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GlossaryAndrogen Pathway

process by which androgens influence cellular functions and characteristics

The androgen pathway involves the process by which androgens, a group of hormones like testosterone, interact with cells in the body. These hormones bind to androgen receptors, influencing various biological functions such as hair growth, muscle development, and the regulation of male characteristics. In the context of hair, this pathway can affect hair follicle health and is often linked to conditions like androgenetic alopecia (pattern baldness).

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An Analysis of Gene Expression Data Involving Examination of Signaling Pathways Activation Reveals New Insights into the Mechanism of Action of Minoxidil Topical Foam in Men with Androgenetic Alopecia

research An analysis of gene expression data involving examination of signaling pathways activation reveals new insights into the mechanism of action of minoxidil topical foam in men with androgenetic alopecia

12 citations , June 2017 in “Cell Cycle”

Minoxidil foam helps hair growth by increasing good proteins and decreasing bad pathways in men with hair loss.

research The AR/miR-221/IGF-1 pathway mediates the pathogenesis of androgenetic alopecia

2 citations , January 2023 in “International Journal of Biological Sciences”

A specific pathway involving AR, miR-221, and IGF-1 plays a key role in causing common hair loss.

research Molecular Mechanisms and Targeted Therapeutics in Androgenetic Alopecia: From Signaling Pathways to Regenerative Approaches

May 2026 in “Premier journal of science.”

Future treatments for hair loss may focus on personalized and regenerative approaches.

Microenvironmental Dysregulation in Androgenetic Alopecia: Molecular Pathways and Translational Implications for Regenerative Therapies

research Microenvironmental Dysregulation in Androgenetic Alopecia: Molecular Pathways and Translational Implications for Regenerative Therapies

March 2026 in “Zenodo (CERN European Organization for Nuclear Research)”

Regenerative therapies could help treat hair loss in androgenetic alopecia.

research Microenvironmental Dysregulation in Androgenetic Alopecia: Molecular Pathways and Translational Implications for Regenerative Therapies

March 2026 in “Zenodo (CERN European Organization for Nuclear Research)”

Regenerative therapies may help treat hair loss in androgenetic alopecia.

research Microenvironmental Dysregulation in Androgenetic Alopecia: Molecular Pathways and Translational Implications for Regenerative Therapies

March 2026 in “Zenodo (CERN European Organization for Nuclear Research)”

Regenerative therapies could help treat hair loss in androgenetic alopecia.

research i-PRF-Derived Exosomes Promote Hair Regeneration by Modulating Inflammatory, Oxidative, Angiogenic, and Regenerative Pathways in an Androgenetic Alopecia Mouse Model

February 2026 in “Trends in Sciences”

i-PRF-derived exosomes can effectively promote hair growth and improve hair health in androgenetic alopecia.

research Effects of Camellia oleifera seed shell polyphenols and 1,3,6-tri-O-galloylglucose on androgenic alopecia via inhibiting 5a-reductase and regulating Wnt/β-catenin pathway

July 2024 in “Fitoterapia”

Camellia oleifera seed shell polyphenols and 1,3,6-tri-O-galloylglucose can help treat hair loss by reducing certain hormones and promoting hair growth.

research Network Pharmacology Reveals Curcuma aeruginosa Roxb. Regulates MAPK and HIF-1 Pathways to Treat Androgenetic Alopecia

July 2024 in “Biology”

Curcuma aeruginosa Roxb. may help treat hair loss by affecting specific biological pathways.

research THE ROLE OF AGONISTS AND ANTAGONISTS OF THE WNT SIGNALING PATHWAY IN PATIENTS WITH ANDROGENIC ALOPECIA AND ALOPECIA AREATA

February 2021 in “Медико-фармацевтический журнал "Пульс"”

Understanding WNT signaling proteins can help predict and treat certain types of hair loss.

research 896 Androgens activate lipogenesis through an AKT-independent mTOR pathway stimulation and a limitation of autophagy in an androgen-sensitive sebocyte cell line

