimumab is the most effective treatment for severe hidradenitis suppurativa, but more research is needed to improve treatment options.

Inflammation in Androgenetic Alopecia and Hair Loss: Linking Neurosciences, Endocrinology, and Dermatology

research Inflammation in androgenetic alopecia and hair loss: linking neurosciences-endocrinology-dermatology

1 citations , May 2012 in “Hair transplant forum international”

Hair loss in men may be caused by inflammation triggered by hormones, and treatments reducing inflammation could potentially promote hair growth.

research Data from Tumor Necrosis Factor-α and Interleukin-1 Antagonists Alleviate Inflammatory Skin Changes Associated with Epidermal Growth Factor Receptor Antibody Therapy in Mice

March 2023

TNFα and interleukin-1 blockers reduce skin inflammation from EGFR antibody therapy.

research Data from Tumor Necrosis Factor-α and Interleukin-1 Antagonists Alleviate Inflammatory Skin Changes Associated with Epidermal Growth Factor Receptor Antibody Therapy in Mice

March 2023

TNFα and interleukin-1 blockers reduce skin inflammation from EGFR antibody therapy.

British Society for Pediatric Dermatology Annual Meeting, Sheffield, 18-19 November 2016

research British Society for Paediatric Dermatology Annual Meeting, Sheffield, 18-19 November 2016

December 2016 in “British Journal of Dermatology”

The meeting highlighted the importance of genetic testing and multidisciplinary approaches in pediatric dermatology.

research Adverse Effects and Drug Interactions of Biologic Agents

March 2010 in “Anti-inflammatory & anti-allergy agents in medicinal chemistry”

Biologic agents can be effective for rheumatic diseases but have risks like infections and require careful monitoring and patient information.

research Sudden improvement of alopecia universalis and psoriatic arthritis while receiving upadacitinib: a case-based review

5 citations , October 2024 in “Reumatismo”

Upadacitinib significantly improved alopecia universalis and psoriatic arthritis in a patient.

research Upadacitinib for management of alopecia areata and rheumatoid arthritis: Letter to the editor

April 2024 in “JEADV clinical practice”

Upadacitinib significantly improved both rheumatoid arthritis and alopecia areata in a patient.

research Upadacitinib Efficacy for the Treatment of Concomitant Psoriasis and Alopecia Areata

December 2023

Upadacitinib effectively treated a patient with multiple inflammatory conditions.

research JAK-inhibitors. New players in the field of immune-mediated diseases, beyond rheumatoid arthritis

223 citations , September 2018 in “Rheumatology”

JAK inhibitors are effective in treating various immune-related diseases, not just rheumatoid arthritis.

Upadacitinib for the Treatment of Systemic Immune Co-Morbidity in One Case: Alopecia Areata, Vitiligo, Ankylosing Spondylitis, and Allergic Rhinitis-Asthma – Multifaceted Control

research Upadacitinib for the Treatment of Systemic Immune Co-Morbidity in One Case: Alopecia Areata, Vitiligo, Ankylosing Spondylitis, and Allergic Rhinitis-Asthma – Multifaceted Control

March 2026 in “Clinical Cosmetic and Investigational Dermatology”

Upadacitinib improved multiple immune-related conditions in one patient.

research Targeting the Janus Kinase Family in Autoimmune Skin Diseases

124 citations , October 2019 in “Frontiers in Immunology”

Janus kinase inhibitors are promising treatments for autoimmune skin diseases like eczema and psoriasis.

research Hair-cycle changes in two patients taking tocilizumab

6 citations , August 2013 in “Joint Bone Spine”

Tocilizumab treatment was associated with significant hair regrowth in one patient and temporary hair loss followed by regrowth in another.

research Loose anagen hair syndrome in two patients with epidermolysis bullosa simplex, Dowling-Meara type

2 citations , August 2012 in “Journal of the American Academy of Dermatology”

Two patients with the same genetic mutation had both blistering skin and easily pulled out hair.

research Salivary Gland Inflammation During Acitretin Therapy for Generalized Pustular Psoriasis: a Case Report and Diagnostic Challenge

January 2025 in “Dermatology Review”

Acitretin may cause salivary gland inflammation.

research Index

September 2019

The document is a detailed guide on skin conditions and treatments for dermatologists.

research Table of Contents

February 2014 in “Journal of The American Academy of Dermatology”

research Upadacitinib in concurrent Crohn's disease, atopic dermatitis and alopecia areata: A case report

12 citations , July 2023 in “Journal of the European Academy of Dermatology and Venereology”

Upadacitinib improved Crohn's disease, atopic dermatitis, and alopecia areata in one patient.

research Successful treatment of severe atopic dermatitis and alopecia universalis with upadacitinib in a 29-year-old male patient

5 citations , May 2024 in “Journal of Allergy and Clinical Immunology Global”

Upadacitinib effectively improved severe atopic dermatitis and alopecia universalis in a 29-year-old man.

Successful Treatment with Upadacitinib in Concurrent Atopic Dermatitis, Crohn's Disease, Alopecia Areata, and Eosinophilic Gastropathy in a Pediatric Patient

research Successful treatment with upadacitinib in concurrent atopic dermatitis, Crohn’s disease, alopecia areata, and eosinophilic gastropathy in a pediatric patient

January 2026 in “Dermatology Reports”

Upadacitinib improved symptoms and hair regrowth in a teen with multiple autoimmune conditions.

research The emerging role of Janus kinase inhibitors in the treatment of autoimmune and inflammatory diseases

70 citations , October 2020 in “The journal of allergy and clinical immunology/Journal of allergy and clinical immunology/The journal of allergy and clinical immunology”

Janus kinase inhibitors are promising drugs for treating autoimmune and inflammatory diseases.

research Novel Janus Kinase Inhibitors in the Treatment of Dermatologic Conditions

1 citations , December 2023 in “Molecules/Molecules online/Molecules annual”

JAK inhibitors show promise for treating various skin diseases.

research Upadacitinib for the management of severe alopecia areata in adolescent patients: a single-centre retrospective study

7 citations , August 2024 in “Clinical and Experimental Dermatology”

Upadacitinib is effective and safe for treating severe alopecia areata in teens.

research Selective JAK 1 inhibition with upadacitinib as a potential treatment for coexistent severe atopic dermatitis and alopecia areata

4 citations , February 2024 in “Anais Brasileiros de Dermatologia”

research Linking diet to acne metabolomics, inflammation, and comedogenesis: an update

138 citations , July 2015 in “Clinical, Cosmetic and Investigational Dermatology”

Eating less sugar, milk, and saturated fats and more vegetables and fish may help treat and prevent acne.