research Genetic analysis of the role of androgen metabolism in the pathogenesis of prostate cancer
Certain genetic markers can indicate a person's risk of developing prostate cancer.
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research Alopecia androgénica femenina: nuevos factores fisiopatológicos y futuras tendencias para un abordaje clínico más integral
New factors in female hair loss include genetics, hormones, stress, and inflammation; future treatments should also focus on these areas and consider the patient's emotional well-being.
research Polymorphism of the Androgen Receptor Gene is Associated with Male Pattern Baldness
Male pattern baldness is linked to specific genetic variations in the androgen receptor gene.
research A genome-wide association scan in admixed Latin Americans identifies loci influencing facial and scalp hair features
Genetic factors influence hair traits like shape, color, and greying in Latin Americans.
research Molecular epidemiology of hypospadias: Review of genetic and environmental risk factors
Both genes and environmental factors like chemicals may contribute to the increase in hypospadias, but the exact causes are still unclear.
research Membrane androgen receptors may mediate androgen reinforcement
Androgen self-administration might be controlled by membrane receptors, not nuclear ones.
research Inhibition of Hair Growth by Testosterone in the Presence of Dermal Papilla Cells from the Frontal Bald Scalp of the Postpubertal Stumptailed Macaque1
Testosterone can slow down hair growth when combined with certain cells from bald scalps, and this effect can be blocked by an androgen receptor blocker.
research Relations between sex hormone level and characters of hair and skin in healthy young men
Higher androgen levels do not cause baldness in men.
research Hyperandrogénie féminine
The document concludes that managing female hyperandrogenism requires a combination of identifying the cause, lifestyle changes, medication, and cosmetic treatments.
research Alternative synthesis of the anti-baldness compound RU58841
A new, less toxic and more efficient method to create the anti-baldness compound RU58841 was developed in 2014.
research Is the “Comb Over” Dying? A Mouse Model for Male Pattern Baldness (Androgenic Alopecia)
The mouse model suggests male pattern baldness may be due to an enzyme increasing DHT and higher androgen receptor levels in hair follicles.
research Structural perspectives on the androgen receptor, the elusive shape-shifter
The androgen receptor's shape-changing ability helps it function but can lead to cancer treatment resistance.
research Polymorphisms in Genes Involved in Steroidogenesis in the Development of Severe Acne
Certain gene variations are linked to a higher risk of severe acne, suggesting a genetic influence on the condition.
research Hormone Blocking Anticancer Drugs
The document explains how certain drugs block hormones to treat cancers like breast and prostate cancer.
research Diffuser Haarausfall und klinische Endokrinologie: Neue Erkenntnisse
Hormones significantly affect hair growth and loss, with potential for new treatments.
research Androgen Regulation of the Human Hair Follicle: The Type I Hair Keratin hHa7 Is a Direct Target Gene in Trichocytes
The hHa7 gene is regulated by androgens in certain body hair, not scalp hair.
research Synaptic Long-Term Potentiation and Depression in the Rat Medial Vestibular Nuclei Depend on Neural Activation of Estrogenic and Androgenic Signals
Estrogen and androgen signals control synaptic changes in rat brains.
research Synthesis of 11α-hydroxyprogesterone hartens
Researchers successfully made new compounds for hormone level tests, but one attempt led to an unexpected product, correcting a past error.
research Inhibition of Hair Growth by Testosterone in the Presence of Dermal Papilla Cells from the Frontal Bald Scalp of the Postpubertal Stumptailed Macaque
Testosterone can slow hair growth in adult monkeys, but a blocker called RU 58841 can counteract this and potentially help hair regrow.
research Wanted, dead and alive: Why a multidisciplinary approach is needed to unlock hair treatment potential
Different fields of expertise must work together to better understand hair growth and create effective hair loss treatments.
research Age-related differences in the reproductive and metabolic implications of polycystic ovarian syndrome: findings in an obese, United States population
Older obese women with PCOS have higher cardiovascular and metabolic risks despite lower androgen levels.
research Breaking the ‘rule-of-five’ to access bridged bicyclic heteroaromatic bioisosteres
A new method creates unique chemical structures that could improve drug discovery.
research Androgenetic alopecia in adolescents: A report of 43 cases
Teen hair loss common in boys, linked to family history and mild symptoms.
research Synthesis and Pharmacological Evaluation of New 16-Methyl Pregnane Derivatives.
New pregnane derivatives were more effective than finasteride at inhibiting a key enzyme for male pattern baldness.
research The hairless gene in androgenetic alopecia: results of a systematic mutation screening and a family-based association approach
Hairless gene not strongly linked to baldness.
research Genetic analysis of 5 α reductase type 2 enzyme in relation to oxidative stress in cases of androgenetic alopecia in a sample of egyptian population
5α reductase type 2 enzyme mutation and oxidative stress may increase androgenetic alopecia risk in Egyptians.
research TYPICAL MORPHOLOGICAL CHARACTERISTICS OF THE SKIN STRUCTURE OF THE HAIR PART OF THE NORMAL HUMAN HEAD AND WITH HAIR LOSS
Androgenic alopecia causes hair follicle degradation and skin restructuring, but some hair elements remain.
research Androgenic Alopecia and Stress-Induced Premature Senescence by Cumulative Ultraviolet Light Exposure
Chronic exposure to sunlight may worsen male pattern baldness and protecting the scalp from the sun could slow it down.
research Inhibition of rat α-reductases by finasteride: Evidence for isozyme differences in the mechanism of inhibition
Finasteride effectively blocks rat enzymes, but with varying methods and strength.
research Nonsteroidal inhibitors of human type I steroid 5-.alpha.-reductase
New compounds called benzoquinolinones may treat conditions linked to excess DHT.