April 2019 in “Journal of Investigative Dermatology”

Dihydrotestosterone (DHT) increases oil production in skin cells by activating mTOR, and mTOR inhibitors can reduce this effect.

research Cross-kingdom delivery and putative gene modulation of androgen pathways by plant-derived exosome-like nanoparticles from polygoni multiflori radix promotes hair growth via miRNA cargo

November 2025 in “Pharmacological Research”

Plant-derived nanoparticles from Polygoni Multiflori Radix promote hair growth better than Minoxidil by affecting androgen pathways.

research 712 A small molecule modulator of the wnt pathway (SM04554) as a potential topical treatment for androgenetic alopecia (AGA)

1 citations , April 2017 in “Journal of Investigative Dermatology”

SM04554 may increase hair growth as a topical treatment for androgenetic alopecia.

research Terminalia bellirica (Gaertn.) Roxb. extracts reshape the perifollicular microenvironment and regulate the MAPK pathway for androgenetic alopecia treatment

September 2024 in “Journal of Ethnopharmacology”

Terminalia bellirica extracts effectively promote hair regrowth and treat androgenetic alopecia.

Pilose Antler Extracts Promote Hair Growth in Androgenetic Alopecia Mice by Activating Hair Follicle Stem Cells via the AKT and Wnt Pathways

research Pilose antler extracts promotes hair growth in androgenetic alopecia mice by activating hair follicle stem cells via the AKT and Wnt pathways

July 2024 in “Frontiers in Pharmacology”

Pilose antler extracts help hair growth by activating hair follicle stem cells.

research Regulatory pathways implicated in male androgenetic alopecia pathogenesis

November 2017 in “British Journal of Dermatology”

Genes controlling hair growth and immune response are disrupted in male pattern baldness.

research Ar/miR-221/IGF-1 Pathway Mediates the Pathogenesis of Androgenetic Alopecia

January 2022 in “Social Science Research Network”

The Ar/miR-221/IGF-1 pathway is involved in male pattern baldness, with miR-221 potentially being a new target for treatment.

Vascular Endothelial Growth Factor Protects CD200-Rich and CD34-Positive Hair Follicle Stem Cells Against Androgen-Induced Apoptosis Through the Phosphoinositide 3-Kinase/Akt Pathway in Patients With Androgenic Alopecia

research Vascular Endothelial Growth Factor Protects CD200-Rich and CD34-Positive Hair Follicle Stem Cells Against Androgen-Induced Apoptosis Through the Phosphoinositide 3-Kinase/Akt Pathway in Patients With Androgenic Alopecia

11 citations , September 2019 in “Dermatologic Surgery”

A substance called Vascular Endothelial Growth Factor can protect certain hair follicle stem cells from damage caused by androgens, suggesting a new possible treatment for hair loss.

research Caizhixuan hair tonic regulates both apoptosis and the PI3K/Akt pathway to treat androgenetic alopecia

February 2023 in “PLOS ONE”

Caizhixuan hair tonic helps treat hair loss by promoting hair growth and improving hair follicles.

Fructus Psoraleae Treating Androgenetic Alopecia Through 5-Alpha Reductase Inhibition and Nrf2-Keap1 Pathway

research Fructus Psoraleae Treating in Androgenetic Alopecia Through 5-Α Reductase Inhibition and Nrf2-Keap1 Pathway

January 2024

Fructus Psoraleae may help treat hair loss by inhibiting 5-α reductase and affecting the Nrf2-Keap1 pathway.

Cross-Interactions of BMP and WNT Signaling Pathways Attenuate Androgen Effect on Hair Follicle Stem Cell Differentiation

research 592 Cross-interactions of BMP and WNT signaling pathways attenuate androgen effect on HFSC differentiation

September 2019 in “Journal of Investigative Dermatology”

BMPs are important for hair growth and can counteract the negative effects of androgens on hair follicle stem cells.

