October 2022 in “Biomedicines” Finasteride in male rats causes liver and metabolic issues in their offspring.
2 citations
,
February 2024 in “bioRxiv (Cold Spring Harbor Laboratory)” Androgens like testosterone make Staphylococcus aureus skin infections more common in men.
December 2022 in “Small methods” A new hair loss treatment using dissolving microneedles was found to speed up hair growth and was more effective than daily use of common hair growth drugs.
100 citations
,
September 2017 in “Molecular and Cellular Endocrinology” Male hormones and their receptors play a key role in hair loss and skin health, with potential new treatments being explored.
38 citations
,
July 2012 in “international journal of endocrinology and metabolism” Some plant-derived compounds may help with hormonal conditions, but more research is needed to confirm their effectiveness.
July 2015 in “Cambridge University Press eBooks” Androgens like testosterone affect skin health and can lead to conditions such as acne and hair loss, with various treatments available.
56 citations
,
July 2014 in “PloS one” SARMs may be an effective treatment for a certain type of breast cancer by blocking cancer growth and spread.
50 citations
,
July 2014 in “International Journal of Clinical Pharmacology and Therapeutics” New finasteride solution effectively reduces baldness-causing hormone, potentially with fewer side effects.
19 citations
,
April 2018 in “Clinical cardiology” Older men with low levels of a testosterone byproduct had a higher chance of developing an irregular heartbeat.
11 citations
,
May 2009 in “Medical Hypotheses” Male pattern baldness is an unintended side effect of the body's use of androgens for muscle growth, especially in those genetically prone to it.
6 citations
,
August 2013 in “Fertility and Sterility” Eating cream can increase ovarian androgen production in women with Polycystic Ovary Syndrome, which is not related to obesity.
3 citations
,
October 2019 in “Dermatologic Therapy” Hair loss in men is mainly caused by hormones and genes, and while current treatments can slow it down, they can't fully stop it.
May 2026 in “Zenodo (CERN European Organization for Nuclear Research)” Alopecia is a complex disorder influenced by hormonal, genetic, immunological, and environmental factors, leading to disrupted hair follicle cycling. The review discusses the molecular mechanisms involved, such as androgen-mediated follicular miniaturization and immune dysregulation, and highlights the roles of epigenetic changes and microbiome imbalances. Current treatments mainly offer symptomatic relief with limited long-term efficacy. However, advancements in regenerative medicine, targeted therapies, and innovative drug delivery systems show promise in addressing underlying mechanisms. The review emphasizes the potential of natural compounds and polyherbal formulations and advocates for multi-dimensional, mechanism-based approaches for more effective alopecia management.
May 2026 in “Zenodo (CERN European Organization for Nuclear Research)” Alopecia is a complex disorder influenced by hormonal, genetic, immunological, and environmental factors, leading to disrupted hair follicle cycling. The review discusses the molecular mechanisms involved, such as androgen-mediated follicular miniaturization and immune dysregulation, and highlights the roles of epigenetic changes and microbiome imbalances. Current treatments mainly offer symptomatic relief with limited long-term efficacy. However, advancements in regenerative medicine, targeted therapies, and innovative drug delivery systems show promise in addressing underlying mechanisms. The review emphasizes the potential of natural compounds and polyherbal formulations and advocates for multi-dimensional, mechanism-based approaches for more effective alopecia management.
November 2025 in “Journal of Investigative Dermatology” Minoxidil helps hair growth by improving blood vessel function.
33 citations
,
December 2017 in “Journal of neuroendocrinology” Sex and stress steroids quickly change brain cell structures in the hippocampus.
4 citations
,
July 2020 in “Research Square (Research Square)” The research helps understand how finasteride works and aids drug development.
May 2013 in “Journal of the Egyptian Women's Dermatologic Society (Print)” High aldosterone and free testosterone levels link to female hair loss; testing aldosterone may predict hypertension risk.
138 citations
,
April 2003 in “Carcinogenesis” 2-Methoxyestradiol causes cancer cell death by activating specific pathways, but androgens can block this effect.
Hair loss is caused by hormonal changes that shorten hair growth phases and shrink hair follicles.
January 2013 in “Российский журнал кожных и венерических болезней” Androgenic alopecia, a common hair loss condition, is linked to changes in androgen metabolism and genetics, and can be treated with finasteride and minoxidil, but these treatments are only fully effective in 10% of patients.
54 citations
,
September 2012 in “Dermatologic Clinics” Some medications can cause hair loss, but stopping the drug usually leads to recovery within 3 months.
November 2008 in “Medical Hypotheses” The conclusion suggests a new treatment for infantile hemangiomas and a potential target for hair loss treatment.
58 citations
,
October 2001 in “Dermatologic Clinics” Hair loss can indicate underlying systemic diseases and addressing these can sometimes reverse the hair loss.
45 citations
,
June 2003 in “Journal of Investigative Dermatology Symposium Proceedings” Understanding hair follicles through various models can help develop new treatments for hair disorders.
6 citations
,
October 2007 in “Medical Hypotheses” Male pattern baldness might have evolved to help protect against prostate cancer by increasing UV radiation on the scalp.
April 2025 in “European Journal of Pharmaceutics and Biopharmaceutics” The new drug delivery system improves bicalutamide skin retention for better treatment of hair loss.
February 2025 in “Prospects in Pharmaceutical Sciences” Clascoterone is a promising topical treatment for hair loss and acne with fewer side effects.
January 2024 in “Wiadomości Lekarskie” The ABI1 gene contributes to prostate cancer progression and treatment resistance.
July 2014 in “International Journal of Dermatology and Venereology” Cytokines play a key role in hair loss by affecting hair growth.