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research [Proliferation behavior of the anagen hair bulb in androgenetic alopecia before and after local administration of 17 alpha- propylmesterolone–DNA flow cytophotometry studies].

December 1990 in “PubMed”

Topical 17 alpha-propylmesterolone increases hair cell growth in androgenetic alopecia.

11α-Hydroxyprogesterone, a Potent 11β-Hydroxysteroid Dehydrogenase Inhibitor, Is Metabolized by Steroid-5α-Reductase and Cytochrome P450 17α-Hydroxylase/17,20-Lyase to Produce C11α-Derivatives of 21-Deoxycortisol and 11-Hydroxyandrostenedione In Vitro

research 11α-Hydroxyprogesterone, a potent 11β-hydroxysteroid dehydrogenase inhibitor, is metabolised by steroid-5α-reductase and cytochrome P450 17α-hydroxylase/17,20-lyase to produce C11α-derivatives of 21-deoxycortisol and 11-hydroxyandrostenedione in vitro

7 citations , April 2019 in “The Journal of Steroid Biochemistry and Molecular Biology”

11α-Hydroxyprogesterone is changed into different substances by certain enzymes and may play a role in prostate cancer.

research Novel Synthetic Steroid Derivatives: Target Prediction and Biological Evaluation of Antiandrogenic Activity

December 2025 in “Current Issues in Molecular Biology”

New steroid compounds may help with hormonal therapy and have potential benefits for glucose disorders, but more research is needed.

research Scalp hair 17‐hydroxyprogesterone and androstenedione as a long‐term therapy monitoring tool in congenital adrenal hyperplasia

9 citations , April 2016 in “Clinical Endocrinology”

Scalp hair 17-OHP and androstenedione levels can help monitor treatment in CAH patients.

Synthesis of Phenanthridin-3-One Derivatives: Non-Steroidal Inhibitors of Steroid 5-Alpha-Reductase

research Synthesis of phenanthridin-3-one derivatives: Non-steroidal inhibitors of steroid 5-α-reductase

20 citations , June 1995 in “Tetrahedron Letters”

New chemicals were made that can block an enzyme linked to hair loss, prostate growth, and acne.

research Synthesis and Evaluation of 2‘-Substituted 4-(4‘-Carboxy- or 4‘-carboxymethylbenzylidene)-N-acylpiperidines: Highly Potent and in Vivo Active Steroid 5α-Reductase Type 2 Inhibitors

22 citations , June 2002 in “Journal of Medicinal Chemistry”

Compounds 15, 20, and 25 are strong inhibitors of human steroid 5α-reductase type 2.

research A Convenient Synthesis of (16S,20S)-3β-Hydroxy-5α-pregnane-20,16-carbolactam and Its N-alkyl Derivatives

2 citations , May 2020 in “Molecules”

A new, efficient method was developed to synthesize a specific compound and its derivatives.

research 4 Anti-androgens in gynaecological practice

7 citations , September 1988 in “Baillière's clinical obstetrics and gynaecology”

Cyproterone acetate is effective for treating hirsutism and acne in women by blocking androgens in the skin and also works as a contraceptive.

research Nanostructured Lipid Carriers Loaded with 17-α-Estradiol Accumulate into Hair Follicles

January 2021 in “Figshare”

Tiny lipid particles carrying 17-α-estradiol gather in hair follicles, which may help target alopecia treatment.

research Clascoterone: a new topical antiandrogen agent.

February 2025 in “Prospects in Pharmaceutical Sciences”

Clascoterone is a promising topical treatment for hair loss and acne with fewer side effects.

Biological Activity of Novel Progesterone Derivatives Having Bulky Ester Side Chains at C-3

research Biological activity of novel progesterone derivatives having a bulky ester side chains at C-3

15 citations , April 2008 in “Steroids”

The more lipophilic the progesterone derivative, the better it binds to androgen receptors and has antiandrogenic effects.

research N-Acyl arylsulfonamides as novel, reversible inhibitors of human steroid sulfatase

17 citations , December 2004 in “Bioorganic & Medicinal Chemistry Letters”

Scientists found new, better-working inhibitors for a hormone-related enzyme.

research Hormonal therapies for acne

26 citations , October 2016 in “Clinics in Dermatology”

Hormonal treatments can improve acne, but they come with potential side effects and risks.

research Synthesis of a 4-azasteroid hormones compound

January 2009 in “Xiandai huagong”

Finasteride was successfully synthesized from Pregnadienolone acetate.

research ANDROGEN AND CORTISOL SECRETING ADRENOCORTICAL ONCOCYTOMA WITTH UNCERTAIN MALIGNANT POTENTIAL

July 2019 in “Journal of the ASEAN Federation of Endocrine Societies”

The woman had a rare adrenal tumor removed, and she recovered well with no signs of the tumor returning.

research 2-Substituted 4-(Thio)chromenone 6-O-Sulfamates: Potent Inhibitors of Human Steroid Sulfatase

