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Mutations at Val-889 and Arg-752 disrupt key interactions in the androgen receptor, affecting its function.

Reduced plakoglobin and steroid abuse increase the risk of heart rhythm issues.

Hormonal contraceptives may reduce social behavior and sexual motivation by lowering allopregnanolone levels.

Blocking testosterone speeds up wound healing in males.

The treatment reduced hair growth and testosterone in women with excess hair and had some effects on stress responses.

Progesterone reduces spinal reflex activity by increasing certain GABA(A) receptor subtypes.

Scientists made all eight versions of a compound called cyoctol, but found it's not an anti-androgen and it fully breaks down in the skin.

A patient with zinc depletion improved after zinc supplementation during parenteral nutrition.

Managing oxidative stress might help treat low testosterone and related chronic diseases in aging men.

Adrenalectomy boosts hair growth and melanin in black rats, even with vitamin B¹ deficiency.

PROTACs show promise for cancer treatment, but designing them effectively is challenging.

Understanding how different body systems interact can improve how we prevent or treat frailty in aging.

Certain hormones can reduce skin oil and hair growth, potentially helping treat acne and excessive hair in women.

Block and replace therapy improved symptoms in recurrent cyclic Cushing’s disease.

Enhancing antioxidant responses can improve treatments for various diseases.

Adrenocortical extract is less effective at stopping hair growth in young rats than in adult rats.

Altered metabolism can help control seizures by changing brain signaling and energy use, suggesting new treatments for epilepsy.

Not eating enough protein can cause hair roots to shrink and lose color, and hair to become thinner.

Cathepsin L deficiency causes large, abnormal cell structures and health issues in mice.

Newly designed proteins can effectively degrade specific proteins in cells, offering a promising alternative for targeted protein degradation.

AC-5216 reduces anxiety in mice through neurosteroids affecting GABAA receptors.

TGFβ1 expression in skin causes hair loss and skin thickening, but these effects are reversible.

Blocking 5α-reductase can harm memory and brain structure, and increase harmful brain changes in male mice used for Alzheimer's disease research.

Reactive lipids from aging cells change the extracellular matrix, affecting cell function and inflammation.

New methods to make oxasteroids show promise for medical treatments like osteoporosis and breast cancer.

Adults with classic congenital adrenal hyperplasia value medication that prevents weight gain from glucocorticoids the most.

Mutants of CYP154C2 enzyme significantly improved steroid conversion efficiency.

Pregnancy and nursing increase certain brain activities in rats, but these changes disappear when the babies are taken away.

Adipose tissue-derived therapies show promise for improving osteoarthritis symptoms but need more research for safety and effectiveness.

Early sunburn treatment with certain inhibitors may reduce skin cancer risk.