Randomized Trial of Electrodynamic Microneedling Combined with 5% Minoxidil Topical Solution for Treating Androgenetic Alopecia in Chinese Males and Molecular Mechanistic Study of the Involvement of the Wnt/β-Catenin Signaling Pathway

research Randomized trial of electrodynamic microneedling combined with 5% minoxidil topical solution for treating androgenetic alopecia in Chinese males and molecular mechanistic study of the involvement of the Wnt/β-catenin signaling pathway

10 citations , May 2020 in “Journal of Dermatological Treatment”

Microneedling with 5% minoxidil improves hair loss in Chinese men by activating Wnt/ß-catenin pathway.

research Identification of immune microenvironment changes, immune-related pathways and genes in male androgenetic alopecia

September 2023 in “Medicine”

The research suggests immune system changes and specific gene expression may contribute to male hair loss, proposing potential new treatments.

Ginsenoside CK Inhibits Androgenetic Alopecia by Regulating Wnt/Beta-Catenin and P53 Signaling Pathways in AGA Mice

research Ginsenoside CK inhibits androgenetic alopecia by regulating Wnt/β‐catenin and p53 signaling pathways in AGA mice

June 2023 in “Food frontiers”

Ginsenoside CK, found in Panax ginseng, can prevent hair loss by controlling certain growth pathways and promoting hair follicle development.

research Wnt/β-Catenin Signaling Pathway Targeting Androgenetic Alopecia: How Far Can We Go Beyond Minoxidil and Finasteride?

September 2025 in “Journal of Medicinal Chemistry”

Targeting the Wnt/β-catenin pathway may lead to better treatments for hair loss.

Study of Gene Expression Alteration in Male Androgenetic Alopecia: Evidence of Predominant Molecular Signaling Pathways

research Study of gene expression alteration in male androgenetic alopecia: evidence of predominant molecular signalling pathways

27 citations , April 2017 in “British Journal of Dermatology”

Hair loss involves immune responses, inflammation, and disrupted signaling pathways.

Androgenetic Alopecia: Combing the Hair Follicle Signaling Pathways for New Therapeutic Targets and More Effective Treatment Options

research Androgenetic alopecia: combing the hair follicle signaling pathways for new therapeutic targets and more effective treatment options

19 citations , August 2019 in “Expert Opinion on Therapeutic Targets”

New treatments for hair loss may target specific pathways and generate new hair follicles.

Comprehensive Analysis of LncRNA AC010789.1 Delays Androgenic Alopecia Progression by Targeting MicroRNA-21 and the Wnt/β-Catenin Signaling Pathway in Hair Follicle Stem Cells

research Comprehensive Analysis of LncRNA AC010789.1 Delays Androgenic Alopecia Progression by Targeting MicroRNA-21 and the Wnt/β-Catenin Signaling Pathway in Hair Follicle Stem Cells

3 citations , February 2022 in “Frontiers in Genetics”

The LncRNA AC010789.1 slows down hair loss by promoting hair follicle growth and interacting with miR-21 and the Wnt/β-catenin pathway.

research Insights into male androgenetic alopecia using comparative transcriptome profiling: hypoxia-inducible factor-1 and Wnt/β-catenin signalling pathways

1 citations , July 2022 in “British Journal of Dermatology”

Targeting specific genes in certain pathways may help treat male pattern baldness.

Therapeutic Potential of Ishophloroglucin A from Ishige Okamurae in Androgenic Alopecia: Inhibition of 5α-Reductase Activity and Activation of the Wnt/β-Catenin Signaling Pathway in Human Dermal Papilla Cells

research Therapeutic potential of Ishophloroglucin a from Ishige okamurae in androgenic alopecia: inhibition of 5α-reductase activity and activation of the Wnt/β-catenin signaling pathway in human dermal papilla cells

January 2026 in “Applied Biological Chemistry”

Ishophloroglucin A from Ishige okamurae may be a natural alternative for treating hair loss by inhibiting 5α-reductase and promoting hair growth.