111 citations , August 2002 in “Journal of Medicinal Chemistry”

New compounds were made that block an enzyme linked to breast cancer better than existing treatments.

research Non-classical Congenital Adrenal Hyperplasia Presenting With Severe Androgenic Alopecia: A Case Report

February 2025 in “Cureus”

Early diagnosis and treatment of NCCAH can improve symptoms and fertility.

research New Nonsteroidal Molecules as Blockers of the Steroidogenic Pathway

January 2022 in “Current Enzyme Inhibition”

New nonsteroidal molecules can potentially increase dihydrotestosterone in neurons by blocking certain enzymes, without affecting prostate and seminal vesicle weight.

research BindingDB Entry 50021519: Discovery of (2S)-N-(6-Cyano-5-(trifluoromethyl)pyridin-3-yl)-3-(6-(4-cyanophenyl)-3,6-diazabicyclo[3.1.1]heptan-3-yl)-2-hydroxy-2-methylpropanamide as a Highly Potent and Selective Topical Androgen Receptor Antagonist for Androgenetic Alopecia Treatment.

January 2025

research Activity of steroid 4 and derivatives 4a–4f as inhibitors of the enzyme 5α-reductase 1

3 citations , June 2018 in “Bioorganic & medicinal chemistry”

Compounds 4, 4b, and 4c effectively inhibit an enzyme linked to testosterone conversion without significant toxicity.

research [Antiandrogen therapy of acne, falling hair and hirsutism (author's transl)].

June 1980 in “PubMed”

Cyproterone acetate is an effective treatment for women with acne, hair loss, and excessive hair growth.

Evaluation of New Pregnane Derivatives as 5α-Reductase Inhibitors

research Evaluation of New Pregnane Derivatives as 5.ALPHA.-Reductase Inhibitor.

23 citations , January 2001 in “Chemical & Pharmaceutical Bulletin”

New pregnane derivatives are effective at inhibiting an enzyme linked to hair loss and reducing oil gland activity.

research 3,3-Diphenylpentane skeleton as a steroid skeleton substitute: Novel inhibitors of human 5α-reductase 1

13 citations , August 2007 in “Bioorganic & medicinal chemistry letters”

A new compound effectively inhibits human 5α-reductase 1.

Compatibility of 17-Alpha-Estradiol, Caffeine, Clobetasol Propionate, Finasteride, Melatonin, Metronidazole, Spironolactone, Tretinoin, and Triamcinolone in Trichosol, a Natural Vehicle for Hair Solutions

research Compatibility of 17-a-estradiol, Caffeine, Clobetasol Propionate, Finasteride Melatonin, Metronidazole, Spironolactone, Tretinoin, and Triamcinolone in Trichosol, a Natural Vehicle for Hair Solutions.

May 2025 in “PubMed”

TrichoSol™ effectively stabilizes various hair treatment ingredients for different durations.

Compatibility of Caffeine, Clobetasol Propionate, Dutasteride, Nicotinamide, and Progesterone in TrichoFoam, a Natural Vehicle for Hair Foams

research Compatibility of Caffeine Clobetasol Propionate Dutasteride Nicotinamide and Progesterone in TrichoFoam™, a Natural Vehicle for Hair Foams.

April 2024 in “PubMed”

TrichoFoam™ is a stable option for personalized hair loss treatment with most ingredients remaining effective for 90-180 days.

research The influence of selected steroid hormones on the physicochemical behaviour of DPPC liposomes

65 citations , April 2007 in “Chemistry and Physics of Lipids”

Steroid hormones change the size, charge, and stability of DPPC liposomes.

research Anti-acne drugs in phase 1 and 2 clinical trials

27 citations , June 2017 in “Expert opinion on investigational drugs”

New anti-acne medications are being tested to offer alternatives to current treatments.

research Steroid 5α-Reductase Inhibitors

42 citations , May 2003 in “Mini-reviews in Medicinal Chemistry”

New steroidal compounds could be effective for treating conditions related to 5α-reductase enzyme activity.

research Androgens and acne: perspectives on clascoterone, the first topical androgen receptor antagonist

9 citations , April 2021 in “Expert opinion on pharmacotherapy”

Clascoterone is a new, effective, and safe acne treatment without systemic side effects.

Comparative Evaluation of the Efficacy of Topical Tacrolimus 0.03% and Topical Calcipotriol 0.005% Mixed With Betamethasone Dipropionate Versus Topical Clobetasol 0.05% in Treatment of Alopecia Areata: A Clinical and Trichoscopic Study

research Comparative evaluation of the efficacy of topical tacrolimus 0.03% and topical calcipotriol 0.005% mixed with betamethasone dipropionate versus topical clobetasol 0.05% in treatment of alopecia areata: A clinical and trichoscopic study

1 citations , December 2022 in “Journal of cosmetic dermatology”

The combination of vitamin D analogues with potent steroids is a favorable treatment for alopecia areata with fewer side effects.

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