31 citations
,
January 1989 in “The Prostate/The prostate” Estradiol and castration reduced prostate cancer development in rats when applied at early stages, but were ineffective after cancer was established.
26 citations
,
November 2006 in “Pharmacology, Biochemistry and Behavior” Pregnancy reduces anxiety in rats, but finasteride reverses this effect.
August 2012 in “Open Repository and Bibliography (University of Liège)” A castrated dog developed hair loss and prostate issues from long-term exposure to estrogen cream.
89 citations
,
August 2013 in “PloS one” Androgen receptors are active in many tissues of both male and female mice, not just reproductive organs.
January 2013 in “Reproductive Biology” October 2025 in “Journal of the Endocrine Society” Anastrozole can cause increased testosterone, leading to symptoms like hair growth and thinning.
Finasteride significantly reduced sperm production and caused testicular atrophy in hamsters.
32 citations
,
September 2010 in “Stress” Neurosteroids help protect fetal brains from asphyxia damage.
Male goat smell increases reaction in young female goats' noses but doesn't cause them to start puberty early.
62 citations
,
August 2018 in “Frontiers in Endocrinology” Androgens are important for normal ovarian function and estrogen production, but may not be the main cause of follicle death.
12 citations
,
February 2017 in “Journal of neuroscience research” Removing certain brain receptors in mice worsens seizure severity and response to treatment during hormone withdrawal.
September 2008 in “Fertility and Sterility” Exposure to fatty acids significantly increased androgen levels in female dogs, suggesting a link to conditions like insulin resistance and PCOS.
4 citations
,
January 2006 in “PubMed” DHT deficiency may disrupt rat epididymis function by affecting estrogen receptors.
9 citations
,
August 2021 in “Biomedicines” 17β-estradiol boosts APE1/Ref-1 secretion in cells and mice via a calcium-dependent pathway.
5 citations
,
March 2005 in “Journal of The American Academy of Dermatology”
11 citations
,
November 2006 in “Journal of Veterinary Diagnostic Investigation” An alpaca acted like a male and couldn't have babies because of a benign tumor in its ovary that caused high testosterone levels.
3 citations
,
April 1977 in “PubMed” The treatment improved acne, seborrhoea, and hirsutism, with some side effects like spotting and nervousness.
December 2015 in “OPAL (Open@LaTrobe) (La Trobe University)” Estrogen speeds up hair follicle cell death, causing early hair growth cycle changes, but only if a specific receptor is present.
1 citations
,
February 2015 in “Revista Acadêmica Ciência Animal” A mare had a functional ovary with a tumor containing cartilage and bone.
Ovulation inhibitors effectively treat menstrual issues and improve fertility but can have side effects.
7 citations
,
October 2017 in “Journal of exotic pet medicine” A guinea pig with ovarian cysts had a uterine infection and abnormal uterus lining due to a piece of hay inside it.
3 citations
,
February 1992 in “Journal of veterinary medicine. Series A” The farm-raised blue fox had a delayed winter coat cycle and abnormal hormone levels, but its hair growth and hormone changes were still linked.
1 citations
,
September 2024 in “Journal of Clinical & Translational Endocrinology” PCOS women have more severe metabolic issues and higher androgen levels than hyperandrogenic women without PCOS.
11 citations
,
July 1998 in “Journal of Investigative Dermatology” β-estradiol slows hair growth in mice.
5 citations
,
December 2018 in “Frontiers in Endocrinology” Differences in androgen receptor expression and tissue properties may lead to higher cryptorchidism risk in certain rats.
6 citations
,
April 2004 in “Journal of Enzyme Inhibition and Medicinal Chemistry” New progesterone-based compounds can block male hormones.
A spayed dog with vaginal bone structures causing infection was successfully treated by removing the bones and administering medication.
25 citations
,
March 2004 in “Regulatory Toxicology and Pharmacology” Using testosterone-stimulated weanling rats can effectively replace castrated rats for anti-androgen testing, reducing animal stress.
21 citations
,
December 2019 in “PloS one” The rat model showed early perimenopause with regular cycles and low hormones, and late perimenopause with irregular cycles and higher hormone levels.
October 2025 in “Journal of Obstetric and Gynaecological Practices POGS”